"PSMB4" Related Products

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Recombinant Human PSMB4, His-tagged

Cat.No.: PSMB4-30367TH
Product Overview: Recombinant full length Human Proteasome subunit beta type 4 (amino acids 46-264) with an N terminal His tag; 240aa, 26.6kDa.
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
Protein length: 219 amino acids
Conjugation: HIS
Molecular Weight: 26.600kDa inclusive of tags
Source: E. coli
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 30% Glycerol, 0.02% DTT, 0.58% Sodium chloride
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMTQNPMVTGTSVLGVKFEGG VVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYAD FQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSR RSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLAT GYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYR DARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE
Sequence Similarities: Belongs to the peptidase T1B family.
Gene Name: PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 [ Homo sapiens ]
Official Symbol: PSMB4
Synonyms: PSMB4; proteasome (prosome, macropain) subunit, beta type, 4; proteasome subunit beta type-4; HN3; PROS26;
Gene ID: 5692
mRNA Refseq: NM_002796
Protein Refseq: NP_002787
MIM: 602177
Uniprot ID: P28070
Chromosome Location: 1q21
Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem;
Function: lipopolysaccharide binding; peptidase activity; threonine-type endopeptidase activity;

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