Notch1/CSL Reporter Kit (Notch Signaling Pathway)
| Cat.No. : | Kit-1786 |
| Product Overview : | The Notch signaling pathway controls cell fate decisions in vertebrate and invertebrate tissues. Notch signaling is triggered through the binding of a transmembrane ligand, such as Delta like ligand 4 (DLL4) or jagged 1 (JAG1) to a Notch transmembrane receptor (Notch1, Notch2, Notch3, Notch4) on a neighboring cell. This results in proteolytic cleavage of the Notch receptor, releasing the constitutively active intracellular domain of Notch (NICD). NICD translocates to the nucleus and associates with transcription factors CSL (CBF1, RBPJ, Suppressor of Hairless, Lag-1) and the coactivator, Mastermind, to turn on transcription of Notch responsive genes. |
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- Specification
- Gene Information
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| Size : | 500 reactions |
| Applications : | Screen for activators or inhibitors of the Notch signaling pathway.Study effects of RNAi or gene overexpression on the activity of the Notch pathway. |
| Storage : | Stable at least 12 months from date of receipt, when stored as directed (-20°C) |
| Publication : |
The long and winding road: detecting and quantifying Notch activation in endothelial cells (2021)
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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