CDK1

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CDK1

Official Full Name cyclin-dependent kinase 1
Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; cyclin-dependent kinase 1; OTTHUMP00000019659; OTTHUMP00000019660; OTTHUMP00000223862; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cdk1-a; cyclin-dependent kinase 1-A; Cdc 2; CDK 1; CDK1; CDK1_HUMAN; Cell division control protein 2; Cell division cycle 2 G1 to S and G2 to M; Cell Divsion Cycle 2 Protein; Cyclin Dependent Kinase 1; p34 Cdk1; p34 protein kinase 1; cell division cycle 2 like; cell division protein kinase 1-A; cell division control protein 2-A; Cell division control protein 2 homolog 1; cdc-2; xcdc2; cdc2-a
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDK1-2157H Recombinant Human CDK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDK1-653H Recombinant Human CDK1 protein, His-tagged E.coli His
    Mouse Cdk1-854M Recombinant Mouse Cdk1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CDK1/CyclinA2-271H Recombinant Human CDK1/Cyclin A2, GST-tagged, Active Sf9 Insect Cell GST
    Human CDK1/CyclinB1-48H Recombinant Human CDK1/CyclinB1, GST-tagged, Active Insect Cell GST
    Human CDK1-1533H Recombinant Human CDK1, Unactive, GST-tagged Sf9 Insect Cell GST
    Human CDK1-171H Recombinant Human CDK1 Mammalian Cell His
    Human CDK1-213H Recombinant Human CDK1 protein, T7/His-tagged E.coli T7/His
    Human CDK1-2660H Recombinant Human CDK1, GST-His Sf9 Insect Cell His/GST
    Human CDK1-26954TH Recombinant Human CDK1 N/A
    Human CDK1-3143H Recombinant Human CDK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CDK1-31590TH Recombinant Human Human CDK1 Sf9 Insect Cell N/A
    Human CDK1-31592TH Recombinant Human Human CDK1 Sf9 Insect Cell N/A
    Human CDK1-3330H Recombinant Human CDK1, GST tagged Insect Cell GST
    Human CDK1-654H Recombinant Human cyclin-dependent kinase 1, His-tagged Insect Cell His
    Human CDK1-670HCL Recombinant Human CDK1 cell lysate Insect Cell N/A
    Human CDK1-997H Recombinant Human CDK1, GST-tagged E.coli GST
    Human CDK1-998H Recombinant Human Cyclin-Dependent Kinase 1, GST-tagged Sf9 Insect Cell GST
    Mouse CDK1-001MCL Recombinant Mouse CDK1 cell lysate Insect Cell N/A
    Mouse Cdk1-1932M Recombinant Mouse Cdk1 protein, His-tagged E.coli His
    Mouse CDK1-402M Recombinant Mouse Cdk1, His-GST tagged Insect Cell Fc
    Rat CDK1-1299R Recombinant Rat CDK1 Protein Mammalian Cell His
    Rhesus Macaque CDK1-779R Recombinant Rhesus monkey CDK1 Protein, His-tagged Mammalian Cell His
    Chicken CDK1-6866C Recombinant Chicken CDK1 Mammalian Cell His
    Zebrafish CDK1-11844Z Recombinant Zebrafish CDK1 Mammalian Cell His

    CDK1 involved in several pathways and played different roles in them. We selected most pathways CDK1 participated on our site, such as Cell cycle, Oocyte meiosis, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle RAD9; CDC14B; DMC1; GADD45AA; ESCO2; BABAM1; SMC2; ANKLE2; PMF1; TEX15
    Oocyte meiosis PRKACBB; AURKA; YWHAH; CAMK2D2; RBX1; PPP2R1B; CALM3B; IGF1RA; RPS6KA3; CAMK2B1
    p signaling pathway BID; GADD45AA; BAX; MDM4; PTENB; SIAH2L; TSC2; CCNG1; CD82B; RPRMA
    Gap junction KRAS; ADRB3B; ITPR1; TUBB1; TUBA2; GNA15.1; PRKACB; MAPK1; DRD2B; TUBA1L
    Progesterone-mediated oocyte maturation ADCY2B; CCNB3; CPEB3; MAPK9; AKT1; PRKACA; RAF1A; RPS6KA3A; CCNA2; PIK3CB
    Herpes simplex infection FASLG; STAT1; PML; MAPK9; HLA-DMB; OAS2; TAF5L; MED8; HLA-E; PPP1CA
    Epstein-Barr virus infection TBPL1; POLR2F; IKBKG; PSMC6; CD44; POLR1C; PSMD8; HLA-F; HLA-DQA1; HLA-DRA
    Viral carcinogenesis CDK1; PIK3R2; PIK3CD; HIST2H2BE; HDAC10; SND1; HIST1H4G; KAT2A; HIST1H2BB; HNRNPK

    CDK1 has several biochemical functions, for example, ATP binding, Hsp70 protein binding, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK1 itself. We selected most functions CDK1 had, and list some proteins which have the same functions with CDK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding AK4; PKN1; PRKCD; FDXACB1; CHD1L; RUNX2; PAK6; IARS; PIM3; IRAK1
    Hsp70 protein binding METTL21A; FAM119A; BAG6; STUB1; TSACC; C11orf73; PACRG; PPID; DNAJA1; STIP1
    RNA polymerase II carboxy-terminal domain kinase activity CDK13; CDK9; CCNK; CDK1; MAPK1; CDK7; CDK8; CDK12
    cyclin-dependent protein serine/threonine kinase activity CDK17; CDK16; CDK9; CDK13; CDK12; CDKL1; PFTK1; CDK14; CDK11A; MOK
    histone kinase activity CCNB1; BAZ1B; CDK1
    protein binding RBKS; SYMPK; SLC30A1; TMEM171; DZIP3; TBC1D22B; ARHGEF1; PLEKHA2; NEUROG1; MAGEE1
    protein kinase activity CDKL5; SLKA; VRK1; CAMK2D2; BMPR1AA; MAPKAPK2; CHEK1; LMTK2; CSNK1A1; TNIKB
    protein serine/threonine kinase activity ZAK; MAP3K11; ROCK2A; SLKA; PRKCBB; MAPK12; AAK1; ACVRL1; CLK3; PRKCQ

    CDK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK1.

    CCNB1; CKS1B; PKMYT1

    Zhu, BT; Xiahou, ZK; et al. MTHFR promotes heterochromatin maintenance. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 447:702-706(2014).
    Matthess, Y; Raab, M; et al. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. MOLECULAR ONCOLOGY 8:596-608(2014).

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