| Cat.No.: | PLF4-88H |
| Description: | Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues |
| Source: | Human platelets |
| Species: | Human |
| Form: | Lyophilized protein |
| Bio-activity: | Binding of HIT-antibodies |
| Molecular Mass: | 7.8 kDa |
| AA Sequence: | The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu |
| Purity: | Purity by SDS-PAGE: ≥95%; Purity by HPLC: ≥95% |
| Usage: | For Research Use Only! Not For Use in Humans. |
| Notes: | Centrifuge the vial prior to opening |
| Storage: | -20°C |
| Storage Buffer: | Lyophilized from PBS buffer, pH 7.4 |
| Reconstitution: | Reconstitute in sterile ddH?O to a concentration ≥ 100 μg/ml. This solution can then be diluted into other aqueous buffers |
| Shipping: | Gel pack |
| Gene Name: | PF4 platelet factor 4 [ Homo sapiens ] |
| Official Symbol: | PLF4 |
| Synonyms: | PF-4; CXCL4; SCYB4; platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4 |
| Gene ID: | 5196 |
| mRNA Refseq: | NM_002619 |
| Protein Refseq: | NP_002610 |
| MIM: | 173460 |
| UniProt ID: | P02776 |
| Chromosome Location: | 4q12-q21 |
| Pathway: | CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Common Pathway, organism-specific biosystem |
| Function: | CXCR3 chemokine receptor binding; chemokine activity |
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