APOA1 Protein, apolipoprotein A-I


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Official Full Name apolipoprotein A-I
Background This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
Synonyms APOA1; apolipoprotein A-I; apo-AI; Sep2; Alp-1; Ltw-1; Sep-1; Sep-2; Apoa-1; Brp-14; Lvtw-1
    • Species :
    • Bovine
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • Dog
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human cells
    • Human Plasma
    • Human Plasma HDL
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APOA1-1060H Recombinant Human ApoA1 Protein Human cells His
    Bovine APOA1-1331B Recombinant Bovine APOA1 Protein (25-265 aa), His-tagged Yeast His
    Mouse Apoa1-631M Recombinant Mouse Apoa1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human APOA1-217H Recombinant Human APOA1, C13&N15-labeled HEK293 N/A
    Human APOA1-2478H Recombinant Human APOA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human APOA1-256H Native Human APOA1 protein Human Plasma HDL N/A
    Human APOA1-26120TH Recombinant Human APOA1, Protein A-tagged E.coli N/A
    Human APOA1-26121TH Native Human APOA1, Protein A-tagged N/A
    Human APOA1-2H Human Apolipoprotein AI (Apo AI) Reference Standard N/A
    Human APOA1-3088HCL Recombinant Human APOA1 cell lysate Human Cell N/A
    Human APOA1-33H Recombinant Human APOA1, Fc tagged Human Cell Fc
    Human APOA1-34H Recombinant Human APOA1 protein, His-tagged HEK293 His
    Human APOA1-523H Recombinant Human APOA1, His tagged E.coli His
    Human APOA1-5301H Native Human Apolipoprotein A-I Human Plasma N/A
    Human APOA1-689H Recombinant Human APOA1 protein, GST-tagged Wheat Germ GST
    Human APOA1-6916H Recombinant Human Apolipoprotein A-I, His-tagged E.coli His
    Human APOA1-698H Recombinant Human APOA1 protein E.coli N/A
    Human APOA1-8034H Native Human ApoLipoprotein Human Plasma N/A
    Human APOA1-9747H Recombinant Human APOA1, GST-tagged E.coli GST
    Human ApoA-I-3554H Native Human ApoA-I Human plasma N/A
    Mouse APOA1-1497MCL Recombinant Mouse APOA1 cell lysate Human Cell N/A
    Mouse Apoa1-38M Recombinant Mouse Apoa1, His-tagged E.coli His
    Mouse Apoa1-6864M Recombinant Mouse Apoa1, Fc tagged Human Cell Fc
    Mouse Apoa1-7404M Recombinant Mouse Apoa1, His tagged Human Cell His
    Rat APOA1-717R Recombinant Rat APOA1 Protein Mammalian Cell His
    Rat ApoA1-8446R Recombinant Rat ApoA1 E.coli N/A
    Cynomolgus Monkey APOA1-303C Recombinant Cynomolgus APOA1 Protein, His-tagged Mammalian Cell His
    Dog APOA1-23D Native Dog Apolipoprotein A1 (APOA1) Protein Dog N/A
    Rabbit APOA1-2726R Recombinant Rabbit APOA1 protein, His-tagged E.coli His
    Chicken APOA1-7073C Recombinant Chicken APOA1 Mammalian Cell His
    Pig APOA1-2725P Recombinant Pig APOA1 protein, His & GST-tagged E.coli His/GST

    APOA1 involved in several pathways and played different roles in them. We selected most pathways APOA1 participated on our site, such as PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PPAR signaling pathway CYP4A14; ACSBG1; FABP6; APOA1; APOA5; PPARAB; FABP7; CD36; PPARA; ME1
    Fat digestion and absorption PNLIPRP1; MTTP; CD36; DGAT1; GOT2; PPAP2C; PPAP2B; Cel; PLA2G5; CLPS
    Vitamin digestion and absorption SCARB1; GIF; APOA1; ABCC1; RBP2; LRAT; APOB; FOLH1; LMBRD1; SLC19A3
    African trypanosomiasis IL10; VCAM1; HBA2; IL6; IL1B2; APOL1; LAMA4; Fasl; PLCB1; PRKCG

    APOA1 has several biochemical functions, for example, apolipoprotein A-I receptor binding, apolipoprotein receptor binding, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA1 itself. We selected most functions APOA1 had, and list some proteins which have the same functions with APOA1. You can find most of the proteins on our site.

    Function Related Protein
    apolipoprotein A-I receptor binding NR1H2; APOA1; CDC42
    apolipoprotein receptor binding APOA1; APOA2; PCSK9
    beta-amyloid binding OLFM1; MAPK8IP2; LDLRAP1; BACE1; PION; APBB2; APBB1; IDE; APOEA; APBA2
    chemorepellent activity SEMA3H; SEMA3GA; EPHA7; APOA1; SEMA3D; SEMA3C; SEMA4BA; EFNA5; SEMA6E; Sema3f
    cholesterol binding APOA1; PMP2; OSBPL2; APOC3; OSBPL7; APOF; SYP; NPC1; APOD; OSBPL1A
    contributes_to cholesterol transporter activity ABCG5; ABCG8; APOA2; APOA1; SFRP5
    cholesterol transporter activity STAR; APOA4; ABCA1; APOA4B.1; APOA1A; APOA1; APOEB; APOA5; APOB; ABCG1
    enzyme binding GSTM3; DDX5; CBX4; MDM2; TMBIM6; PPP1R3B; NOP14; ATG3; SUPT5H; P4HB
    high-density lipoprotein particle binding APOA1A; APOA1; GPIHBP1; APOL2; APOA2
    high-density lipoprotein particle receptor binding APOA1; APOA2; APOC3
    identical protein binding PYDC3; ZBTB16; PPPDE2; SETX; PTS; SERPINA1E; CORO1B; KCNJ2; PKD2; HJURP
    lipase inhibitor activity APOA2; APOC3; APOC1; APOA1; APOC2; FAF2
    phosphatidylcholine binding APOA4; RPE65; GPR12; APOA4B.1; NF1; APOA2; APOA5; APOA4A; APOC1; GPR119
    phosphatidylcholine-sterol O-acyltransferase activator activity APOC1; APOEA; APOA1; APOA5; APOA1A; APOA4A; APOA4B.1; APOA4; APOE; APOA2
    phospholipid binding RASAL1; TICAM2; NR5A1; APOA2; STAP1; APOA1; SERPINB1A; ESYT1; PLA2G2A; FABP1
    phospholipid transporter activity ABCA4; ABCA4A; ABCA1; ATP8B5; MFSD2A; ABCA7; MFSD2AB; MTTP; ABCA13; APOA1
    protein binding DOK2; MYCBP2; C1orf109; SPC25; GZMB; RD3; USHBP1; LLGL1; UBA3; COA5

    APOA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA1.

    APP; HP

    Verhoeven, V; Van der Auwera, A; et al. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: a double blind, placebo controlled randomized trial. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 15:-(2015).
    Liting, P; Guoping, L; et al. Apolipoprotein B/apolipoprotein A1 ratio and non-high-density lipoprotein cholesterol Predictive value for CHD severity and prognostic utility in CHD patients. HERZ 40:1-7(2015).

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