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Recombinant Mouse Aldoc Protein, MYC/DDK-tagged

Cat.No. : Aldoc-575M
Product Overview : Purified recombinant protein of full-length mouse aldolase C, fructose-bisphosphate (Aldoc), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : This gene encodes a member of the aldolase family of enzymes that is mainly expressed in neuronal tissues. The encoded protein is an enzyme of the glycolysis pathway, and catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Alternate splicing of this gene results in multiple transcript variants.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 39.3 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Aldoc aldolase C, fructose-bisphosphate [ Mus musculus (house mouse) ]
Official Symbol : Aldoc
Synonyms : Aldoc; aldolase C, fructose-bisphosphate; Aldo3; Scrg2; AI847350; AU040929; fructose-bisphosphate aldolase C; aldolase 3, C isoform; brain-type aldolase; scrapie responsive gene 2; scrapie-responsive protein 2; zebrin II; EC 4.1.2.13
Gene ID : 11676
mRNA Refseq : NM_009657
Protein Refseq : NP_033787
UniProt ID : P05063

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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Can ALDOC expression or activity be influenced by environmental factors? 05/14/2022

Yes, ALDOC expression or activity can be influenced by various environmental factors. For example, changes in glucose availability and insulin signaling can modulate ALDOC expression. Additionally, oxygen levels, pH, and cellular stress can impact ALDOC activity. Environmental factors such as diet, exercise, and exposure to toxins or drugs can also affect ALDOC expression and function. These factors can potentially have implications for metabolic disorders and neurological conditions.

Are there any known drugs or compounds that can modulate ALDOC expression or activity? 12/06/2021

Currently, there are no specific drugs or compounds approved for the direct modulation of ALDOC expression or activity. However, certain compounds like dimethyl sulfoxide (DMSO) and valproic acid have been shown to increase ALDOC expression in certain cellular models. Additionally, some agents targeting glucose metabolism and glycolysis pathways might indirectly affect ALDOC activity. Nonetheless, further research is needed to identify more specific drug targets and develop therapeutic strategies involving ALDOC modulation.

Is the ALDOC protein involved in any diseases other than aldolase C deficiency and brain tumors? 09/23/2021

While aldolase C deficiency and brain tumors are the primary conditions associated with ALDOC mutations, there is emerging evidence linking the protein to other diseases and pathological processes. Studies have suggested potential roles of ALDOC in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. However, further research is needed to fully understand the implications of ALDOC in these contexts.

Are there any other conditions associated with mutations in the ALDOC gene? 12/23/2020

In addition to aldolase C deficiency, mutations in the ALDOC gene have been implicated in other conditions, such as brain tumors. Research suggests that alterations in ALDOC expression and activity may play a role in tumor development and progression.

How does the ALDOC protein contribute to brain development and function? 08/19/2020

The ALDOC protein plays a crucial role in brain development and function by participating in glucose metabolism and energy production. It is highly expressed in neurons and astrocytes, where it facilitates the production of ATP through glycolysis. This energy is necessary for various cellular processes, including neuronal signaling, synaptic transmission, and overall brain function. ALDOC deficiency or dysfunction can disrupt energy metabolism in the brain and have detrimental effects on brain development and function.

Are there any drugs or therapies targeting the ALDOC protein? 03/22/2020

Currently, there are no specific drugs or therapies targeting the ALDOC protein. However, ongoing research into the biochemical and functional aspects of ALDOC may uncover new potential therapeutic strategies. For example, targeting the glycolytic pathway or modulating ALDOC expression could be areas of investigation in the future.

What happens if there are mutations in the ALDOC gene? 02/23/2020

Mutations in the ALDOC gene can lead to a condition called aldolase C deficiency. This rare condition can cause a range of neurological symptoms, including motor dysfunction, cognitive impairment, and seizures.

How is the ALDOC protein regulated in cells? 12/17/2019

The regulation of ALDOC protein expression and activity can be affected by various factors, including cellular signaling pathways, transcription factors, and post-translational modifications. For example, glucose levels and insulin signaling can influence ALDOC expression. Additionally, phosphorylation and glycosylation events can modify the activity of the protein.

Can ALDOC be targeted for therapeutic interventions in neurological disorders? 03/10/2019

Targeting ALDOC for therapeutic interventions in neurological disorders is an area of ongoing research. Modulating ALDOC expression or activity may offer potential therapeutic benefits. For example, increasing ALDOC expression or activity could enhance energy metabolism and protect against neurodegeneration in conditions like Alzheimer's or Parkinson's disease.

Can ALDOC protein levels or activity be used as a biomarker for any diseases? 02/07/2019

There is ongoing research into the potential use of ALDOC as a biomarker for certain diseases. For example, altered ALDOC expression has been observed in brain tumors and could potentially serve as a diagnostic or prognostic marker. However, more studies are needed to validate its clinical utility and determine its reliability as a biomarker.

Can mutations in the ALDOC gene be inherited? 01/29/2019

Yes, mutations in the ALDOC gene can be inherited. Aldolase C deficiency, caused by ALDOC mutations, follows an autosomal recessive pattern of inheritance. This means that an affected individual must inherit two copies of the mutated gene (one from each parent) in order to exhibit symptoms of the disorder. If both parents carry a single copy of the mutated ALDOC gene, they have a 25% chance of having an affected child with aldolase C deficiency.

Is the ALDOC protein involved in any non-brain-related physiological processes? 01/14/2019

While the ALDOC protein is most well-known for its role in brain metabolism, it is also found in other tissues and organs. In non-brain tissues, ALDOC participates in the glycolytic pathway and contributes to energy production. However, the specific physiological functions of ALDOC in non-brain tissues are not as extensively studied as those in the brain.

Can prenatal testing detect aldolase C deficiency? 10/24/2018

Yes, prenatal testing is available for aldolase C deficiency. It involves analyzing fetal DNA obtained through procedures like chorionic villus sampling (CVS) or amniocentesis to identify mutations in the ALDOC gene. This allows for early detection of the condition, aiding in family planning and preparation for managing the condition after birth.

Are there any genetic disorders associated with mutations in the ALDOC gene? 01/05/2018

Yes, mutations in the ALDOC gene can cause a rare genetic disorder called aldolase C deficiency. This disorder is characterized by a lack or reduced activity of the ALDOC enzyme, leading to impaired glycolysis in the brain. Aldolase C deficiency can result in developmental delays, intellectual disability, abnormal muscle tone, and movement disorders

Are there any ongoing clinical trials investigating the role of ALDOC in neurological disorders? 07/18/2017

As of the latest information, there are no ongoing clinical trials specifically investigating the role of ALDOC in neurological disorders. However, research on ALDOC and its potential implications in various neurological conditions is an active area of study. It is possible that future clinical trials may emerge to explore the therapeutic potential of modulating ALDOC in specific neurological disorders.

How are mutations in the ALDOC gene detected? 06/19/2017

Mutations in the ALDOC gene can be detected through genetic testing methods. DNA sequencing techniques can identify specific changes or variations in the DNA sequence of the gene, allowing for the diagnosis of aldolase C deficiency or other related conditions.

Is there a treatment for aldolase C deficiency? 09/27/2016

Currently, there is no specific treatment for aldolase C deficiency. Management typically focuses on supportive care and symptom relief. Physiotherapy, speech therapy, and occupational therapy may be employed to address the neurological symptoms associated with the condition.

Are there any ongoing studies or research related to the ALDOC protein? 08/23/2016

Yes, there are ongoing studies and research related to the ALDOC protein. Scientists are aiming to further elucidate the role of ALDOC in brain development, neurological disorders, and tumor biology. Additionally, efforts are being made to understand the regulatory mechanisms involved in ALDOC expression and activity.

Can altered ALDOC expression or activity contribute to neurological disorders? 07/13/2016

There is emerging evidence suggesting that altered ALDOC expression or activity may contribute to the development and progression of neurological disorders. For example, decreased ALDOC expression has been associated with Alzheimer's disease and Parkinson's disease. Additionally, changes in ALDOC expression have been observed in epilepsy, schizophrenia, and traumatic brain injury. However, the exact mechanisms by which ALDOC alterations contribute to these disorders are still not fully understood and require further investigation.

Is aldolase C deficiency a hereditary condition? 05/05/2016

Yes, aldolase C deficiency is an inherited disorder. It follows an autosomal recessive inheritance pattern, which means that an affected individual needs to inherit two copies of the mutated ALDOC gene (one from each parent) to develop the condition.

How is ALDOC expression regulated in the brain? 01/24/2016

The exact mechanisms regulating ALDOC expression in the brain are not fully understood. However, several factors and signaling pathways have been implicated in its regulation. Glucose availability and insulin signaling can influence ALDOC expression, with high glucose levels and insulin promoting its expression.

Customer Reviews (4)

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Reviews
04/11/2022

    The ALDOC Protein consistently produces well-defined and interpretable structural data, enabling me to unravel complex macromolecular assemblies and their mechanisms.

    12/14/2021

      It reliably and accurately detects and quantifies target molecules, allowing for precise measurement of analytes in my samples.

      07/04/2020

        The sensitivity and specificity of the ALDOC Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.

        12/14/2016

          I highly recommend the ALDOC Protein for its outstanding performance in ELISA assays.

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