alpl
Share
  • Official Full Name
  • alkaline phosphatase, liver/bone/kidney
  • Background
  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and;liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue;non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is;not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.;The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the;enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal;development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by;hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the;specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript;variants have been described.
  • Synonyms
  • ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase live
Cat.#:ALPL-327HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ALPL Protein, His-tagged
+Inquiry
Cat.#:ALPL-001HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ALPL Protein, His-tagged
+Inquiry
Cat.#:ALPL-1299MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ALPL Protein (20-503 aa), His-tagged
+Inquiry
Cat.#:ALPL-2155RTag:His|SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat ALPL Protein (18-501 aa), His-SUMO-tagged
+Inquiry
Cat.#:Alpl-5784MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Alpl Protein, His-tagged
+Inquiry
Cat.#:ALPL-1994HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALPL Protein, MYC/DDK-tagged
+Inquiry
Cat.#:Alpl-444MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Alkaline Phosphatase, Liver/Bone/Kidney, His-tagged
+Inquiry
Cat.#:ALPL-386HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ALPL Protein, His-tagged
+Inquiry
Cat.#:ALPL-387HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALPL Protein, His-tagged
+Inquiry
Cat.#:ALPL-494HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALPL Protein, GST-tagged
+Inquiry
Cat.#:ALPL-894HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALPL, His tagged
+Inquiry
Cat.#:ALPL-9597HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALPL, GST-tagged
+Inquiry
Cat.#:Alpl-1494MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Alpl protein, His-tagged
+Inquiry
Cat.#:ALPL-1575MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALPL Protein
+Inquiry
Cat.#:Alpl-976MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Alpl Protein, Fc-tagged
+Inquiry
Cat.#:Alpl-977MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Alpl Protein, His-tagged
+Inquiry
Cat.#:ALPL-641RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALPL Protein
+Inquiry
Cat.#:ALPL-310RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ALPL Protein, His-tagged
+Inquiry
Cat.#:ALPL-6912CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ALPL
+Inquiry
Cat.#:ALPL-11240ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALPL
+Inquiry
Cat.#:ALPL-25HTag:N/A
Source (Host):Human placentaSpecies:Human
Product nameNative Human ALPL Protein
+Inquiry
Cat.#:ALPL-5324HTag:N/A
Source (Host):Human liverSpecies:Human
Product nameNative Human Alkaline Phosphatase
+Inquiry
Cat.#:ALPL-8004HTag:N/A
Source (Host):Human liverSpecies:Human
Product nameNative Human Liver Alkaline Phosphatase
+Inquiry
Cat.#:ALPL-66CTag:N/A
Source (Host):Species:Calf
Product nameNative Calf Alkaline Phosphatase
+Inquiry
Cat.#:ALPL-3092HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALPL cell lysate
+Inquiry
Cat.#:ALPL-P04HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ALPL therapeutic protein
+Inquiry

Involved Pathway

ALPL involved in several pathways and played different roles in them. We selected most pathways ALPL participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Folate biosynthesis
ALPPL2; ALPI.2; GGH; MOCS2; ALPL; ALP3; GCH2; GCH1; DHFR; ALPI
Metabolic pathways
NDUFA1; EARS2; CYCS; UQCR10; MIBP; HSD17B12B; COX6B2; DHCR24; IDH2; PIP5K1C

Protein Function

ALPL has several biochemical functions, for example, alkaline phosphatase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALPL itself. We selected most functions ALPL had, and list some proteins which have the same functions with ALPL. You can find most of the proteins on our site.
Function
Related Protein
Function alkaline phosphatase activity
Related Protein ALPPL2; ALPP; ALPI.1; ALPL; ALP3; ALPI
Function metal ion binding
Related Protein C6AST3; SMYD4; ZNF41; CAPN8; ZFP14; GDPD2; ITGB1BP3; TRMT1; PPTC7; ZBTB16A
Function protein binding
Related Protein GLRX3; KCNA5; TMPO; EIF5B; ADCK5; GAB3; LTF; CLPTM1; EPS8L1; BIRC3
Function pyrophosphatase activity
Related Protein CANT1B; GMPS; DOM3Z; CANT1A; PRUNE2; NUDT19; PHOSPHO1; ALPL

Interacting Protein

ALPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALPL here. Most of them are supplied by our site. Hope this information will be useful for your research of ALPL.
MAP3K14; TRAF2; TRAF3; EIF4A2; lrp; NFKBIA; RELA

ALPL Related Articles

Xie, M; Xing, GF; et al. Functional role of EMMPRIN in the formation and mineralisation of dental matrix in mouse molars. JOURNAL OF MOLECULAR HISTOLOGY 46:21-32(2015).
Maeland, JA; Radtke, A; et al. Comparison of Z and R3 antigen expression and of genes encoding other antigenic markers in invasive human and bovine Streptococcus agalactiae strains from Norway. VETERINARY MICROBIOLOGY 167:729-733(2013).