Recombinant Mouse Chemokine (C-X-C motif) ligand 1, His-tagged

Cat.No. : Cxcl1-377M
Product Overview : Recombinant mouse Cxcl1protein, fused to His-tag at N-terminus, was expressed in E.coli and purifiedby using conventional chromatography techniques
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Cat. No. : Cxcl1-377M
Description : Cxcl1, also known asGROA or GRO-alpha, is a growth factor for melanoma cells and a chemotaxin forneutrophils. Similar to other alpha chemokines, this protein is potentneutrophil attractant and activator and is also active toward basophils. Inaddition, Cxcl1 protein may be a therapeutic target as well as a diagnosticmarker in ovarian cancer.
Source : E. coli
Species : Mouse
Form : Liquid. 20mMTris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl.
Molecular Weight : 10.5 kDa(97aa), confirmedby MALDI-TOF.
Purity : > 90% by SDS -PAGE.
Concentration : 0.5mg/ml (determinedby Bradford assay).
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MGSHMAPIAN ELRCQCLQTM AGIHLKNIQS LKVLPSGPHC TQTEVIATLK NGREACLDPEAPLVQKIVQK MLKGVPK
Storage : Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol : Cxcl1
Gene Name : Cxcl1 chemokine (C-X-C motif)ligand 1 [ Mus musculus ]
Synonyms : Cxcl1; chemokine(C-X-C motif) ligand 1; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1;growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; secretoryprotein N51; C-X-C motif chemokine 1; platelet-derived growth; factor-inducibleprotein KC
Gene ID : 14825
mRNA Refseq : NM_008176
Protein Refseq : NP_032202
UniProt ID : P12850
Chromosome Location : 5 E-F; 5 51.0 cM
Pathway : Chemokine receptorsbind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-likereceptors); Cytokine-cytokine receptor interaction; Cytokines andInflammatory Response (BioCarta); G alpha (i) signalling events; GPCRdownstream signaling; GPCR ligand binding; Legionellosis; Legionellosis;NOD-like receptor signaling pathway; Peptide ligand-binding receptors;Salmonella infection; Signal Transduction; Signaling by GPCR
Function : chemokine activity;cytokine activity; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any therapeutic strategies targeting CXCL1? 11/17/2022

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation? 05/03/2022

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression? 09/30/2021

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis? 04/21/2021

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system? 11/15/2019

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated? 08/05/2018

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells? 02/06/2018

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.

Customer Reviews (3)

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Reviews
06/15/2020

    Efficient delivery, great service.

    01/01/2019

      Product as described, perfect.

      10/13/2018

        Reliable for protein work.

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