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Active Recombinant Human LGALS9 protein

Cat.No. : LGALS9-443H
Product Overview : Recombinant Human LGALS9(Ala2-Thr323) was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Human
Predicted N Terminal : Ala2
Form : Lyophilized from a 0.2 μm filtered solution in MOPS, NaCl, EDTA, DTT and Trehalose.
Bio-activity : Measured by its ability to induce apoptosis of Jurkat human acute T cell leukemia cells. Lu, L.H. et al. (2007) J. Biochem. 141:157. The ED50 for this effect is typically 1-5 μg/mL. Measured by its ability to agglutinate human red blood cells. Hadari, Y.R. et al. (2000) J. Cell Sci. 113:2385. The ED50 for this effect is typically 2.5-12.5 µg/mL.
Molecular Mass : Predicted Molecular Mass: 35.8 kDa;SDS-PAGE: 34 kDa, reducing conditions.
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in water.
Gene Name : LGALS9 lectin, galactoside-binding, soluble, 9 [ Homo sapiens ]
Official Symbol : LGALS9
Synonyms : LGALS9; lectin, galactoside-binding, soluble, 9; galectin-9; galectin 9; LGALS9A; gal-9; ecalectin; tumor antigen HOM-HD-21; urate transporter/channel protein; HUAT; MGC117375; MGC125973; MGC125974;
Gene ID : 3965
mRNA Refseq : NM_002308
Protein Refseq : NP_002299
MIM : 601879
UniProt ID : O00182
Chromosome Location : 17q11.2
Pathway : 1. Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker. Chen DY, et al. BMC Med, 2012 Aug 6. 2. MAP4K3 enhances the expression of the BH3-only protein BID. Lam D, et al. Cell Cycle, 2009 Oct 15. 3. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Diener K, et al. Proc Natl Acad Sci U S A, 1997 Sep 2.
Function : galactose binding; signal transducer activity; sugar binding; sugar binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials involving LGALS9 protein? 04/12/2023

Yes, there are clinical trials investigating the use of LGALS9-based therapies in cancer treatment, with a focus on immunotherapy approaches.

Is LGALS9 protein being explored for the treatment of infectious diseases? 07/05/2022

There is emerging research on the potential use of LGALS9 in modulating immune responses to infectious diseases, particularly in the context of viral infections.

What are the potential challenges associated with the clinical application of LGALS9 protein? 03/28/2021

Challenges include optimizing the delivery and dosing of LGALS9-based therapies and addressing potential adverse effects on immune homeostasis.

How is LGALS9 protein being studied in the context of transplant immunology? 01/08/2020

LGALS9 is being investigated for its potential to induce immune tolerance and mitigate transplant rejection in preclinical studies.

How does LGALS9 protein contribute to cancer immunotherapy? 12/31/2019

LGALS9 has been found to promote the activation and proliferation of cytotoxic T lymphocytes, which are key players in the immune response against cancer cells.

Customer Reviews (3)

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Reviews
08/04/2019

    It has demonstrated outstanding performance in ELISA, providing reliable and precise results.

    05/05/2019

      It has been invaluable in protein electron microscopy structure analysis, facilitating detailed investigations and yielding valuable insights.

      03/09/2016

        I highly recommend the LGALS9 protein for various experimental applications.

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