Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase
Cat.No. : | CASP10-597H |
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- Gene Information
- Related Products
Cat. No. : | CASP10-597H |
Description : | Caspase-10 (also known as Mch4 and Flice2) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-10 exists in cells as an inactive proenzyme. During apoptosis, procaspase-10 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed form of caspase-10 consists of large (18kDa) and small (11kDa) subunits which associate to form the active enzyme. |
Sourse/Host : | E. coli. |
Formulation : | Lyophilized. |
Reconstitution : | Reconstitute to 1U/µl with PBS containing 15% glycerol. |
Specific Activity : | ~8"000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate IETD-pNA per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT. |
Purity : | ≥90% (SDS-PAGE). |
Storage : | For long term storage, -80°C. |
Pathways : | Apoptosis; RIG-I-like receptor signaling pathway; Apoptosis |
Gene Name : | CASP10 caspase 10, apoptosis-related cysteine peptidase [ Homo sapiens ] |
Synonyms : | caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; CASP10; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; EC 3.4.22.63; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Apoptotic protease Mch-4; Fas-associated death domain protein |
Gene ID : | 843 |
mRNA Refseq : | NM_001230 |
Protein Refseq : | NP_001221 |
MIM : | 601762 |
UniProt ID : | Q92851 |
Chromosome Location : | 2q33-q34 |
Function : | cysteine-type endopeptidase activity; identical protein binding; peptidase activity; protein binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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