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Recombinant Human ANK1, His-tagged

Cat.No. : ANK1-3490H
Product Overview : Ankyrin-1 (ANK1), partial
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  • Gene Information
  • Related Products
Description : Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
Source : E. Coli or Yeast
Species : Human
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 1880
Purity : >90%
Notes : Small volumes of ANK1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : ANK1 ankyrin 1, erythrocytic [ Homo sapiens ]
Official Symbol : ANK1
Synonyms : ANK1; ankyrin 1, erythrocytic; ANK; ankyrin-1; SPH1; ANK-1; ankyrin-R; erythrocyte ankyrin; SPH2;
Gene ID : 286
mRNA Refseq : NM_000037
Protein Refseq : NP_000028
MIM : 612641
UniProt ID : P16157
Chromosome Location : 8p21.1-p11.2
Pathway : Axon guidance, organism-specific biosystem; CHL1 interactions, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosyst
Function : cytoskeletal adaptor activity; cytoskeletal adaptor activity; enzyme binding; protein binding; spectrin binding; spectrin binding; structural constituent of cytoskeleton; structural molecule activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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What research is currently being conducted on ANK1-related disorders? 11/30/2022

Ongoing research on ANK1-related disorders focuses on understanding the underlying molecular mechanisms, exploring the full spectrum of associated symptoms and complications, developing better diagnostic methods, and investigating potential targeted therapies. Researchers are also studying the role of ANK1 in other diseases, such as cardiovascular disorders and neurological conditions.

Can ANK1 mutations cause other types of diseases besides those mentioned earlier? 11/20/2022

While ANK1 mutations are most commonly associated with conditions affecting red blood cells, recent studies have also identified their potential involvement in other disorders. For example, ANK1 mutations have been implicated in hereditary spherocytosis-associated gallstones and an increased risk of gallbladder cancer. Moreover, there is evidence suggesting ANK1 gene variations may contribute to susceptibility to certain cardiovascular diseases, such as atrial fibrillation and myocardial infarction. However, further research is required to ascertain the precise role of ANK1 mutations in these conditions.

What are the potential functions of ANK1 protein besides its role in red blood cells? 04/08/2022

While ANK1 is well-known for its importance in maintaining the shape and stability of red blood cells, recent research has unveiled its involvement in various other cellular processes. ANK1 has been found in the brain, where it interacts with components of the cytoskeleton and contributes to the organization and function of nerve cells. Additionally, ANK1 is present in skeletal muscles and has been implicated in the development and maintenance of muscle structure. These findings suggest that ANK1 may have diverse functions beyond the red blood cell membrane.

What are the long-term complications or health risks associated with ANK1-related disorders? 12/15/2021

The long-term complications and health risks associated with ANK1-related disorders primarily depend on the specific disorder and its severity. In hereditary spherocytosis and related conditions, individuals may experience chronic anemia, jaundice, gallstones, and an increased risk of serious infections.

Are there any specific drugs or compounds that can modulate ANK1 activity? 04/21/2021

At present, there are no specific drugs or compounds available that specifically target ANK1 activity. However, researchers are actively investigating potential small molecules or compounds that could modulate ANK1 function. These studies aim to identify molecules that could interact with ANK1 or associated pathways to potentially develop targeted therapies for diseases associated with ANK1 dysfunction.

Are there any treatment options available for ANK1-related disorders? 07/27/2020

The treatment options for ANK1-related disorders depend on the specific disorder and its severity. In milder cases, regular monitoring of blood cell counts and managing symptoms, such as anemia, may be sufficient. For individuals with more severe symptoms, treatment may involve blood transfusions to address chronic anemia or surgical removal of the gallbladder in cases of gallstones. In some cases, splenectomy (surgical removal of the spleen) may be necessary to manage complications such as splenomegaly or to decrease the destruction of red blood cells. Genetic counseling is also recommended for affected individuals and their families to discuss the inheritance pattern and assess the risk of passing on the mutation.

Can ANK1 protein be targeted for therapeutic purposes? 05/07/2019

Currently, there are no specific therapies targeting ANK1 protein. However, research efforts are underway to explore potential therapeutic strategies. In the case of hereditary spherocytosis and related disorders, treatment mainly focuses on managing the symptoms, such as anemia, through blood transfusions or splenectomy. Gene therapy approaches that aim to correct or replace the defective ANK1 gene are also being investigated as potential future treatments.

Are there any other functions or roles of ANK1 protein? 03/04/2019

Apart from its role in maintaining cell shape and integrity, ANK1 protein has also been implicated in other cellular processes. It has been shown to interact with various ion channels and transporters, participating in the regulation of cell volume, membrane potential, and signal transduction in specific cell types. Additionally, ANK1 has been identified as a tumor suppressor gene and has been associated with certain types of cancer. However, further research is needed to fully understand these additional roles and their mechanisms.

Is there any ongoing research related to the ANK1 protein? 01/10/2019

Yes, there is ongoing research related to ANK1 protein. Scientists are studying the structure and function of ANK1 in more detail to gain a deeper understanding of its role in cellular processes and diseases. They are also investigating potential therapeutic approaches that target ANK1 or associated pathways. Additionally, further research is being conducted to explore the involvement of ANK1 in cancer development and progression.

What happens if ANK1 protein is dysfunctional? 06/17/2018

Mutations in the ANK1 gene can cause various forms of hereditary spherocytosis, a condition characterized by abnormal red blood cell morphology leading to hemolytic anemia. In these cases, the ANK1 protein is either partially or completely deficient, leading to weakened interaction between the cytoskeleton and the plasma membrane, resulting in the loss of cell membrane integrity and increased susceptibility to cell rupture.

Are there any diseases other than hereditary spherocytosis associated with ANK1 protein? 10/09/2017

Apart from hereditary spherocytosis, ANK1 mutations have been associated with other related conditions, such as hereditary elliptocytosis and pyropoikilocytosis. These conditions involve abnormal red blood cell morphology, similar to spherocytosis. ANK1 mutations have also been linked to a rare neurological disorder known as spinocerebellar ataxia type 37 (SCA37), characterized by progressive cerebellar degeneration and ataxia. Additionally, there is emerging research suggesting a potential role of ANK1 in certain types of cancer, although more studies are needed to establish a clear association.

How common are ANK1-related disorders? 12/24/2016

ANK1-related disorders, such as hereditary spherocytosis, are considered relatively rare. The exact prevalence is difficult to determine, as the disorder can vary in severity and may be underdiagnosed due to mild or atypical symptoms. It has been estimated that hereditary spherocytosis occurs in approximately 1 in 2,000 to 5,000 individuals, with some populations having higher prevalence rates. Other ANK1-related conditions, such as elliptocytosis, are even rarer. However, advances in genetic testing and increased awareness may lead to more accurate prevalence estimates in the future.

Can ANK1 mutations be inherited? 05/11/2016

Yes, ANK1 mutations can be inherited in an autosomal dominant or autosomal recessive manner. In autosomal dominant inheritance, only one copy of the mutated ANK1 gene is necessary for the disorder to be inherited. This means that if a person has an affected parent, they have a 50% chance of inheriting the mutated gene and developing the disorder. In autosomal recessive inheritance, both copies of the ANK1 gene must be mutated for the disorder to be inherited. This means that both parents must be carriers of a mutated gene, and each child has a 25% chance of inheriting the disorder.

Customer Reviews (4)

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Reviews
02/22/2022

    With their support, I can confidently explore the intricacies of ANK1 and make significant contributions to the understanding of its functions in various biological processes.

    05/26/2020

      The manufacturer's excellent technical support, commitment to innovation, and customer-centric approach further reinforce its suitability for my research.

      08/27/2019

        This existing knowledge base provides a solid foundation for designing experiments and interpreting results, ultimately enhancing the efficiency and reliability of trials involving ANK1 protein.

        03/03/2018

          Extensive research has been conducted on ANK1, making it relatively accessible and well-understood in terms of its structure and functions.

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