"CASP10" Related Products

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Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase

Cat. No.: CASP10-597H
Description: Caspase-10 (also known as Mch4 and Flice2) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-10 exists in cells as an inactive proenzyme. During apoptosis, procaspase-10 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed form of caspase-10 consists of large (18kDa) and small (11kDa) subunits which associate to form the active enzyme.
Sourse/Host: E. coli.
Formulation: Lyophilized.
Reconstitution: Reconstitute to 1U/µl with PBS containing 15% glycerol.
Specific Activity: ~8"000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate IETD-pNA per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
Purity: ≥90% (SDS-PAGE).
Storage: For long term storage, -80°C.
Pathways: Apoptosis; RIG-I-like receptor signaling pathway; Apoptosis
Gene Name: CASP10 caspase 10, apoptosis-related cysteine peptidase [ Homo sapiens ]
Synonyms: caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; CASP10; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; EC 3.4.22.63; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Apoptotic protease Mch-4; Fas-associated death domain protein
Gene ID: 843
mRNA Refseq: NM_001230
Protein Refseq: NP_001221
MIM: 601762
UniProt ID: Q92851
Chromosome Location: 2q33-q34
Function: cysteine-type endopeptidase activity; identical protein binding; peptidase activity; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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