Active Native Human PF 4
| Cat.No. : | PLF4-88H |
- Specification
- Gene Information
- Related Products
| Description : | Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues |
| Source : | Human platelets |
| Species : | Human |
| Form : | Lyophilized protein |
| Bio-activity : | Binding of HIT-antibodies |
| Molecular Mass : | 7.8 kDa |
| AA Sequence : | The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu |
| Purity : | Purity by SDS-PAGE: ≥95%; Purity by HPLC: ≥95% |
| Usage : | For Research Use Only! Not For Use in Humans. |
| Notes : | Centrifuge the vial prior to opening |
| Storage : | -20°C |
| Storage Buffer : | Lyophilized from PBS buffer, pH 7.4 |
| Reconstitution : | Reconstitute in sterile ddH?O to a concentration ≥ 100 μg/ml. This solution can then be diluted into other aqueous buffers |
| Shipping : | Gel pack |
| Gene Name : | PF4 platelet factor 4 [ Homo sapiens ] |
| Official Symbol : | PLF4 |
| Synonyms : | PF-4; CXCL4; SCYB4; platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4 |
| Gene ID : | 5196 |
| mRNA Refseq : | NM_002619 |
| Protein Refseq : | NP_002610 |
| MIM : | 173460 |
| UniProt ID : | P02776 |
| Chromosome Location : | 4q12-q21 |
| Pathway : | CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Common Pathway, organism-specific biosystem |
| Function : | CXCR3 chemokine receptor binding; chemokine activity |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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