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Recombinant Mouse Activin A Receptor, Type II-like 1, Fc-tagged

Cat. No.: Acvrl1-498M
Product overview: Recombinant Mouse Acvrl1 encoding the signal peptide from human CD33 joined with amino acid residues 23 - 119 of the extracellular domain of mouse Activin Receptor-Like Kinase 1was fused to the Fc region of human IgG1 via a polypeptide linker and expressed inNSO cells.
Description: Activin A receptor type II-like 1, also known as ACVRL1, is a human gene. ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as "activin receptor-like kinase 1", or "ALK1". This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 suggesting a critical role for ALK-1 in the control of blood vessel development or repair. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular regions.
Molecular Weight: The predicted molecular weight of Recombinant Mouse ALK-1 is Mr 37.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 50-55 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: Measured by its ability to inhibit recombinant Human BMP-9 induced alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is 20 - 80 ng/ml in the presence of 2 ng/ml of recombinant Human BMP-9.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Acvrl1 activin A receptor, type II-like 1 [ Mus musculus ]
Synonyms: Acvrl1; activin A receptor, type II-like 1; Alk1; Acvrlk1; AI115505; AI427544; activin A receptor type II-like 1; activin receptor-like kinase-1; EC 2.7.11.30; Alk-1
Gene ID: 11482
mRNA Refseq: NM_009612
Protein Refseq: NP_033742
UniProt ID: Q61288
Chromosome Location: 15 F3
Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function: ATP binding; activin receptor activity, type I; kinase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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