cdk1
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  • Official Full Name
  • cyclin-dependent kinase 1
  • Background
  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; cyclin-dependent kinase 1; OTTHUMP00000019659; OTTHUMP00000019660; OTTHUMP00000223862; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cdk1-a; cyclin-dependent kinase 1-A; Cdc 2; CDK 1; CDK1; CDK1_HUMAN; Cell division control protein 2; Cell division cycle 2 G1 to S and G2 to M; Cell Divsion Cycle 2 Protein; Cyclin Dependent Kinase 1; p34 Cdk1; p34 protein kinase 1; cell division cycle 2 like; cell division protein kinase 1-A; cell division control protein 2-A; Cell division control protein 2 homolog 1; cdc-2; xcdc2; cdc2-a
Cat.#:CDK1-653HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CDK1 protein, His-tagged
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Cat.#:CDK1/CyclinA2-271HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK1/Cyclin A2, GST-tagged, Active
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Cat.#:CDK1-3143HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDK1 Protein, MYC/DDK-tagged
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Cat.#:CDK1/CyclinB1-48HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CDK1/CyclinB1, GST-tagged, Active
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Cat.#:CDK1-171HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CDK1
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Cat.#:CDK1-213HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK1 protein, T7/His-tagged
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Cat.#:CDK1-2660HTag:His/GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK1, GST-His
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Cat.#:CDK1-26954THTag:
Source (Host):Species:Human
Product nameRecombinant Human CDK1
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Cat.#:CDK1-31590THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Human CDK1
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Cat.#:CDK1-31592THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Human CDK1
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Cat.#:CDK1-3330HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK1, GST tagged
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Cat.#:CDK1-654HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human cyclin-dependent kinase 1, His-tagged
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Cat.#:CDK1-997HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK1, GST-tagged
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Cat.#:Cdk1-1932MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdk1 protein, His-tagged
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Cat.#:CDK1-402MTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Cdk1, His-GST tagged
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Cat.#:CDK1-1299RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDK1 Protein
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Cat.#:CDK1-779RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK1 Protein, His-tagged
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Cat.#:CDK1-6866CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDK1
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Cat.#:CDK1-11844ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK1
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Cat.#:CDK1-1533HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK1, Unactive, GST-tagged
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Cat.#:CDK1-998HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 1, GST-tagged
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Cat.#:CDK1-670HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK1 cell lysate
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Cat.#:CDK1-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CDK1 cell lysate
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Involved Pathway

CDK1 involved in several pathways and played different roles in them. We selected most pathways CDK1 participated on our site, such as Cell cycle, Oocyte meiosis, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
CEP72; SPO11; SGOL1; CDK6; CTDNEP1A; DYNC1H1; ARPP19B; MPEG1; CDKN1BB; CDC16
Oocyte meiosis
MOS; PRKACB; IGF1; CDC16; CPEB1A; SMC1A; YWHAZ; CALM2B; CAMK2G; CALML3
p signaling pathway
PMAIP1; MDM2; CCNG2; PTENA; SERPINB5; ATM; CD82B; SESN1; RRM2; GADD45AA
Gap junction
GNAI2; TUBA8L3; Adcy4; MAPK7; TUBA4L; DRD2B; GJA1; HRASA; PLCB3; TUBA1L2
Progesterone-mediated oocyte maturation
PIK3CA; FZR1; HSP90AA1; CPEB1A; CDK1; MAD1L1; PIK3R3; PIK3R5; ANAPC2; CDC23
Herpes simplex infection
SRSF2B; HLA-B; EIF2AK3; NFKBIAA; TNFRSF1A; ABCB3L1; SRSF7B; HMGN1; TNFSF14; SRSF5
Epstein-Barr virus infection
NCOR2; CD38; PLCG1; MAP2K3; POLR2I; NFKBIB; HSPA1A; HSPA1B; HLA-DRB5; POLR1C
Viral carcinogenesis
HIST1H4H; HDAC4; PIK3R1; LTBR; CDC20; LYN; HIST1H4J; CCND2; VAC14; SKP2

Protein Function

CDK1 has several biochemical functions, for example, ATP binding, Hsp70 protein binding, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK1 itself. We selected most functions CDK1 had, and list some proteins which have the same functions with CDK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACSS3; MAPK12A; EPHB3; MVDA; HELB; ATP8A1; HNRNPU; LRRK2; NEK3; PTK2BB
Function Hsp70 protein binding
Related Protein DNAJC2; ST13; PACRG; CDK1; DNAJB1; TSACC; DNAJC10; RNF207; L7RN6; GPR37
Function RNA polymerase II carboxy-terminal domain kinase activity
Related Protein CDK8; CDK12; CDK13; CDK9; CDK7; CCNK; CDK1; MAPK1
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein ICK; CDK16; MAK; CDK15; CDK4; CDK12; CDK14; CDKL5; CDKL3; CDK5R1
Function histone kinase activity
Related Protein CDK1; CCNB1; BAZ1B
Function protein binding
Related Protein CAMK1; SAMD4A; SBNO2; C10orf96; FUS; KCNJ10; CTNNA2; TUBB2B; NCAPH2; BMPR1A
Function protein kinase activity
Related Protein DCLK1; CCND1; STK4; ABL2; PRKD2; IKBKB; MKNK2B; RAF1B; MAP4K1; TRIO
Function protein serine/threonine kinase activity
Related Protein STK35; PDIK1L; STK40; STK11; STK17A; NUAK1; BMPR2B; SLK; PDK3; LMTK3

Interacting Protein

CDK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK1.
CCNB1; CKS1B; PKMYT1

CDK1 Related Articles

Zhu, BT; Xiahou, ZK; et al. MTHFR promotes heterochromatin maintenance. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 447:702-706(2014).
Matthess, Y; Raab, M; et al. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. MOLECULAR ONCOLOGY 8:596-608(2014).