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Recombinant Mouse Arcn1 Protein, Myc/DDK-tagged

Cat.No. : Arcn1-1673M
Product Overview : Purified recombinant protein of mouse full-length archain 1 (Arcn1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 57.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Arcn1 archain 1 [ Mus musculus (house mouse) ]
Official Symbol : Arcn1
Synonyms : ARCN1; archain 1; coatomer subunit delta; delta-COP; pale coat neuro; delta-coat protein; nur17; 4632432M07Rik; MGC27546; MGC102316
Gene ID : 213827
mRNA Refseq : NM_145985
Protein Refseq : NP_666097
UniProt ID : Q5XJY5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Has any research been done on potential targeted therapies for SIDSPP caused by ARCN1 mutations? 10/01/2022

As the understanding of ARCN1-related disorders is relatively recent, there is limited research on targeted therapies. However, ongoing studies are exploring potential approaches such as gene therapy or pharmacological interventions to address the underlying cellular defects.

Are there any drugs or compounds known to modulate ARCN1 activity? 03/07/2022

Currently, there are no specific drugs or compounds known to directly modulate ARCN1 activity. However, there are efforts to develop small molecules that target vesicle trafficking pathways, which indirectly affect ARCN1 function.

Are there any known interactions or partners of the ARCN1 protein? 02/04/2022

Yes, the ARCN1 protein interacts with various other proteins in the coatomer complex, such as COPB1, COPB2, and CNIH4, to form stable complexes involved in vesicle trafficking.

Can the ARCN1 protein serve as a therapeutic target for any diseases? 02/02/2022

Given its key role in vesicle transport and potential involvement in certain diseases, targeting the ARCN1 protein or its associated complexes could hold therapeutic potential. However, more research is required to explore the feasibility and efficacy of such targeted therapies.

How does the mutation in the ARCN1 gene lead to SIDSPP? 12/07/2021

The specific mechanisms by which ARCN1 gene mutations lead to SIDSPP are not yet fully understood. However, it is hypothesized that these mutations disrupt normal vesicle transport within neuronal cells, leading to impaired development and function of the central nervous system.

Are there any specific domains or motifs in the ARCN1 protein that are crucial for its function? 11/15/2021

ARCN1 contains multiple domains that are important for its function in vesicle trafficking, such as the β-propeller and α-solenoid domains. These domains mediate interactions with other proteins and vesicle coat components, allowing ARCN1 to be involved in the formation and regulation of COPI-coated vesicles.

How does the ARCN1 protein contribute to normal neuronal development and function? 10/20/2020

ARCN1 is involved in the proper sorting and transport of various proteins, lipids, and other cellular components within neurons. This process is crucial for neuronal development, synaptic function, and overall neuronal communication.

Is ARCN1 expression regulated by any specific transcription factors or signaling pathways? 07/15/2020

The specific transcription factors or signaling pathways that regulate ARCN1 expression have not been extensively studied. Further research is needed to identify the regulatory elements and mechanisms governing ARCN1 gene expression.

Are there any animal models that have been developed to study the function of ARCN1? 07/05/2019

Yes, animal models like mice with ARCN1 gene knockout or specific mutations have been generated to investigate the effects of ARCN1 dysfunction on development and behavior.

Has ARCN1 been implicated in neurodevelopmental disorders other than Severe Intellectual Disability with Progressive Spastic Paraplegia? 04/24/2019

To date, ARCN1 alterations have primarily been associated with Severe Intellectual Disability with Progressive Spastic Paraplegia. However, further research is needed to explore its potential involvement in other neurodevelopmental disorders.

What are the symptoms of Severe Intellectual Disability with Progressive Spastic Paraplegia (SIDSPP)? 04/10/2019

Individuals with SIDSPP typically experience severe intellectual disability, impaired motor skills, and progressive spastic paraplegia, characterized by stiffness and weakness in the lower extremities.

Is the ARCN1 protein involved in any other cellular processes apart from vesicle transport? 12/23/2018

Yes, the ARCN1 protein has been reported to have additional functions, including its involvement in protein glycosylation, membrane traffic regulation, and ER-Golgi transport.

Can mutations or dysregulation of the ARCN1 gene lead to other phenotypic features or conditions? 07/29/2018

While ARCN1 alterations have been mostly associated with Severe Intellectual Disability with Progressive Spastic Paraplegia, it is possible that they may contribute to a broader spectrum of phenotypic features and conditions. This could include changes in neuronal morphology, synaptic function, or other cellular processes affected by ARCN1 dysfunction.

Are there any specific cellular pathways or processes that ARCN1 is known to be involved in? 03/15/2018

ARCN1 is primarily involved in intracellular vesicle trafficking, particularly in the formation and maintenance of coat protein complex I (COPI) vesicles. COPI-mediated vesicular transport is essential for protein and lipid sorting, maintenance of organelle integrity, and intra-Golgi and retrograde Golgi-to-ER transport.

Are mutations in the ARCN1 gene associated with any diseases? 01/27/2018

Yes, mutations in the ARCN1 gene have been linked to a rare neurodevelopmental disorder known as Severe Intellectual Disability with Progressive Spastic Paraplegia (SIDSPP).

Is there any evidence of ARCN1 protein playing a role in synaptic transmission? 10/05/2017

While the exact role of ARCN1 in synaptic transmission is not fully understood, studies have suggested its involvement in regulating the release of neurotransmitters and the recycling of synaptic vesicles, which are essential processes for effective synaptic transmission.

Are there any known alternative splicing variants or isoforms of the ARCN1 gene? 09/23/2017

Yes, alternative splicing of the ARCN1 gene can generate multiple isoforms. However, the functional significance of these isoforms and their specific roles in different tissues or conditions is still not well characterized.

Has the ARCN1 protein been implicated in any other diseases or conditions? 03/24/2017

Apart from its association with Severe Intellectual Disability with Progressive Spastic Paraplegia, ARCN1 alterations have not been extensively linked to other diseases. However, some studies have suggested potential involvement of ARCN1 in cancer progression and neurodegenerative disorders, although further research is needed to establish these connections.

Are there any known post-translational modifications of the ARCN1 protein? 02/10/2017

While there is limited information available regarding post-translational modifications of ARCN1, it has been suggested that ARCN1 may undergo phosphorylation, acetylation, and ubiquitination, which may regulate its function and stability.

How does the ARCN1 protein contribute to vesicle transport? 01/09/2017

ARCN1, as part of the coatomer complex, helps in the formation of coat protein complex I (COPI) vesicles, which mediate retrograde transport from the Golgi to the endoplasmic reticulum and also within the Golgi itself.

Customer Reviews (8)

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Reviews
01/10/2023

    the manufacturer can play a vital role in supporting and optimizing the research process.

    12/02/2021

      ts stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.

      09/16/2021

        This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.

        09/01/2021

          I am delighted to highly recommend the ARCN1 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis

          04/26/2020

            This may include providing detailed protocols, troubleshooting advice, and suggestions for experimental design.

            01/21/2020

              In WB experiments, the ARCN1 Protein consistently delivers exceptional performance.

              06/24/2017

                Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.

                10/06/2016

                  The manufacturer can offer technical support and expertise to guide researchers through the experimental process.

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