Recombinant Human BCL2-associated Agonist Of Cell Death, GST-tagged

• Cat.No.: BAD-1433H
• Product Overview: Recombinant full-length human BAD was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 47kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: BAD is a member of the BCL-2 family of proteins that are known to be regulators of programmed cell death. BAD is a pro-apoptotic protein that forms a heterodimer complex with BCL-xL and BCL-2 which reverses the prosurvival activity of these proteins. The proapoptotic activity of BAD is regulated through its phosphorylation and this inhibits the pro-apoptosis function of BAD. Protein kinases such as AKT, RAF and RSK1 can phosphorylate BAD and RSK1-induced phosphorylation of BAD at ser112 suppresses BAD-mediated apoptosis in neurons. BAD inhibits G(1) to S phase transition in MCF7 breast cancer cells and overexpression of BAD inhibits cell growth as well as cyclin D1 expression.
• Sequence: Full length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: BAD BCL2-associated agonist of cell death [ Homo sapiens ]
• Synonyms: BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2- associated death promoter
• Gene ID: 572
• mRNA Refseq: NM_004322
• Protein Refseq: NP_004313
• MIM: 603167
• UniProt ID: Q92934
• Chromosome Location: 11q13.1
• Pathway: cute myeloid leukemia; Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Chronic myeloid leukemia; Endometrial cancer; ErbB signaling pathway; Focal adhesion; Insulin signaling pathway; Melanoma; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pancreatic cancer; thways in cancer; VEGF signaling pathway; Apoptosis
• Function: protein binding; protein kinase binding