Recombinant Human IL28A
|Product Overview :||Recombinant Human IL28A, a 19.6 kDa protein containing 174 amino acid residues.|
- Gene Information
- Related Products
|Description :||This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).|
|Source :||E. coli|
|Biological activity :||Biological activity of IL28A-29785TH is determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells.|
|Storage :||The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.|
|Sequences of amino acids :||PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV|
|Sequence Similarities :||Belongs to the IL-28/IL-29 family.|
|Gene Name :||IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens ]|
|Official Symbol :||IL28A|
|Synonyms :||IL28A; interleukin 28A (interferon, lambda 2); interleukin 28A; interleukin-28A; IFNL2; IL 28A;|
|Gene ID :||282616|
|mRNA Refseq :||NM_172138|
|Protein Refseq :||NP_742150|
|Uniprot ID :||Q8IZJ0|
|Chromosome Location :||19q13.13|
|Pathway :||Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;|
|Function :||cytokine activity;|
|IL28A-5229HCL||Recombinant Human IL28A 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It can enhance the body's immunity to pathogens by activating the immune system.
IL28A regulates the activity and differentiation of immune cells and enhances the function of the immune system.
It has a long half-life and low clearance, which can maintain a stable plasma concentration.
IL28A is undergoing several clinical trials and is currently showing some efficacy.
This protein is usually synthesized using recombinant DNA technology and purified by column chromatography and other methods.
IL28A can regulate immune response and enhance anti-tumor immunity in tumor therapy.
Customer Reviews (3)Write a review
Use cell experiments to verify the regulatory effects on cell signal transduction pathways, such as immune response, inflammation, etc. -
Its molecular weight and composition were determined by western blotting and mass spectrometry, and its biological activity against specific cell lines, such as antiviral effect, was tested. -
Its stability at different temperatures and pH conditions needs to be tested to determine its performance during storage and use. -
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