Mad2-p31(comet) complex


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Mad2-p31(comet) complex

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Cat. No. : CBCRY03
Background : The crystal structure of the Mad2-p31(comet) complex is reported. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2."
Protein Classification : cell cycle
Structure Weight : 105471.24 Da
Polymer : 1
Molecule : Mitotic spindle assembly checkpoint protein MAD2A
Chain Length : 210 amino acids
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.30 Å
Modified residues : selenomethionine (pareint: MET)
Reference : Yang, M., Li, B., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. p31comet blocks Mad2 activation through structural mimicry.Cell(Cambridge,Mass.)2007; 131: 744-755
Gene Name : MAD2L1
Synonyms : HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1
UniProt ID : Q13257
Chromosome Location : 4q27
Function : protein binding
Gene ID : 9587
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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