"MARK1" Related Products


Recombinant Human MARK1, GST-tagged, Active

Cat. No. : MARK1-348H
Product Overview : Recombinant full-length human MARK1 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 125 kDa.
Description : MARK1 is a member of the MARK family and is a serine/threonine-protein kinase that plays a key role in signal transduction. Due to its protein serine/threonine kinase activity, MARK1 is known to mediate phosphorylation of key proteins involved in signal transduction and cell communication. MARK1 phosphorylates microtubule-associated proteins and trigger microtubule disruption. Gene mutation studies performed in mice revealed that after targeted disruption of the MARK1 gene, the mice lacked the ability to drink, and displayed hind leg motor dysfunction.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 2hak. :

Gene Name : MARK1 MAP/microtubule affinity-regulating kinase 1 [ Homo sapiens ]
Synonyms : MARK1; MAP/microtubule affinity-regulating kinase 1; MARK; KIAA1477; MGC126512; MGC126513; EC; OTTHUMP00000035458; Serine/threonine-protein kinase MARK1
Gene ID : 4139
mRNA Refseq : NM_018650
Protein Refseq : NP_061120
MIM : 606511
UniProt ID : Q9P0L2
Chromosome Location : 1q41
Function : ATP binding; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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