Recombinant Human IMPDH2 Protein, His-tagged IMPDH2-01H

Recombinant Human IMPDH2 Protein, His-tagged

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Recombinant Human IMPDH2 Protein, His-tagged

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Cat.No. : IMPDH2-01H
Product Overview : Recombinant human IMP Dehydrogenase 2/IMPDH2 protein Met1-Phe514, with a C-terminal 10-His tag was expressed in Spodoptera frugiperda, Sf 21 (baculovirus).
Description : This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Source : Insects Cell
Species : Human
Tag : His
Bio-activity : Measured by its ability to convert the substrate inosine-5'-phosphate (IMP) to xanthosine-5'-phosphate (XMP). The specific activity is >30 pmol/min/μg.
Molecular Mass : 57 kDa
N-terminal Sequence Analysis : Met1 predicted
Endotoxin : <0.10 EU per 1 μg of the protein by the LAL method.
Purity : > 90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Storage Buffer : Supplied as a 0.2 μm filtered solution in Tris, NaCl, DTT and Glycerol.
Shipping : The product is shipped with dry ice or equivalent.
SDS-PAGE :

1 μg/lane of Recombinant Human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silverstaining, showing a band at 57 kDa.

Gene Name : IMPDH2 inosine monophosphate dehydrogenase 2 [ Homo sapiens (human) ]
Official Symbol : IMPDH2
Synonyms : IMPDH2; inosine monophosphate dehydrogenase 2; IMPD2; IMPDH-II; inosine-5'-monophosphate dehydrogenase 2; IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPDH 2; epididymis secretory sperm binding protein; inosine 5' phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; EC 1.1.1.205
Gene ID : 3615
mRNA Refseq : NM_000884
Protein Refseq : NP_000875
MIM : 146691
UniProt ID : P12268

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