Recombinant Human IL28A

• Cat.No.: IL28A-29785TH
• Product Overview: Recombinant Human IL28A, a 19.6 kDa protein containing 174 amino acid residues.

Specification

• Description: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
• Source: E. coli
• Biological activity: Biological activity of IL28A-29785TH is determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells.
• Form: Lyophilised
• Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
• Sequences of amino acids: PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV
• Sequence Similarities: Belongs to the IL-28/IL-29 family.
• Tag: Non

Gene Information

• Gene Name: IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens ]
• Official Symbol: IL28A
• Synonyms: IL28A; interleukin 28A (interferon, lambda 2); interleukin 28A; interleukin-28A; IFNL2; IL 28A
• Gene ID: 282616
• mRNA Refseq: NM_172138
• Protein Refseq: NP_742150
• MIM: 607401
• Uniprot ID: Q8IZJ0
• Chromosome Location: 19q13.13
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine activity

Reviews

11/15/2022

No need to prepare a special environment, storage conditions are very simple, can be stored for a long time.

10/04/2020

Very stable, strong anti-pollution ability, the experimental results are very good.

07/16/2019

The labeling effect is very good, and fluorescent labeling can be carried out.

Q&As

What is the main mechanism of action of IL28A?

It can enhance the body's immunity to pathogens by activating the immune system.

What is the role IL28A on the immune system?

IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.

What are the pharmacokinetic characteristics of IL28A?

It has a long half-life and low clearance, which can maintain a stable plasma concentration.

How's the progress of clinical trials of IL28A?

IL28A is undergoing several clinical trials and is currently showing some efficacy.

How the synthesis and purification method of IL28A?

This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.

What are the application prospects of IL28A in tumor therapy?

IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.