Recombinant Mouse Fas Ligand (TNF Superfamily, Member 6)

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Recombinant Mouse Fas Ligand (TNF Superfamily, Member 6)

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Cat. No. : Fasl-1736M
Description : Fas ligand (FasL) is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation. FasL is regarded as a potential target for immunotherapy.
Molecular Weight : The predicted molecular weight of Recombinant Mouse FasL is Mr 18 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 28-32 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Fasl Fas ligand (TNF superfamily, member 6) [ Mus musculus ]
Synonyms : Fasl; Fas ligand (TNF superfamily, member 6); gld; CD178; CD95L; Fas-L; Faslg; Tnfsf6; APT1LG1; Fas-Ligand; Fas antigen ligand; generalized lymphoproliferative disease; tumor necrosis factor (ligand) superfamily, member 6
Gene ID : 14103
mRNA Refseq : NM_010177
Protein Refseq : NP_034307
UniProt ID : P41047
Chromosome Location : 1 H2.1; 1 85.0 cM
Pathway : Allograft rejection; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Pathways in cancer; Type I diabetes mellitus
Function : cytokine activity; tumor necrosis factor receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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