"ADRA2B" Related Products

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Recombinant Human ADRA2B, His-tagged

Cat.No.: ADRA2B-3332H
Product Overview: Alpha-2B adrenergic receptor (ADRA2B)
Description: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.
Source: E. Coli or Yeast
Species: Human
Tag: His
Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length: 450
Purity: >90%
Notes: Small volumes of ADRA2B recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer: PBS pH 7.4, 50% glycerol
Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name: ADRA2B adrenergic, alpha-2B-, receptor [ Homo sapiens ]
Official Symbol: ADRA2B
Synonyms: ADRA2B; adrenergic, alpha-2B-, receptor; ADRA2L1, ADRA2RL1; alpha-2B adrenergic receptor; ADRARL1; alpha-2BAR; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; G-protein coupled receptor; adrenergic receptor alpha 2B; alpha-2B-adrenergic receptor; alpha-2-adrenergic receptor-like 1; ADRA2B adrenergic, alpha-2B-, receptor; alpha-2 adrenergic receptor subtype C2; ADRA2L1; ADRA2RL1; ALPHA2BAR;
Gene ID: 151
mRNA Refseq: NM_000682
Protein Refseq: NP_000673
MIM: 104260
UniProt ID: P18089
Chromosome Location: 2q11.1
Pathway: Adrenaline signalling through Alpha-2 adrenergic receptor, organism-specific biosystem; Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosys
Function: G-protein coupled receptor activity; adrenergic receptor activity; alpha2-adrenergic receptor activity; epinephrine binding; protein binding; receptor activity; signal transducer activity;

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