Recombinant Human IMPDH2 Protein, His-tagged
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|Product Overview :||Recombinant human IMP Dehydrogenase 2/IMPDH2 protein Met1-Phe514, with a C-terminal 10-His tag was expressed in Spodoptera frugiperda, Sf 21 (baculovirus).|
|Description :||This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.|
|Source :||Insects Cell|
|Bio-activity :||Measured by its ability to convert the substrate inosine-5'-phosphate (IMP) to xanthosine-5'-phosphate (XMP). The specific activity is >30 pmol/min/μg.|
|Molecular Mass :||57 kDa|
|N-terminal Sequence Analysis :||Met1 predicted|
|Endotoxin :||<0.10 EU per 1 μg of the protein by the LAL method.|
|Purity :||> 90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.|
|Storage :||Avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
|Storage Buffer :||Supplied as a 0.2 μm filtered solution in Tris, NaCl, DTT and Glycerol.|
|Shipping :||The product is shipped with dry ice or equivalent.|
1 μg/lane of Recombinant Human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silverstaining, showing a band at 57 kDa.
|Gene Name :||IMPDH2 inosine monophosphate dehydrogenase 2 [ Homo sapiens (human) ]|
|Official Symbol :||IMPDH2|
|Synonyms :||IMPDH2; inosine monophosphate dehydrogenase 2; IMPD2; IMPDH-II; inosine-5'-monophosphate dehydrogenase 2; IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPDH 2; epididymis secretory sperm binding protein; inosine 5' phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; EC 22.214.171.124|
|Gene ID :||3615|
|mRNA Refseq :||NM_000884|
|Protein Refseq :||NP_000875|
|UniProt ID :||P12268|
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