Recombinant Human ATP6V1G1, His-tagged

• Cat.No.: ATP6V1G1-846H
• Product Overview: Recombinant Human ATP6V1G1 was produced in E.coli with a His tag at N-terminus. MW = 13626Da (1-118aa).

Specification

• Cat. No.: ATP6V1G1-846H
• Description: V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.
• Source: E.coli.
• Form: 10 mM Tris. pH 8.0. 0.002% NaN3. 3mM NaCl. 2.5mM Imidazole.
• Purity: 95%.
• Clonality: N/A.
• Applications: MS. SDS.

Gene Information

• Gene Name: ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 [ Homo sapiens ]
• Synonyms: ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1; ATP6G; ATP6J; Vma10; ATP6G1; ATP6GL; DKFZp547P234; V-type proton ATPase subunit G 1; V-ATPase subunit G 1; V-ATPase 13 kDa subunit 1; vacuolar H(+)-ATPase subunit G 1; vacuolar proton pump subunit G 1; vacuolar proton pump subunit M16; vacuolar ATP synthase subunit M16; ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J; EC 3.6.3.14; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1
• Gene ID: 9550
• mRNA Refseq: NM_004888
• Protein Refseq: NP_004879
• MIM: 607296
• UniProt ID: O75348
• Chromosome Location: 9q32
• Pathway: Collecting duct acid secretion; Epithelial cell signaling in Helicobacter pylori infection; Metabolic pathways; Oxidative phosphorylation; Phagosome; Vibrio cholerae infection
• Function: ATPase activity; ATPase binding; hydrogen-exporting ATPase activity, phosphorylative mechanism; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; protein binding