Recombinant Human NFE2L2 Protein, MYC/DDK-tagged KCNQ4-22H

Cat.No. :	KCNQ4-22H
Product Overview :	Recombinant protein of human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2 with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description :	The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
Source :	HEK293T
Species :	Human
Tag :	MYC/DDK
Molecular Mass :	71 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Storage :	Store at –80 centigrade. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Concentration :	>50 μg/mL as determined by microplate BCA method.
Storage Buffer :	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

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Gene Name :	KCNQ4 potassium voltage-gated channel subfamily Q member 4 [ Homo sapiens (human) ]
Official Symbol :	KCNQ4
Synonyms :	KCNQ4; potassium voltage-gated channel subfamily Q member 4; DFNA2; KV7.4; DFNA2A;
Gene ID :	9132
mRNA Refseq :	NM_172163
Protein Refseq :	NP_751895
MIM :	603537
UniProt ID :	P56696