CHUK
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Official Full Name
conserved helix-loop-helix ubiquitous kinase
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Synonyms
CHUK; conserved helix-loop-helix ubiquitous kinase; TCF16; inhibitor of nuclear factor kappa-B kinase subunit alpha; IkBKA; IKK alpha; IKK1; IKKA; NFKBIKA; TCF-16; IKK-a kinase; I-kappa-B kinase 1; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; Nuclear factor NFkappaB inhibitor kinase alpha; IKBKA; IKK-alpha; nhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.;
- Recombinant Proteins
- Chicken
- Human
- Zebrafish
- E.coli
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- His
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CHUK Related Research Area
CHUK involved in several pathways and played different roles in them. We selected most pathways CHUK participated on our site, such as AGE/RAGE pathway, AKT phosphorylates targets in the cytosol, Activated TLR4 signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHUK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AGE/RAGE pathway | EGFR;AGER;ATF2;JUN;CHUK;MAPK14;LGALS3;DDOST;MMP13 |
| AKT phosphorylates targets in the cytosol | CDKN1A;CHUK;AKT3;CDKN1B |
| Activated TLR4 signalling | S100A12;NOD1;DUSP4;SIGIRR;CHST13;CREB1;PELI1;S100B;ALCAMB |
| Activation of NF-kappaB in B cells | CHUK;MALT1 |
| Acute myeloid leukemia | PIK3CG;SFPI1;AKT1;MTOR;CCND1;PIK3CB;TCF7L2;BRAF;PIM2 |
| Adaptive Immune System | LAIR1;SIGLEC6;FCGR1B;IGHM;KIF2B;TREML4;CTSE;AP2S1;TREM1 |
| Adipocytokine signaling pathway | ACSL4B;RXRBA;IRS1;ACSBG1;G6PCA.1;CD36;SOCS3;ACSL4;SLC2A1 |
| Alternative NF-kappaB pathway |
CHUK has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHUK itself. We selected most functions CHUK had, and list some proteins which have the same functions with CHUK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PRKCG;SMC6;RAD51L1;AK9;NLRP5;KTI12;IKBKB;RPS6KA1;CDK11A |
| IkappaB kinase activity | IKBKE;IKBKB;CHUK |
| protein binding | NUP62;SBNO2;IPO7;HBQ1;HSFY1;NUMB;TRPC4AP;ADAMTSL4;CKM |
| protein heterodimerization activity | SMAD4;PAFAH1B2;TAS1R2;HIST1H2BK;PPARD;EGFR;ADIPOR1;BAX;HIST1H2BE |
| protein homodimerization activity | MID2;PVRL3B;TFAP2B;ADRB2;DCK;GRIK2;MZF1;UGT1A4;FZD9 |
| protein kinase activity | NAT1;FYNA;PKDCCA;FASTKD2;SRPK1A;CAMK1GA;IKBKAP;ACVR1L;BSK146 |
| scaffold protein binding | CRIPT;IKBKB;LRP4;SCN5A;TREM2;MAPK3;KRT15;DLG4;KCNH2 |
CHUK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHUK here. Most of them are supplied by our site. Hope this information will be useful for your research of CHUK.
IKBKG
- Q&As
- Reviews
Q&As (4)
Ask a questionKnockdown of CHUK leads to accumulation of reactive oxygen species (ROS), blocking cellular senescence while promoting pancreatic cancer development.
CHUK is involved in regulating biological processes such as gene expression, cell growth, differentiation and apoptosis.
FOXO3 can bind the promoter sequence of CHUK and regulate its expression.
CHUK has been associated with studies of stroke, nasopharyngeal cancer, and chronic lymphatic leukemia.
Customer Reviews (3)
Write a reviewThe company provides one-stop service, from the purchase of products to the completion of experiments in one go.
The CHUK proteins purchased from your company is suitable for ELISA.
During the experiment, the technician helped me solve the problems in a timely and accurate manner
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