Native Bovine glu-Plasminogen


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Native Bovine glu-Plasminogen

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Cat.No. : PLG-268B
Description : Plasminogen is a single chain glycoprotein zymogen which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 μM. The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls and 5 regions of internal sequence homology, known as kringles, between Lys77 and Arg560. These five triple-looped, three disulfide bridged, kringle regions are homologous to the kringle domains in t-PA, u-PA and prothrombin. Plasminogen contains one high affinity (Kd=9x10-6M) and four low affinity (Kd=5x10-3M) lysine binding sites. The high affinity binding site resides within the first kringle region of plasminogen. The interaction of plasminogen with fibrin and α2-antiplasmin is mediated by these lysine binding sites. Native glu-plasminogen (Mr=88,000) is readily converted to Lys-77-plasminogen (Mr=83,000) by plasmin hydrolysis of the Lys76-Lys77 peptide bond. Elastase catalyzed cleavage of the Val441-Val442 peptide bond of glu-plasminogen yields a functionally active zymogen termed Val-442 plasminogen or mini-plasminogen.
Source : Plasma
Species : Bovine
Form : 50% (vol/vol) glycerol/H2O
Bio-activity : < 10 ppm plasmin activity for>
Purity : >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin.
Characteristic : Extinction coefficient: 17.0, Isoelectric point:6.2, Percent carbohydrate: Approximately 2%, Structure:single chain, 24 intra chain disulfide bridges, 5 kringle regions
Storage : -20°C
Gene Name : PLG plasminogen [ Bos taurus ]
Official Symbol : PLG
Synonyms : LPA; plasminogen; plasmin; lipoprotein, Lp(a)
Gene ID : 280897
mRNA Refseq : NM_173951
Protein Refseq : NP_776376
UniProt ID : P06868
Chromosome Location : chromosome: 9
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem
Function : protein binding; serine-type endopeptidase activity

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