Recombinant Mouse Chemokine (C-X-C motif) ligand 1, His-tagged
|Product Overview :||Recombinant mouse Cxcl1protein, fused to His-tag at N-terminus, was expressed in E.coli and purifiedby using conventional chromatography techniques|
- Gene Information
- Related Products
|Cat. No. :||Cxcl1-377M|
|Description :||Cxcl1, also known asGROA or GRO-alpha, is a growth factor for melanoma cells and a chemotaxin forneutrophils. Similar to other alpha chemokines, this protein is potentneutrophil attractant and activator and is also active toward basophils. Inaddition, Cxcl1 protein may be a therapeutic target as well as a diagnosticmarker in ovarian cancer.|
|Source :||E. coli|
|Form :||Liquid. 20mMTris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl.|
|Molecular Weight :||10.5 kDa(97aa), confirmedby MALDI-TOF.|
|Purity :||> 90% by SDS -PAGE.|
|Concentration :||0.5mg/ml (determinedby Bradford assay).|
|Sequences of aminoacids :||MGSSHHHHHHSSGLVPRGSH MGSHMAPIAN ELRCQCLQTM AGIHLKNIQS LKVLPSGPHC TQTEVIATLK NGREACLDPEAPLVQKIVQK MLKGVPK|
|Storage :||Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.|
|Gene Name :||Cxcl1 chemokine (C-X-C motif)ligand 1 [ Mus musculus ]|
|Synonyms :||Cxcl1; chemokine(C-X-C motif) ligand 1; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1;growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; secretoryprotein N51; C-X-C motif chemokine 1; platelet-derived growth; factor-inducibleprotein KC|
|Gene ID :||14825|
|mRNA Refseq :||NM_008176|
|Protein Refseq :||NP_032202|
|UniProt ID :||P12850|
|Chromosome Location :||5 E-F; 5 51.0 cM|
|Pathway :||Chemokine receptorsbind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-likereceptors); Cytokine-cytokine receptor interaction; Cytokines andInflammatory Response (BioCarta); G alpha (i) signalling events; GPCRdownstream signaling; GPCR ligand binding; Legionellosis; Legionellosis;NOD-like receptor signaling pathway; Peptide ligand-binding receptors;Salmonella infection; Signal Transduction; Signaling by GPCR|
|Function :||chemokine activity;cytokine activity; growth factor activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.
It mediates inflammation by promoting leukocyte migration and activation.
In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.
CXCL1 contributes to angiogenesis, supporting new blood vessel formation.
CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.
CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.
CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.
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Efficient delivery, great service. -
Product as described, perfect. -
Reliable for protein work. -
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