Cat.No. :	TGM2-628H
Product Overview :	Recombinant Human TGM2 (Ala2-Ala687) fused with an N-terminal Met and 6-His tag, was expressed in Sf 21(baculovirus).
Description :	Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Source :	Sf 21(baculovirus)
Species :	Human
Tag :	His
Form :	Supplied as a 0.2 µm filtered solution in Tris, NaCl, Glycerol and DTT.
Bio-activity :	Measured by its ability to cleave a synthetic peptide Benzyloxycarbonyl-Gln-Gly and NH2OH. The specific activity is >1000 pmol/min/ug
Molecular Mass :	78 kDa
Endotoxin :	< 1.0 EU per 1 μg of the protein by the LAL method.
Purity :	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage :	Avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.

Gene Name :	TGM2 transglutaminase 2 [ Homo sapiens (human) ]
Official Symbol :	TGM2
Synonyms :	TGM2; TG2; TGC; GNAH; G-ALPHA-h; transglutaminase 2; protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; protein-glutamine-gamma-glutamyltransferase; C polypeptide, protein-glutamine-gamma-glutamyltransferase; EC 2.3.2.13
Gene ID :	7052
mRNA Refseq :	NM_004613
Protein Refseq :	NP_004604
MIM :	190196
UniProt ID :	P21980
Chromosome Location :	20q12
Pathway :	Huntington''s disease; Thromboxane A2 receptor signaling
Function :	GTP binding; metal ion binding; protein domain specific binding

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