apoa1
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  • Official Full Name
  • apolipoprotein A-I
  • Background
  • This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • APOA1; apolipoprotein A-I; apo-AI; Sep2; Alp-1; Ltw-1; Sep-1; Sep-2; Apoa-1; Brp-14; Lvtw-1
Cat.#:APOA1-1060HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ApoA1 Protein
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Cat.#:APOA1-1331BTag:His
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine APOA1 Protein (25-265 aa), His-tagged
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Cat.#:APOA1-2478HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1 Protein, MYC/DDK-tagged
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Cat.#:APOA1-26120THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA1, Protein A-tagged
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Cat.#:APOA1-217HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1, C13&N15-labeled
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Cat.#:APOA1-33HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1, Fc tagged
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Cat.#:APOA1-34HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1 Protein, His-tagged
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Cat.#:APOA1-523HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA1, His tagged
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Cat.#:APOA1-689HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APOA1 protein, GST-tagged
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Cat.#:APOA1-6916HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Apolipoprotein A-I, His-tagged
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Cat.#:APOA1-698HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human APOA1 protein
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Cat.#:APOA1-9747HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA1, GST-tagged
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Cat.#:Apoa1-38MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Apoa1, His-tagged
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Cat.#:Apoa1-6864MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Apoa1, Fc tagged
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Cat.#:Apoa1-7404MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Apoa1, His tagged
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Cat.#:APOA1-717RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat APOA1 Protein
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Cat.#:ApoA1-8446RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat ApoA1
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Cat.#:APOA1-303CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus APOA1 Protein, His-tagged
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Cat.#:APOA1-2726RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit APOA1 protein, His-tagged
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Cat.#:APOA1-7073CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken APOA1
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Cat.#:APOA1-2725PTag:His|GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig APOA1 protein, His & GST-tagged
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Cat.#:APOA1-256HTag:N/A
Source (Host):Human Plasma HDLSpecies:Human
Product nameNative Human APOA1 protein
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Cat.#:APOA1-26121THTag:N/A
Source (Host):Species:Human
Product nameNative Human APOA1, Protein A-tagged
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Cat.#:APOA1-5301HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Apolipoprotein A-I
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Cat.#:APOA1-8034HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human ApoLipoprotein
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Cat.#:ApoA-I-3554HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human ApoA-I
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Cat.#:APOA1-23DTag:N/A
Source (Host):DogSpecies:Dog
Product nameNative Dog Apolipoprotein A1 (APOA1) Protein
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Cat.#:APOA1-3088HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1 cell lysate
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Cat.#:APOA1-1497MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse APOA1 cell lysate
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Cat.#:APOA1-2HTag:N/A
Source (Host):Species:Human
Product nameHuman Apolipoprotein AI (Apo AI) Reference Standard
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Involved Pathway

APOA1 involved in several pathways and played different roles in them. We selected most pathways APOA1 participated on our site, such as PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
APOC3; CYP7A1A; PLIN1; FABP4; APOA2; AQP7; ACADL; APOA1; Scd2; HMGCS2
Fat digestion and absorption
CLPS; PLA2G2E; PPAP2A; PLA2G12A; ACAT2; APOA1; PPAP2C; SCARB1; MTTP; SLC27A4
Vitamin digestion and absorption
TCN2; FOLH1; ABCC1; MMACHC; SLC19A2; APOA4; APOB; APOA1; BTD; SLC19A3
African trypanosomiasis
ICAM1; GNAQ; HPR; F2RL1; IL18; IL10; PLCB2; PLCB4; HBB-B2; HBA2

Protein Function

APOA1 has several biochemical functions, for example, apolipoprotein A-I receptor binding, apolipoprotein receptor binding, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA1 itself. We selected most functions APOA1 had, and list some proteins which have the same functions with APOA1. You can find most of the proteins on our site.
Function
Related Protein
Function apolipoprotein A-I receptor binding
Related Protein NR1H2; CDC42; APOA1
Function apolipoprotein receptor binding
Related Protein PCSK9; APOA2; APOA1
Function beta-amyloid binding
Related Protein IDE; BACE2; GPRASP2; TGFB2; CST3; APOEB; HSD17B10; ACHE; LDLRAP1; NGFR
Function chemorepellent activity
Related Protein SEMA3E; SEMA6E; UBE4A; SEMA6A; SEMA3BL; SEMA6D; SEMA3FA; SEMA3GA; EFNA5; SEMA4A
Function cholesterol binding
Related Protein APOA4A; OSBP2; NPC2; ANXA6; STAR; ABCA1; TSPO2; APOA2; ERLIN1; OSBPL2
Function contributes_to cholesterol transporter activity
Related Protein SFRP5; ABCG8; APOA2; ABCG5; APOA1
Function cholesterol transporter activity
Related Protein APOA5; APOE; ABCG1; ABCG4B; APOA4A; STAR; APOA1A; APOA4B.2; ABCA1B; APOA4B.1
Function enzyme binding
Related Protein LDB2; MLEC; CASP2; GSTM1; HDAC3; USP22; CYP1A1; UGT1A9; PYCARD; Il6ra
Function high-density lipoprotein particle binding
Related Protein GPIHBP1; APOA1A; APOA2; APOL2; APOA1
Function high-density lipoprotein particle receptor binding
Related Protein APOA2; APOA1; APOC3
Function identical protein binding
Related Protein STK10; POLG2; SDCBP; SOX10; RUNX1T1; SH2B2; C1QTNF2; TLE1; ADIPOR2; KLHL7
Function lipase inhibitor activity
Related Protein APOC2; APOA1; APOC3; APOA2; APOC1; FAF2
Function phosphatidylcholine binding
Related Protein APOC1; APOA4A; SERPINA5; APOA2; GPR119; NF1; VPS24; ESYT2; APOA4; APOA4B.1
Function phosphatidylcholine-sterol O-acyltransferase activator activity
Related Protein APOA2; APOA5; APOA1; APOA4; APOA1A; APOEB; APOA4B.2; APOA4A; APOA4B.1; APOEA
Function phospholipid binding
Related Protein STAP1; SEC14L2; PLA2G7; SPTBN1; BAIAP2L2; WDFY4; PLA2G2A; APOA2; APOEB; PON1
Function phospholipid transporter activity
Related Protein OSBPL5; CETP; MFSD2AB; APOA1; MFSD2AA; ABCA7; MTTP; ATP8B5; MFSD2A; ABCA4A
Function protein binding
Related Protein CCND1; NADK; CYSLTR2; GNB5; PSMB9; CADM1; AP5S1; SH2D2A; FCGR2C; GTPBP4

Interacting Protein

APOA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA1.
APP; HP

APOA1 Related Articles

Verhoeven, V; Van der Auwera, A; et al. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: a double blind, placebo controlled randomized trial. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 15:-(2015).
Liting, P; Guoping, L; et al. Apolipoprotein B/apolipoprotein A1 ratio and non-high-density lipoprotein cholesterol Predictive value for CHD severity and prognostic utility in CHD patients. HERZ 40:1-7(2015).