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Active Recombinant Human KHK, His-tagged

Cat.No. : KHK-450H
Product Overview : Recombinant Human KHK (Met1-Val298), fused with C-terminal 6-His tag, was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.
Source : E. coli
Species : Human
Tag : His
Predicted N Terminal : Met1
Form : Supplied as a 0.2 µm filtered solution in Tris, NaCl, Brij-35 and DTT.
Bio-activity : Measured by its ability to phosphorylate D-(-)-fructose. The specific activity is >1,100 pmol/min/µg.
Molecular Mass : Predicted Molecular Mass: 34 kDa SDS-PAGE: 28-32 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.
Storage : Avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
Gene Name : KHK ketohexokinase (fructokinase) [ Homo sapiens (human) ]
Official Symbol : KHK
Synonyms : KHK; ketohexokinase (fructokinase); ketohexokinase; hepatic fructokinase; NP_000212.1; EC 2.7.1.3; NP_006479.1
Gene ID : 3795
mRNA Refseq : NM_000221
Protein Refseq : NP_000212
MIM : 614058
UniProt ID : P50053
Chromosome Location : 2p23.3
Pathway : Fructose and mannose metabolism; Fructose catabolism; sucrose degradation V (mammalian)
Function : ATP binding; ketohexokinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How is the activity of KHK protein regulated? 10/15/2022

Activity of KHK protein is affected by many factors, including gene expression, hormone levels, nutritional status, etc. In addition, some small molecule compounds can also regulate the activity of KHK proteins.

What is the relationship between KHK protein and the occurrence and progression of disease? 05/02/2022

Some studies have shown that abnormal expression of the KHK protein may be related to the occurrence and progression of some diseases. For example, in some cancers, the expression level of the KHK protein may change. In addition, the KHK protein may also be a drug target for the treatment of these diseases.

How to use the activity of KHK protein for disease treatment? 07/06/2021

The activity of the KHK protein can be modulated by drugs or other small molecule compounds to treat diseases related to the KHK protein. For example, some drugs can inhibit the activity of the KHK protein to treat diseases associated with abnormal metabolism of ketone bodies

What diseases are mutations or abnormal expression of the KHK protein associated with? 03/11/2021

Some studies have shown that mutations or abnormal expression of the KHK protein may be related to some diseases, such as cancer, neurodegenerative diseases, etc. However, the specific association needs to be confirmed by further research.

How about the interaction between the KHK protein and other enzymes or proteins? 02/14/2021

The interaction between the KHK protein and other enzymes or proteins is complex. For example, it may interact with fatty acid synthase to co-catalyze the synthesis of ketone bodies. In addition, it may interact with some regulators to regulate its activity.

How to use KHK protein for disease diagnosis? 12/15/2019

The occurrence, progression, and prognosis of the disease can be assessed by examining the expression level, activity, and interaction of KHK protein with other proteins. These features can also be used to develop new biomarkers and drug targets.

Customer Reviews (3)

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Reviews
12/03/2020

    Due to the short half-life and high clearance characteristics of KHK, they can better adapt to the treatment needs of patients of different ages, providing patients with a safer and more effective treatment option.

    12/30/2019

      The stability of KHK is so good that it can be manipulated experimentally for long periods of time without compromising its performance and results.

      09/19/2019

        Reproducibility of the Western blot was significantly improved by using this protein.

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