Recombinant Human BCL2-associated Agonist Of Cell Death, GST-tagged
| Cat.No. : |
BAD-1433H |
| Product Overview : |
Recombinant full-length human BAD was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 47kDa. |
- Specification
- Gene Information
- Related Products
| Cat. No. : |
BAD-1433H |
| Description : |
BAD is a member of the BCL-2 family of proteins that are known to be regulators of programmed cell death. BAD is a pro-apoptotic protein that forms a heterodimer complex with BCL-xL and BCL-2 which reverses the prosurvival activity of these proteins. The proapoptotic activity of BAD is regulated through its phosphorylation and this inhibits the pro-apoptosis function of BAD. Protein kinases such as AKT, RAF and RSK1 can phosphorylate BAD and RSK1-induced phosphorylation of BAD at ser112 suppresses BAD-mediated apoptosis in neurons. BAD inhibits G(1) to S phase transition in MCF7 breast cancer cells and overexpression of BAD inhibits cell growth as well as cyclin D1 expression. |
| Source : |
Sf9 insect cells using baculovirus. |
| Sequence : |
Full length. |
| Applications : |
Western Blot. |
| Storage And Stability : |
Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : |
BAD BCL2-associated agonist of cell death [ Homo sapiens ] |
| Synonyms : |
BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2- associated death promoter |
| Gene ID : |
572 |
| mRNA Refseq : |
NM_004322 |
| Protein Refseq : |
NP_004313 |
| MIM : |
603167 |
| UniProt ID : |
Q92934 |
| Chromosome Location : |
11q13.1 |
| Pathway : |
cute myeloid leukemia; Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Chronic myeloid leukemia; Endometrial cancer; ErbB signaling pathway; Focal adhesion; Insulin signaling pathway; Melanoma; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pancreatic cancer; thways in cancer; VEGF signaling pathway; Apoptosis |
| Function : |
protein binding; protein kinase binding |
Products Types
Related Gene
BAD
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