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Recombinant Chicken AKAP2

Cat.No. : AKAP2-4498C
Product Overview : Recombinant Chicken AKAP2 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Chicken
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : AKAP2 A kinase (PRKA) anchor protein 2 [ Gallus gallus (chicken) ]
Official Symbol : AKAP2
Gene ID : 100533110
Protein Refseq : NP_001191146
UniProt ID : E1C929

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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Is AKAP2 involved in any specific cellular processes? 10/01/2022

AKAP2 is involved in various cellular processes, including regulation of PKA-mediated phosphorylation events, modulation of cAMP-dependent signaling pathways, and localization of PKA to specific subcellular compartments.

Does AKAP2 have any known functional domains? 06/12/2022

Yes, AKAP2 contains several functional domains. The N-terminal domain contains a PKA-binding site, allowing its interaction with PKA regulatory subunits. The central leucine-rich repeat region is involved in protein-protein interactions, potentially mediating interactions with other proteins. The C-terminal domain also contributes to protein-protein interactions and may have additional functional roles.

Are there any AKAP2 knockout or knockdown studies? 03/18/2022

There have been limited studies involving AKAP2 knockout or knockdown. However, preliminary research using animal models and cell-based studies suggest that AKAP2 plays important roles in neuronal development, cardiac function, and cell signaling. Future research involving AKAP2 manipulation could provide further insights into its functions and potential therapeutic applications.

Is AKAP2 expressed in all tissues or organs? 01/16/2022

AKAP2 is widely expressed in various tissues and organs, although its expression levels may vary among different cell types. It is expressed in the brain, heart, skeletal muscle, liver, kidney, lung, and other tissues. Its expression pattern suggests that AKAP2 is involved in multiple physiological processes throughout the body.

What are the physiological functions of AKAP2? 10/31/2021

AKAP2 is involved in the regulation of a variety of physiological processes. It plays a crucial role in mediating PKA-dependent signaling pathways by anchoring PKA to specific subcellular compartments. This allows for precise spatial and temporal regulation of PKA activity and subsequent phosphorylation of target proteins. AKAP2 has been implicated in the regulation of cardiac function, neuronal development, synaptic plasticity, neurotransmitter release, and dendritic spine maintenance.

Are there any known diseases associated with mutations in AKAP2? 10/13/2021

Currently, there are no known diseases directly associated with mutations in AKAP2. However, dysregulation of AKAP2 expression or function may contribute to various cellular dysfunctions and diseases.

Can AKAP2 be targeted for therapeutic interventions? 02/25/2021

Given its involvement in cellular processes and signaling pathways, AKAP2 could potentially be targeted for therapeutic interventions. However, further research is required to fully understand its exact role and potential therapeutic implications.

Is AKAP2 associated with any specific signaling pathways? 02/18/2020

AKAP2 is primarily known for its role in modulating PKA-mediated signaling pathways. It facilitates the spatial and temporal regulation of PKA activity by anchoring PKA to specific subcellular compartments. As a result, AKAP2 can influence various downstream signaling pathways that are regulated by PKA, including cAMP-dependent pathways.

Are there any disease-associated mutations in the AKAP2 gene? 03/23/2019

At present, there have been no disease-associated mutations reported in the AKAP2 gene. However, considering its involvement in various cellular processes and the emerging role of AKAPs in disease pathogenesis, it is possible that future studies may uncover disease-associated mutations or genetic variants in the AKAP2 gene.

Are there any AKAP2 inhibitors or activators? 07/22/2018

Currently, there are no known specific inhibitors or activators targeting AKAP2. However, the development of small-molecule inhibitors or activators that selectively modulate AKAP2's interactions or functions could hold potential for future therapeutic interventions. Further research is needed in this area.

Can AKAP2 be used as a biomarker? 06/22/2018

Currently, there is limited research on using AKAP2 as a biomarker. However, as AKAP2 has been implicated in various cellular processes and dysregulation of its expression or function may contribute to disease progression, it is worth exploring its potential as a biomarker in specific diseases or conditions.

Does AKAP2 have any functional roles in the nervous system? 01/27/2017

Yes, AKAP2 has been implicated in neuronal development and synaptic signaling. It may play a role in the regulation of neuronal plasticity, neurotransmitter release, and dendritic spine maintenance. However, more research is required to fully understand the precise mechanisms and functional significance of AKAP2 in the nervous system.

Is AKAP2 protein conserved across species? 08/30/2016

Yes, AKAP2 protein is highly conserved across species, indicating its importance in cellular processes.

Does AKAP2 interact with any other proteins? 03/30/2016

Yes, AKAP2 interacts with several proteins, including PKA regulatory subunits, phosphodiesterase 4D (PDE4D), and A-kinase anchor protein 1 (AKAP1). These interactions enable the formation of protein complexes involved in signaling pathways.

Can AKAP2 be targeted for therapeutic interventions? 02/29/2016

Although there are no specific therapeutic interventions targeting AKAP2 currently available, its role in signaling pathways and its potential involvement in disease progression make it an interesting target for future research. Modulation of AKAP2's interactions or functions could hold therapeutic potential for certain diseases, including neurological disorders, cardiac disorders, and cancer. Further studies are needed to fully explore the therapeutic opportunities related to AKAP2.

Can AKAP2 interact with other AKAPs? 12/16/2015

There is limited information on the direct interaction between AKAP2 and other AKAPs. However, there is evidence to suggest that AKAP2 can form complexes with other AKAPs and participate in multiprotein signaling complexes. These interactions may help coordinate the spatial organization of signaling molecules and promote efficient signal transduction within cells.

Are there any known AKAP2 binding partners in the mitochondria? 11/10/2015

Although AKAP2 is primarily localized in the cytoplasm, there is evidence of its presence in the mitochondria. However, the specific binding partners of AKAP2 in the mitochondria are not well-characterized. Further research is needed to identify and understand the functional significance of AKAP2's interactions in this organelle.

Is there any evidence of AKAP2 involvement in cancer? 10/27/2015

There is currently limited research on the role of AKAP2 in cancer. However, some studies have suggested that dysregulation of AKAP2 expression could contribute to cancer progression or prognosis in certain types of cancer. Further investigation is needed to fully understand its involvement in cancer biology.

Can AKAP2 expression be regulated? 04/22/2015

Yes, AKAP2 expression can be regulated at the transcriptional level. It has been shown that various signaling pathways and transcription factors can modulate AKAP2 expression. However, the exact mechanisms and regulatory elements involved in AKAP2 gene expression are still not fully understood.

What research has been done on AKAP2 protein? 04/02/2015

Several studies have investigated the role of AKAP2 in intracellular signaling, neuronal development, and cardiac function. These studies have shed light on its structural organization, interacting partners, and functional significance in various biological processes.

Are there any known post-translational modifications of AKAP2? 04/01/2015

There is limited information available on post-translational modifications of AKAP2. However, phosphorylation of AKAP2 by PKA has been reported, suggesting that it may undergo post-translational modifications to regulate its activity or interactions with other proteins.

Customer Reviews (4)

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Reviews
06/11/2022

    Their commitment to customer satisfaction inspires confidence, knowing that I have the necessary support to overcome any hurdles along the way.

    04/17/2020

      the manufacturer excels in providing outstanding technical support, offering invaluable assistance in troubleshooting any challenges that may arise.

      09/06/2019

        the AKAP2 protein's unwavering quality, coupled with exceptional technical support from the manufacturer, makes it the optimal choice for my research needs.

        07/19/2017

          The manufacturer's knowledgeable and responsive team of experts is readily available to address any concerns or queries, ensuring a seamless experimental process.

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