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Recombinant Human ACACA, His-tagged

Cat.No. : ACACA-1848H
Product Overview : Recombinant Human ACC1 (amino acids 39 – end) with C-terminal His tag expressed inBaculovirusinfected Sf9 cellexpression system. MW= 292.5 kDa.
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Cat. No. : ACACA-1848H
Description : Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA.
Source : Baculovirus infected Sf9 cell.
Purity : >60%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Specific Activity : 0.33 pmol/min/μg Reaction buffer: 4 μM ATP, 50mM HEPES (pH 7.5), 2mM MgCl2, 2mM potassium citrate. Substrate= 20 μM acetyl-CoA and 12mM NaHCO3. Incubate 1h 30min at RT, add 50μl Kinase-Glo® Plus (Promega) to 50 μl of reaction and read luminescence.
Formulated In : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 3 mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 50% glycerol and 3mM DTT.
Stability : >12 months at -80°C.
Gene Name : ACACA acetyl-Coenzyme A carboxylase alpha [ Homo sapiens ]
Synonyms : acetyl-Coenzyme A carboxylase alpha; ACC; ACAC; ACC1; ACCA; ACACA; ACC-alpha; acetyl-CoA carboxylase 1; acetyl-CoA carboxylase-alpha;EC 6.4.1.2
Gene ID : 31
mRNA Refseq : NM_198834.1
Protein Refseq : NP_942131.1
MIM : 200350
UniProt ID : Q13085
Chromosome Location : 17q21
Pathway : Fatty acid biosynthesis; Insulin signaling pathway; Metabolic pathways; Propanoate metabolism; Pyruvate metabolism
Function : ATP binding; acetyl-CoA carboxylase activity; biotin binding; biotin carboxylase activity; ligase activity; metal ion binding; nucleotide binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the mechanism by which acetyl-CoA carboxylase alpha protein performs its function? 10/09/2022

Acetyl-CoA carboxylase alpha protein performs its function through the transfer of a carboxyl group from bicarbonate to acetyl-CoA.

What are the physiological and pathological roles of acetyl-CoA carboxylase alpha protein? 04/04/2020

Acetyl-CoA carboxylase alpha protein plays important roles in energy metabolism, fatty acid synthesis, and insulin signaling.

How is the expression of acetyl-CoA carboxylase alpha protein regulated? 11/26/2019

The expression of acetyl-CoA carboxylase alpha protein is regulated by transcriptional and post-transcriptional mechanisms.

What is the relationship between acetyl-CoA carboxylase alpha protein and lipid metabolism? 06/16/2018

Acetyl-CoA carboxylase alpha protein is closely involved in the regulation of lipid metabolism.

How does acetyl-CoA carboxylase alpha protein interact with other cellular components and signaling pathways? 05/29/2018

Acetyl-CoA carboxylase alpha protein interacts with various cellular components, including cytoskeletal proteins and membrane lipids.

What is the significance of acetyl-CoA carboxylase alpha protein in human health and disease? 04/04/2017

Acetyl-CoA carboxylase alpha protein is implicated in various human diseases, such as obesity, diabetes, and cancer.

What is the primary function of acetyl-CoA carboxylase alpha protein? 02/27/2017

The primary function of acetyl-CoA carboxylase alpha protein is to catalyze the conversion of acetyl-CoA to malonyl-CoA.

Are there any potential therapeutic targets or strategies that could modulate the activity of acetyl-CoA carboxylase alpha protein? 05/03/2016

Modulating the activity of acetyl-CoA carboxylase alpha protein is a potential therapeutic strategy for metabolic disorders and cancer.

What is the structure of acetyl-CoA carboxylase alpha protein? 09/27/2015

Acetyl-CoA carboxylase alpha protein is a multi-subunit enzyme with a biotin carboxylase domain and a carboxyltransferase domain.

What are the cellular and molecular pathways involved in the regulation of acetyl-CoA carboxylase alpha protein? 03/24/2015

The regulation of acetyl-CoA carboxylase alpha protein involves multiple cellular pathways, including AMPK and mTOR signaling.

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