Recombinant Human General Transcription Factor IIH, Polypeptide 1, 62kDa GTF2H1-1187H

Recombinant Human General Transcription Factor IIH, Polypeptide 1, 62kDa

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Human General Transcription Factor IIH, Polypeptide 1, 62kDa

Recombinant Human General Transcription Factor IIH, Polypeptide 1, 62kDa

GTF2H1 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : GTF2H1-1187H
Description : TFIIH, a multisubunit complex is involved in several biological fundamental mechanisms of the cell: transcription, nucleotide excision repair, and cell cycle regulation. p62 is one of the six subunits that constitutes the core of TFIIH. Analysis of the expression of the p62 gene reveals an over-expression in testis tissue. This subunit of TFIIH participates in a variety of protein-protein interactions. For example, Rb competes with TBP and p62 for binding to E2F thus repressing E2F-mediated transactivation, herpes simplex virus VP16 and human p53, directly interact with the p62 subunit of TFIIH. In addition, TFIIH, via p62 phosphorylation is the major target for mitotic inactivation of transcription. Recombinant p62 protein is isolated from anE. colistrain that carries the coding sequence of human p62 under the control of a T7 promoter. p62 has been used for protein-protein interactions assays.Protein is greater than 95% homogeneous and contains no detectable protease, DNase, and RNase activity.
Source : E. coli.
Purity : > 95% by SDS-PAGE.
Form : Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 Mm KCl, 0.2 mM EDTA, 1 mM DTT, 20% glycerol.
Activity : 100 ng are sufficient for a protein-protein interaction assay.
Storage : Quality guaranteed for 12 months. Store at-80°C. Avoid freeze / thaw cycles.
Usage : For in vitro use only.
PDB rendering based on 1pfj. :

Gene Name : GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa [ Homo sapiens ]
Synonyms : general transcription factor IIH, polypeptide 1, 62kDa; BTF2; TFB1; TFIIH; GTF2H1; general transcription factor IIH, polypeptide 1 (62kD subunit); BTF2-p62; Basic transcription factor 2 62 kDa subunit; General transcription factor IIH polypeptide 1; TFIIH basal transcription factor complex p62 subunit
Gene ID : 2965
mRNA Refseq : NM_001142307
Protein Refseq : NP_001135779
MIM : 189972
UniProt ID : P32780
Chromosome Location : 11p15.1-p14
Pathway : Basal transcription factors; Nucleotide excision repair; DNA Repair; Gene Expression; HIV Infection; Transcription; mRNA Processing
Function : RNA polymerase II carboxy-terminal domain kinase activity; general RNA polymerase II transcription factor activity; DNA-dependent ATPase activity; protein binding; protein kinase activity

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy