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Recombinant Mouse Fas Ligand (TNF Superfamily, Member 6)

Cat.No. : Fasl-1736M
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Cat. No. : Fasl-1736M
Description : Fas ligand (FasL) is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation. FasL is regarded as a potential target for immunotherapy.
Molecular Weight : The predicted molecular weight of Recombinant Mouse FasL is Mr 18 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 28-32 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Fasl Fas ligand (TNF superfamily, member 6) [ Mus musculus ]
Synonyms : Fasl; Fas ligand (TNF superfamily, member 6); gld; CD178; CD95L; Fas-L; Faslg; Tnfsf6; APT1LG1; Fas-Ligand; Fas antigen ligand; generalized lymphoproliferative disease; tumor necrosis factor (ligand) superfamily, member 6
Gene ID : 14103
mRNA Refseq : NM_010177
Protein Refseq : NP_034307
UniProt ID : P41047
Chromosome Location : 1 H2.1; 1 85.0 cM
Pathway : Allograft rejection; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Pathways in cancer; Type I diabetes mellitus
Function : cytokine activity; tumor necrosis factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there diagnostic tests that measure FASLG levels in clinical settings? 06/27/2019

Yes, there are diagnostic tests that measure FASLG levels, which can provide insights into immune function and disease processes.

In what ways can the FASLG protein be targeted for therapeutic purposes? 11/29/2018

The FASLG protein can be targeted for therapeutic purposes in cancer treatment and autoimmune disease management.

How is the FASLG protein involved in the pathogenesis of liver diseases? 09/17/2018

Dysregulation of FASLG expression can contribute to liver injury and the progression of liver diseases such as hepatitis and liver fibrosis.

How does the FASLG protein contribute to the pathogenesis of inflammatory bowel disease? 01/11/2018

Dysregulation of FASLG expression can impact intestinal immune homeostasis and contribute to the pathogenesis of inflammatory bowel disease.

What role does the FASLG protein play in organ transplantation? 01/17/2016

FASLG is involved in the regulation of immune responses to transplanted organs, and its dysregulation can impact transplant outcomes.

Customer Reviews (3)

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Reviews
06/06/2021

    The outstanding level of customer service adds extra reassurance and confidence in using the FASLG protein for my scientific investigations.

    06/20/2018

      the manufacturer of FASLG provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

      08/28/2017

        The FASLG protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

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