|Official Full Name||catechol-O-methyltransferase|
|Background||Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.|
|Synonyms||COMT; catechol-O-methyltransferase; catechol O-methyltransferase; Catechol O methyltransferase; COMT_HUMAN; EC 220.127.116.11; OTTHUMP00000197748; OTTHUMP00000197749; OTTHUMP00000197750; OTTHUMP00000197751; OTTHUMP00000197846; OTTHUMP00000198331|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
COMT involved in several pathways and played different roles in them. We selected most pathways COMT participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Biogenic Amine Synthesis||COMT; CHAT; DDC; DBH|
|Biological oxidations||CYP2F1; CYP3A5; CYP2C9; ADH4; DPEP2; GSTK1; CYP21A2; CYP3A4; CYP4T8; Sult2a6|
|Dopamine clearance from the synaptic cleft||COMT|
|Dopamine metabolism||COMT; NQO1; DDC|
|Dopaminergic synapse||KIF5A; AKT2; CAMK2G; DRD3; GRIA1; GNG3; PPP3CB; PPP2R5D; GNB3; CREB3|
|Enzymatic degradation of Dopamine by monoamine oxidase||COMT|
|Enzymatic degradation of dopamine by COMT||COMT|
|Estrogen metabolism||NQO1; CYP1B1; CYP1A1; ARSE; ARSD; COMT|
COMT has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by COMT itself. We selected most functions COMT had, and list some proteins which have the same functions with COMT. You can find most of the proteins on our site.
|O-methyltransferase activity||METTL8; RNMTL1A; TOMT; ASMT; COMTA; ASMTL; PRMT8B; PRDM11; METTL7B; NDUFAF5|
|catechol O-methyltransferase activity||COMTB; COMTA; COMT; TOMT|
|magnesium ion binding||IRAK3; NCS1; PPA1B; ATP11C; MAPK12; NT5C1AA; SPHK1; PTEN; NT5C1A; PKMB|
|protein binding||HSPG2; SLC3A1; NDUFA4; CEP290; C12orf50; ANG; INPP5A; WASH1; RNF213; IFNA2|
COMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMT here. Most of them are supplied by our site. Hope this information will be useful for your research of COMT.
TRIP13; vpr; MCC; RGS2; LITAF; XRN2; c9jaw5_human; FN1; 1C; COL1A2; FGF2; RIN1; USP6NL; PPA2; EXO1