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||Interferon β is one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity. The synthesis of IFN-β can be induced by common inducers of interferons, including viruses, double-stranded RNA, and microorganisms. It is induced also by some cytokines such as TNF and IL-1. Recombinant human IFN-β 1b produced inE. coliis a single, non-glycosylated form of human Interferon β1b polypeptide chain containing 165 amino acids and having a molecular mass of 18.511 kDa. The Interferon β gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine residue found at position 17. IFN- 1b is purified by proprietary chromatographic techniques.
||Less than 0.1 ng/μg (IEU/μg) of IFN-β.
||≥98% by SDS-PAGE, RP-HPLC and FPLC.
||It is recommended to reconstitute the lyophilized IFN-β in sterile bidest H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
||EC50: 3.2 x 107IU/mg, determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus).
||Quality guaranteed for 12 months. Store at -20°C.Avoid freeze / thaw cycles.
||For in vitro use only.