Native Human CPB2

• Cat.No.: CPB2-27270TH
• Product Overview: Full length native protein , corresponding to amino acids 23-423 of Human Carboxypeptidase B2.

Specification

• Description: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Available sequence data analyses indicate splice variants that encode different isoforms.
• Protein length: 400 amino acids
• Biological activity: Specific Activity: 2.0-9.2 units/mg. Specific activity is determined by a kinetic assay using Hippuryl-L-Arginine as substrate.One unit equals one micromole of Hippuryl-L-Arginine hyrolyzed per minute.Specific activity is reported in Units per milligram.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM HEPES, 150mM Sodium chloride, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: CPB2 carboxypeptidase B2 (plasma) [ Homo sapiens ]
• Official Symbol: CPB2
• Synonyms: CPB2; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); carboxypeptidase B2; carboxypeptidase U; CPU; PCPB; TAFI; thrombin activatable fibrinolysis inhibitor
• Gene ID: 1361
• mRNA Refseq: NM_001872
• Protein Refseq: NP_001863
• MIM: 603101
• Uniprot ID: Q96IY4
• Chromosome Location: 13q14.11
• Pathway: Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem
• Function: metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding