"CASP10" Related Products

Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase

Cat. No. : CASP10-597H
Description : Caspase-10 (also known as Mch4 and Flice2) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-10 exists in cells as an inactive proenzyme. During apoptosis, procaspase-10 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed form of caspase-10 consists of large (18kDa) and small (11kDa) subunits which associate to form the active enzyme.
Sourse/Host : E. coli.
Formulation : Lyophilized.
Reconstitution : Reconstitute to 1U/µl with PBS containing 15% glycerol.
Specific Activity : ~8"000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate IETD-pNA per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
Purity : ≥90% (SDS-PAGE).
Storage : For long term storage, -80°C.
Pathways : Apoptosis; RIG-I-like receptor signaling pathway; Apoptosis
Gene Name : CASP10 caspase 10, apoptosis-related cysteine peptidase [ Homo sapiens ]
Synonyms : caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; CASP10; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; EC; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Apoptotic protease Mch-4; Fas-associated death domain protein
Gene ID : 843
mRNA Refseq : NM_001230
Protein Refseq : NP_001221
MIM : 601762
UniProt ID : Q92851
Chromosome Location : 2q33-q34
Function : cysteine-type endopeptidase activity; identical protein binding; peptidase activity; protein binding

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