Recombinant Mouse Il18bp
Cat.No. : | Il18bp-8339M |
Product Overview : | Recombinant Mouse Il18bp was expressed in NSO Cells. |
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Description : | IL-18-binding protein (IL-18BP) is a secreted glycoprotein in the IL-1 family of ligands, however, it bears no amino acid sequence homology to the membrane-associated IL-18 and IL-1 receptor proteins. IL-18BP functions as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL-18 levels during inflammation. It is constitutively expressed and secreted in mononuclear cells and can be enhanced by IFN gamma, which suggests IL-18 activity is modulated by a negative feedback mechanism via IL-18BP. There are four known variants of IL-18BP (a, b, c & d). The isoform IL-18BPd, also known as MC54L, lacks a complete Ig domain and the ability to bind or neutralize IL-1. IL-18BPd has been shown to be produced as a secreted full-length molecule that binds cell surface glycosaminoglycans in the extracellular matrix and also as a furin-cleaved form that contains only the IL-18 binding domain. It is related to a secreted viral protein, vIL-18BP, and may contribute to the lack of inflammatory responses characteristic of molluscum contagiosum virus lesions. |
Source : | Mammalian cells |
Species : | Mouse |
Form : | This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. |
Molecular Mass : | The predicted molecular weight of Recombinant Mouse IL-18 BPd is Mr 44.5 kDa (monomer). However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 60-70 kDa. |
AA Sequence : | tsap qttatvltgs skdpcsswsp avptkqypal dviwpekevp lngtltlsct acsrfpyfsi lywlgngsfi ehlpgrlkeg htsrehrnts twlhralvle elsptlrstn fsclfvdpgq vaqyhiilaq lwdglktapp psqetlsshs pvsrsagpgv aiegrmdpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgk |
Endotoxin : | <1.0 eu/μg as determined by the lal>1.0> |
Purity : | >90% by SDS-PAGE and analyzed by silver stain. |
Storage : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Tag : | Non |
Gene Name : | Il18bp interleukin 18 binding protein [ Mus musculus ] |
Official Symbol : | Il18bp |
Synonyms : | IL18BP; interleukin 18 binding protein; interleukin-18-binding protein; interferon gamma inducing factor binding protein; interferon gamma-inducing factor-binding protein; MC54L; Igifbp; IL-18BP; |
Gene ID : | 16068 |
mRNA Refseq : | NM_010531 |
Protein Refseq : | NP_034661 |
Function : | interleukin-18 binding; |
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IL18BP-315H | Recombinant Human IL18BP Protein, His-tagged | +Inquiry |
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◆ Lysates | ||
IL18BP-2674MCL | Recombinant Mouse IL18BP cell lysate | +Inquiry |
IL18BP-2918HCL | Recombinant Human IL18BP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewConsistent binding affinity.
High purity.
Effective in neutralization assays.
Q&As (10)
Ask a questionGenetic association studies, sequencing analyses, and functional investigations explore how genetic variations in IL18BP might influence disease susceptibility and outcomes.
Knockout mice, transgenic models, and imaging techniques provide insights into IL18BP's impact on IL18-related immune responses in vivo.
Promoter studies, siRNA knockdown, and cytokine stimulation assays investigate IL18BP regulation at the transcriptional and post-transcriptional levels.
Luciferase reporter assays, ELISAs, and functional cell assays probe how IL18BP modulates IL18-induced cytokine production and immune cell activation.
Biophysical techniques, site-directed mutagenesis, and receptor binding assays reveal potential allosteric effects on IL18 signaling.
Surface plasmon resonance, isothermal titration calorimetry, and kinetic binding assays quantify IL18BP-IL18 interactions.
RT-qPCR, immunohistochemistry, and tissue microarray analyses determine the expression patterns of IL18BP in different tissues and diseases.
X-ray crystallography, NMR spectroscopy, and mutagenesis studies elucidate the structural basis of IL18BP-IL18 recognition.
Cross-competition assays, co-stimulation studies, and receptor activation assays unveil potential interplay between IL18BP and other cytokine regulators.
Therapeutic antibody trials, in vitro functional screens, and disease model assessments evaluate IL18BP modulation as a potential anti-inflammatory strategy.
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