Mad2-p31(comet) complex CBCRY03

Mad2-p31(comet) complex

PRODUCTS

Home / Products / Others / Mad2-p31(comet) complex

Mad2-p31(comet) complex

Mad2-p31(comet) complex Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : CBCRY03
Background : The crystal structure of the Mad2-p31(comet) complex is reported. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2."
Protein Classification : cell cycle
Structure Weight : 105471.24 Da
Polymer : 1
Molecule : Mitotic spindle assembly checkpoint protein MAD2A
Chain Length : 210 amino acids
PDB ID : 2QYF
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.30 Å
Modified residues : selenomethionine (pareint: MET)
Reference : Yang, M., Li, B., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. p31comet blocks Mad2 activation through structural mimicry.Cell(Cambridge,Mass.)2007; 131: 744-755
Gene Name : MAD2L1
Synonyms : HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1
UniProt ID : Q13257
Chromosome Location : 4q27
Function : protein binding
Gene ID : 9587

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy