"GHR" Related Products

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Recombinant Human Growth Hormone Receptor

Cat. No.: GHR-1623H
Description: Growth hormone receptor, also known as GHR is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism).
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Molecular Weight: The predicted molecular weight of Recombinant Human GHR is Mr 54 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 75-90 kDa.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: GHR growth hormone receptor [ Homo sapiens ]
Synonyms: GHBP; GH receptor; Somatotropin receptor; GH receptor; Somatotropin receptor; growth hormone binding protein; growth hormone receptor; serum binding protein; GHR
Gene ID: 2690
mRNA Refseq: NM_000163
Protein Refseq: NP_000154
MIM: 600946
UniProt ID: P10912
Chromosome Location: 5p14-p12
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Neuroactive ligand-receptor interaction
Function: SH2 domain binding; growth hormone receptor activity; peptide hormone binding; receptor activity; phosphate binding; proline-rich region binding; protein kinase binding; protein homodimerization activity; protein phosphatase binding

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