KEAP1-Nrf2 Inhibitor Screening Assay Kit

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KEAP1-Nrf2 Inhibitor Screening Assay Kit

KEAP1-Nrf2 Related Products

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Cat.No. : Kit-1778
Product Overview : The nuclear factor erythroid 2-related factor (Nrf2) is a transcription factor that induces the expression of antioxidant and phase II proteins by binding to the ARE (antioxidant response element) region of the gene promoter. Under basal conditions, Nrf2 is retained in the cytosol by binding to the cytoskeletal protein Keap1. Upon exposure to oxidative stress and other ARE activators, Nrf2 is released from Keap1. It then translocates to the nucleus, where it can bind to the ARE and activate expression of antioxidant and phase II proteins that protect the cell from oxidative damage. Because Nrf2 activation leads to a coordinated antioxidant and antiinflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.
Size : 96 reactions
Applications : Great for screening small molecular inhibitors for drug discovery and HTS applications.
Storage : At least 6 months from date of receipt when stored as directed.

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