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Recombinant Human ADRA1A protein, His & T7-tagged

Cat.No. : ADRA1A-6778H
Product Overview : Recombinant Human ADRA1A aa. (Ser330~Val466 (Accession # P35348)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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Description : Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 19.2kDa.
Protein length : Ser330~Val466 (Accession # P35348)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 9.6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : ADRA1A adrenoceptor alpha 1A [ Homo sapiens (human) ]
Official Symbol : ADRA1A
Synonyms : ADRA1C; ADRA1L1; ALPHA1AAR; G protein coupled receptor; adrenergic, alpha-1A-, receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor; alpha-1A adrenergic receptor
Gene ID : 148
mRNA Refseq : NM_000680.3
Protein Refseq : NP_000671.2
UniProt ID : P35348

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Can variations in Adra1a genes contribute to the development of mental health conditions such as depression or anxiety? 08/14/2022

There is some evidence to suggest that variations in Adra1a genes may contribute to the development of mental health conditions such as depression or anxiety. For example, certain genetic variations in Adra1a genes have been associated with an increased risk of developing panic disorder and post-traumatic stress disorder (PTSD). However, the relationship between Adra1a genes and mental health conditions is complex and not yet fully understood. Adra1a receptors are primarily found in peripheral tissues and do not have significant effects on the central nervous system compared to other adrenergic receptors. Therefore, the mechanisms by which variations in Adra1a genes may contribute to mental health conditions are unclear and require further investigation.

Are there any drugs that specifically target Adra1a proteins? 03/16/2021

Yes, there are drugs designed to specifically target Adra1a proteins. Adra1a agonists, such as phenylephrine, are used to constrict blood vessels, while Adra1a antagonists, such as prazosin, are used to relax blood vessels. Adra1a antagonists are also used to treat certain medical conditions such as hypertension, benign prostatic hyperplasia, and Raynaud's disease. Additionally, Adra1a agonists in combination with opioids are used to treat severe pain by activating Adra1a receptors in peripheral tissues. However, it is important to note that targeting Adra1a proteins can have off-target effects and may cause side effects such as dizziness, orthostatic hypotension, and reflex tachycardia. Therefore, the use of these drugs should be carefully monitored by a healthcare professional.

How do Adra1a proteins interact with other proteins within the body? 10/08/2020

Adra1a proteins interact with other proteins within the body through a variety of mechanisms. For example, Adra1a proteins can interact with G proteins, which are involved in signal transduction pathways that regulate various physiological processes such as smooth muscle contraction and gene expression. Adra1a proteins can also interact with other proteins involved in the regulation of blood pressure and vascular tone, such as angiotensin II receptors and endothelin receptors. These interactions are complex and dynamic, and ongoing research is focused on understanding the molecular mechanisms underlying these interactions.

What medical conditions are associated with Adra1a protein mutations? 03/08/2020

Mutations in Adra1a proteins have been linked to various medical conditions such as hypertension and diabetes. For example, a single nucleotide polymorphism (SNP) in the Adra1a gene has been associated with hypertension in several populations. In addition, Adra1a proteins have been implicated in the development of insulin resistance and glucose intolerance, which are hallmark features of type 2 diabetes.

Are Adra1a proteins targeted by any drugs or medications? 05/20/2019

Yes, several drugs and medications target Adra1a proteins. For example, alpha-1 adrenergic receptor agonists such as phenylephrine and oxymetazoline bind to and activate Adra1a proteins to constrict blood vessels. Similarly, alpha-1 adrenergic receptor antagonists, such as doxazosin and prazosin, bind to Adra1a proteins to block their activity and dilate blood vessels. These drugs are used to treat various conditions such as hypertension, benign prostatic hyperplasia, and nasal congestion.

Can Adra1a proteins be targeted in cancer therapy? 04/18/2019

Although Adra1a proteins themselves are not typically considered targets for cancer therapy, they may indirectly influence cancer growth and progression. For example, Adra1a proteins are involved in regulating blood vessel growth and contraction, which are important processes for supporting the growth of tumors. Additionally, some research suggests that certain genetic variations in Adra1a genes may be associated with an increased risk of certain cancers. However, direct targeting of Adra1a proteins is not currently a primary approach for cancer therapy, and more research is needed to determine their potential role in cancer treatment.

Are there any side effects associated with drugs that target Adra1a proteins? 08/26/2018

Yes, like all drugs, drugs that target Adra1a proteins can have side effects. For example, alpha-1 adrenergic receptor agonists can cause increased blood pressure, heart rate, and vasoconstriction, while alpha-1 adrenergic receptor antagonists can cause orthostatic hypotension (low blood pressure upon standing), dizziness, and headaches. It is important for patients receiving these drugs to be monitored closely by their healthcare provider for any adverse reactions.

Are there any dietary or lifestyle factors that affect Adra1a protein expression or function? 07/15/2018

Some research suggests that dietary or lifestyle factors may influence Adra1a protein expression or function. For example, certain nutrients such as vitamin D and calcium have been shown to modulate Adra1a gene expression in certain tissues. Additionally, lifestyle factors such as physical activity and stress may affect Adra1a function by altering the release of hormones such as adrenaline and noradrenaline. However, the overall impact of these factors on Adra1a proteins is complex and not fully understood, and more research is needed to determine their specific effects.

Do Adra1a proteins have any effects on the central nervous system? 07/04/2018

Adra1a proteins are primarily found in peripheral tissues such as blood vessels, and do not have significant effects on the central nervous system (CNS) compared to other adrenergic receptors such as Adra1b. However, some research suggests that Adra1a receptors may have minor effects on CNS function, such as regulating the release of neurotransmitters. For example, studies have shown that Adra1a receptors are expressed in certain brain regions and are involved in modulating dopamine release. However, the overall role of Adra1a receptors in CNS function is not fully understood, and more research is needed to determine their specific effects on neurological processes.

Can Adra1a proteins be used in diagnostic testing or biomarkers for certain medical conditions? 05/06/2017

There is ongoing research into the potential of Adra1a proteins as diagnostic markers for certain medical conditions. For example, one study found that levels of Adra1a protein were elevated in the serum of patients with hepatocellular carcinoma (liver cancer), suggesting that it may be a potential biomarker for this disease. However, more research is needed to confirm these findings and determine the potential utility of Adra1a proteins as diagnostic markers.

Are there any upcoming developments or research areas related to Adra1a proteins? 08/16/2016

Yes, ongoing research is investigating the potential role of Adra1a proteins in various medical conditions, such as heart failure and ischemia-reperfusion injury. In addition, new drugs are being developed that target Adra1a proteins with greater specificity and fewer side effects. Another area of research is investigating the role of Adra1a proteins in cancer, as recent studies suggest that these proteins may play a role in tumor growth and immune evasion.

Are there any clinical trials currently investigating the use of drugs targeting Adra1a proteins? 02/07/2016

Yes, there are currently several clinical trials underway investigating the use of drugs targeting Adra1a proteins for various medical conditions. For example, one clinical trial is investigating the use of an Adra1a antagonist for the treatment of postoperative ileus (a condition that can occur after abdominal surgery). Another clinical trial is investigating the use of an Adra1a antagonist for the treatment of heart failure with preserved ejection fraction (a type of heart failure that is associated with diastolic dysfunction). These trials are still ongoing, and more research is needed to determine the safety and efficacy of these drugs.

Customer Reviews (4)

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Reviews
09/24/2021

    With the right product and support, researchers can confidently plan and execute their experiments, ultimately contributing to advancing our understanding of ADPRM protein and its role in disease.

    06/21/2019

      I believe that investing in a high-quality ADPRM protein and utilizing the excellent technical support provided by the manufacturer will enable researchers to conduct informative experiments and uncover valuable insights.

      08/11/2018

        the combination of high-quality ADPRM protein and excellent technical support from the manufacturer can enable researchers to successfully carry out their experiments and advance scientific knowledge in this field.

        05/21/2018

          It's reassuring to know that the manufacturer provides information on the purity of their products and conduct rigorous quality control measures to maintain consistency and accuracy.

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