"Mad2-p31(comet) complex" Related Products

Mad2-p31(comet) complex

Cat. No.: CBCRY03
Background: The crystal structure of the Mad2-p31(comet) complex is reported. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2."
Protein Classification: cell cycle
Structure Weight: 105471.24 Da
Polymer: 1
Molecule: Mitotic spindle assembly checkpoint protein MAD2A
Chain Length: 210 amino acids
PDB ID: 2QYF
Source: E.coli
Method: X-Ray Diffraction
Resolution: 2.30 Å
Modified residues: selenomethionine (pareint: MET)
Reference: Yang, M., Li, B., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. p31comet blocks Mad2 activation through structural mimicry.Cell(Cambridge,Mass.)2007; 131: 744-755
Gene Name: MAD2L1
Synonyms: HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1
UniProt ID: Q13257
Chromosome Location: 4q27
Function: protein binding
Gene ID: 9587

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