| Species : |
Human |
| Source : |
Human Platelets |
| Tag : |
Non |
| Description : |
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues |
| Form : |
Lyophilized protein |
| Bio-activity : |
Binding of HIT-antibodies |
| Molecular Mass : |
7.8 kDa |
| AA Sequence : |
The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu |
| Purity : |
Purity by SDS-PAGE: ≥95%; Purity by HPLC: ≥95% |
| Usage : |
For Research Use Only! Not For Use in Humans. |
| Notes : |
Centrifuge the vial prior to opening |
| Storage : |
-20°C |
| Storage Buffer : |
Lyophilized from PBS buffer, pH 7.4 |
| Reconstitution : |
Reconstitute in sterile ddH?O to a concentration ≥ 100 μg/ml. This solution can then be diluted into other aqueous buffers |
| Shipping : |
Gel pack |
