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Recombinant Rabbit APOA1 protein, His-tagged

Cat.No. : APOA1-2726R
Product Overview : Recombinant Rabbit APOA1 aa. (Asp25~Gln265 (Accession # NM_001101687.1)) fused with N-terminal His tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Source : E. coli
Species : Rabbit
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 28.9kDa
Protein length : Asp25~Gln265 (Accession # NM_001101687.1)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.6.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : APOA1 apolipoprotein A1 [ Oryctolagus cuniculus (rabbit) ]
Official Symbol : APOA1
Synonyms : apo-AI; apoA-I; apolipoprotein A-I
Gene ID : 100009253
mRNA Refseq : NM_001101687.1
Protein Refseq : NP_001095157.1
UniProt ID : P09809

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (17)

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Can APOA1 protein be used as a diagnostic marker for cardiovascular diseases? 04/29/2023

Measurement of APOA1 protein levels is not commonly used as a standalone diagnostic marker for cardiovascular diseases. However, it is often measured as part of lipid profiles to assess the risk of cardiovascular events.

Are there any genetic variations that lead to increased levels of APOA1 protein? 12/18/2022

While rare, some genetic mutations can lead to elevated APOA1 protein levels. However, the impact of increased APOA1 levels on overall health and disease risk is not yet fully understood.

Can the APOA1 protein be used as a diagnostic marker for cardiovascular diseases? 01/04/2022

APOA1 protein levels are commonly measured along with other lipid markers during cardiovascular risk assessments. However, a single measurement of APOA1 protein levels is not sufficient for diagnosis and is usually interpreted in conjunction with other clinical factors.

Are there any genetic disorders associated with APOA1 protein mutations? 12/07/2021

Yes, mutations in the APOA1 gene can cause rare genetic disorders such as familial HDL deficiency or Tangier disease. These conditions are characterized by extremely low levels of HDL cholesterol and may lead to premature cardiovascular diseases.

Can lifestyle factors, such as diet and exercise, influence APOA1 protein levels? 10/12/2021

Yes, lifestyle factors can impact APOA1 protein levels and HDL cholesterol levels. Regular exercise, a healthy diet rich in fruits, vegetables, whole grains, and unsaturated fats, can help raise HDL cholesterol levels, potentially increasing APOA1 protein production. Conversely, an unhealthy lifestyle, such as a diet high in saturated fats and sedentary behavior, can lower HDL cholesterol levels.

How does the APOA1 protein promote the efflux of cholesterol from peripheral tissues? 07/20/2021

APOA1 binds to cholesterol and phospholipids in peripheral tissues, such as macrophages. It forms nascent HDL particles, which then accept additional cholesterol from cells. These cholesterol-loaded HDL particles are subsequently transferred to the liver for excretion or recycling.

Can alterations in the APOA1 protein contribute to conditions other than cardiovascular diseases? 01/07/2021

Yes, variations in APOA1 protein levels and functions have been associated with other health conditions. Some studies suggest a potential link between APOA1 protein deficiency and metabolic disorders, including diabetes and obesity.

Are there any known interactions between the APOA1 protein and other proteins or molecules? 07/27/2020

The APOA1 protein interacts with several enzymes, receptors, and other proteins involved in lipid metabolism and inflammation. Some examples include interactions with lecithin-cholesterol acyltransferase (LCAT) for cholesterol esterification and with scavenger receptor class B type 1 (SR-B1) for cholesterol uptake in the liver. These interactions play crucial roles in the function and regulation of HDL metabolism.

Does the APOA1 protein play a role in neurological health? 02/06/2020

Recent research suggests that the APOA1 protein may have neuroprotective effects in the brain. It has been associated with decreased risk of neurodegenerative diseases, such as Alzheimer's disease, and may play a role in synaptic function and repair.

Is there a relationship between APOA1 protein and HDL cholesterol levels? 12/18/2019

Yes, APOA1 is a major component of HDL particles. It plays a crucial role in the formation and maturation of HDL, as well as in the reverse cholesterol transport pathway. Therefore, alterations in APOA1 protein levels or functionality can impact HDL cholesterol levels.

How is the APOA1 protein involved in inflammation and immune responses? 12/12/2019

The APOA1 protein possesses anti-inflammatory properties and can modulate immune responses. It is known to inhibit the production of inflammatory cytokines and adhesion molecules, which play a role in the development of atherosclerosis and other inflammatory conditions.

Can APOA1 protein levels be modified through lifestyle choices? 07/20/2019

Yes, lifestyle choices can influence APOA1 protein levels. Regular exercise, a healthy diet low in saturated fats, and moderate alcohol consumption have been shown to increase levels of APOA1 protein and improve HDL cholesterol levels.

Is there any ongoing research or potential therapeutic interventions targeting the APOA1 protein? 06/09/2019

Researchers are investigating various approaches to boost APOA1 protein levels, such as using synthetic versions of APOA1 or developing drugs that mimic its functions. These strategies aim to enhance reverse cholesterol transport and potentially reduce the risk of cardiovascular diseases.

Are there any therapeutic interventions targeting the APOA1 protein currently being developed? 04/29/2019

Various strategies are being explored, including the use of APOA1 mimetic peptides and gene therapy approaches to increase APOA1 protein levels or enhance its functionality. However, these interventions are still in the preclinical or early clinical trial stages.

Are there any specific diseases or conditions that can result from dysfunctional APOA1 protein? 02/24/2019

Dysfunctional APOA1 protein can contribute to the development of familial hypoalphalipoproteinemia, a condition characterized by low levels of high-density lipoprotein (HDL) cholesterol. Low HDL levels are associated with an increased risk of cardiovascular diseases, such as atherosclerosis and coronary artery disease.

What are the implications of APOA1 protein deficiency? 01/06/2019

APOA1 protein deficiency can lead to impaired reverse cholesterol transport, resulting in increased levels of low-density lipoprotein (LDL) or "bad cholesterol" and decreased levels of HDL. This imbalance is associated with a higher risk of cardiovascular diseases, including atherosclerosis and heart disease.

Is the APOA1 protein solely produced by the liver? 11/24/2016

The liver is the primary site of APOA1 protein synthesis, but it can also be produced by other tissues, such as the intestine. Intestinal APOA1 contributes to the local production of HDL and can influence systemic lipid metabolism.

Customer Reviews (4)

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Reviews
12/17/2021

    I am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.

    08/03/2017

      Its purity and reliability have provided consistent and reliable results in my research.

      07/12/2017

        The prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the APOA1 protein.

        05/10/2017

          The APOA1 protein is of exceptional quality, making it a perfect fit for my experimental needs.

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