Recombinant Human TPM3, MYC/DDK-tagged TPM3-29H

Recombinant Human TPM3, MYC/DDK-tagged

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Recombinant Human TPM3, MYC/DDK-tagged

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Cat.No. : TPM3-29H
Product Overview : Recombinant Human TPM3, transcript variant 2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description : This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Molecular Mass : 28.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Figure :

Gene Name : TPM3 tropomyosin 3 [ Homo sapiens (human) ]
Official Symbol : TPM3
Synonyms : TPM3; tropomyosin 3; NEM1; tropomyosin alpha-3 chain; TRK; tropomyosin-3; tropomyosin-5; gamma-tropomyosin; tropomyosin gamma; cytoskeletal tropomyosin TM30; heat-stable cytoskeletal protein 30 kDa; TM3; TM5; CFTD; TM-5; TM30; hTM5; TM30nm; TPMsk3; hscp30; OK/SW-cl.5; MGC3261; FLJ41118; MGC14582; MGC72094
Gene ID : 7170
mRNA Refseq : NM_153649
Protein Refseq : NP_705935
MIM : 191030
UniProt ID : P06753
Chromosome Location : 1q21.2
Pathway : Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM); Smooth Muscle Contraction
Function : actin binding; molecular_function

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