"Idua" Related Products


Recombinant Mouse Idua protein, His-tagged

Cat.No.: Idua-220M
Product Overview: Recombinant Mouse Idua (Glu17-Ser634) fused with His tag at C-terminal was expressed in NS0.
Description: alpha -L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGS). It hydrolyzes the non-reducing terminal alpha -L-iduronic acid residues in GAGS including dermatan sulfate and heparan sulfate. Mature mouse IDUA shares 80% aa identity with human IDUA. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I can be classified as three clinical subtypes; Hurler syndrome, Hurler-Scheie syndrome, and Scheie syndrome with decreasing severity, respectively. MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy show positive results. Recently, the IDUA gene has been linked to osteoporosis.
Source: NS0
Species: Mouse
Tag : His
Predicted N Terminal: Glu17
Form: Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl and Glycerol.
Bio-activity: Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl alpha -L-iduronide. The specific activity is >7,500 pmol/min/ug.
Molecular Mass: Predicted Molecular Mass: 70 kDa
SDS-PAGE: 83-95 kDa, reducing conditions
Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Gene Name: Idua iduronidase, alpha-L- [ Mus musculus ]
Official Symbol: Idua
Synonyms: IDUA; iduronidase, alpha-L-; alpha-L-iduronidase; 6030426D08;
Gene ID: 15932
mRNA Refseq: NM_008325
Protein Refseq: NP_032351

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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