cd8a
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  • Official Full Name
  • CD8a molecule
  • Background
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CD8A; CD8a molecule; CD8, CD8 antigen, alpha polypeptide (p32) , T cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte
Cat.#:CD8A--1097HTag:HlgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD8A Protein (Met1-Asp182), HlgG1 Fc-tagged
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Cat.#:CD8A--1098CTag:HlgG1 Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD8A Protein (Met42-Asp223), HlgG1 Fc-tagged
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Cat.#:CD8A-401BTag:His|SUMO
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine CD8A Protein (26-189 aa), His-SUMO-tagged
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Cat.#:CD8A-822MTag:HlgG1 Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD8A Protein (Met1-Tyr196), HlgG1 Fc-tagged
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Cat.#:CD8A-823MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD8A Protein (Met1-Tyr196), His-tagged, Biotinylated
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Cat.#:CD8A-0878HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD8A Protein, GST-Tagged
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Cat.#:CD8A-1158HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CD8a Protein, His-tagged
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Cat.#:CD8A&CD8B-211HTag:His|Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD8A&CD8B protein, His/FLAG-tagged
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Cat.#:CD8A-10982HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD8A, GST-tagged
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Cat.#:CD8A-266HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD8A Protein, His-tagged
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Cat.#:CD8A-272HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CD8A protein, His-tagged
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Cat.#:CD8A-273HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CD8A protein, His-tagged
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Cat.#:CD8A-274HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD8A protein, His-tagged
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Cat.#:CD8A-27890THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD8A
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Cat.#:CD8A-3196HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD8a Molecule, His-tagged, active
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Cat.#:Cd8a-1502MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd8a protein, His & GST-tagged
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Cat.#:Cd8a-2283MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd8a, His tagged
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Cat.#:CD8A-1264RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD8A Protein
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Cat.#:Cd8a-1503RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd8a protein, His-tagged
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Cat.#:Cd8a-28RTag:Fc|His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd8a, Fc tagged
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Cat.#:CD8A-3508CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD8A
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Cat.#:CD8A-3719ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CD8A
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Cat.#:CD8A-1021FTag:His
Source (Host):HEK293Species:Ferret
Product nameRecombinant Ferret CD8A Protein, His-tagged
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Cat.#:CD8A-2493HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD8A cell lysate
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Cat.#:CD8A-2514MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD8A cell lysate
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Cat.#:CD8A-827RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD8A cell lysate
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Cat.#:CD8A-1872FCLTag:N/A
Source (Host):HEK293Species:Ferret
Product nameRecombinant Ferret CD8A cell lysate
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Involved Pathway

CD8A involved in several pathways and played different roles in them. We selected most pathways CD8A participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
BF2; ITGA9; CLDNF; CLDN15LB; PVRL1B; CD80; MAG; CLDN7B; CLDN5A; CNTNAP2
Antigen processing and presentation
LGMN; HSP90AA1; H2-AA; HLA-DQA1; HSPA2; PSME2; HLA-DPB1; NFYB; HLA-DRB3; CD8A
Hematopoietic cell lineage
MME; CD3E; CD1d1; CSF3R; CSF1R; CD59; HLA-DRB3; CD1E; CD3D; CD8B
T cell receptor signaling pathway
NFKBIA; PIK3R5; CD4; PRKCQ; NRAS; CD8A; PIK3CD; FYN; PIK3R1; MAPK12
Primary i
ZAP70; IGLL1; RFX5; RAG1; LCK; ORAI1; TAP1; CD40; IL2RG; BTK
nodeficiency
TNFRSF13B; CD3E; TAP1; LCK; CD4; RFXAP; BTK; CD8B1; RFX5; IGLL1

Protein Function

CD8A has several biochemical functions, for example, MHC class I protein binding, coreceptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD8A itself. We selected most functions CD8A had, and list some proteins which have the same functions with CD8A. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class I protein binding
Related Protein TUBB; PILRB; LILRB1; DERL1; ATP5B; VCP; ATP5A1; CD8A; TAP1; CD244
Function coreceptor activity
Related Protein CD86; IGSF1; RGMB; RAMP3; CCR8; CXCR7B; ZP2; CXCR4; PVRL1; HFE2
Function protein binding
Related Protein SNTB2; SLC25A23; FAN1; DLG1; ANO2; TFPT; COL23A1; CTF1; VPS26A; ARVCF
Function protein homodimerization activity
Related Protein PRLR; WWTR1; STK10; CISD2; COQ9; VPS25; IRAK1; PVRL4; JAM3; IL6R
Function protein kinase binding
Related Protein LATS1; ZFP36; NBEA; PTPRJ; PDPK1; BAG5; FBXW5; PARN; STAP1; PRKRIP1

Interacting Protein

CD8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD8A here. Most of them are supplied by our site. Hope this information will be useful for your research of CD8A.
CDK1; q7ckm5_yerpe; y2573_yerpe; CACYBP

CD8A Related Articles

Chen, SH; Lee, LF; et al. Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model. CANCER IMMUNOLOGY RESEARCH 3:149-160(2015).
Furugaki, K; Cui, L; et al. Intraperitoneal Administration of a Tumor-Associated Antigen SART3, CD40L, and GM-CSF Gene-Loaded Polyplex Micelle Elicits a Vaccine Effect in Mouse Tumor Models. PLOS ONE 9:-(2014).