| Description : |
Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
108.5 kDa |
| AA Sequence : |
MKTETVPPFQETPAGSSCHLNNLLS SRKLMAVGVLLGWLLVIHLLVNVWL LCLLSALLVVLGGWLGSSLAGVASG RLHLERFIPLATCPPCPEAERQLER EINRTIQMIIRDFVLSWYRSVSQEP AFEEEMEAAMKGLVQELRRRMSVMD SHAVAQSVLTLCGCHLQSYIQAKEA TAGKNGPVEPSHLWEAYCRATAPHP AVHSPSAEVTYTRGVVNLLLQGLVP KPHLETRTGRHVVVELITCNVILPL ISRLSDPDWIHLVLVGIFSKARDPA PCPASAPEQPSVPTSLPLIAEVEQL PEGRASPVAAPVFLSYSEPEGSAGP SPEVEEGHEAVEGDLGGMCEERKVG NNSSHFLQPNVRGPLFLCEDSELES PLSELGKETIMLMTPGSFLSDRIQD ALCALESSQALEPKDGEASEGAEAE EGPGTETETGLPVSTLNSCPEIHID TADKEIEQGDVTASVTALLEGPEKT CPSRPSCLEKDLTNDVSSLDPTLPP VLLSSSPPGPLSSATFSFEPLSSPD GPVIIQNLRITGTITAREHSGTGFH PYTLYTVKYETALDGENSSGLQQLA YHTVNRRYREFLNLQTRLEEKPDLR KFIKNVKGPKKLFPDLPFGNMDSDR VEARKSLLESFLKQLCAIPEIANSE EVQEFLALNTDARIAFVKKPFMVSR IDKMVVSAIVDTLKTAFPRSEPQSP TEELSEAETESKPQTEGKKASKSRL RFSSSKISPALSVTEAQDKILYCLQ EGNVESETLSMSAMESFIEKQTKLL EMQPTKAPEKDPEQPPKGRVDSCVS DAAVPAQDPSNSDPGTETELADTAL DLLLLLLTEQWKWLCTENMQKFLRL IFGTLVQRWLEVQVANLTSPQRWVQ YLLLLQESIWPGGVLPKFPRPVRTQ EQKLAAEKQALQSLMGVLPDLVVEI LGVNKCRLSWGLVLESLQQPLINRH LIYCLGDIILEFLDLSASVEESAAT TSASDTPGNSKRMGVSSSGPSGPTR TRRLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
