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Official Full Name catechol-O-methyltransferase
Background Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Synonyms COMT; catechol-O-methyltransferase; catechol O-methyltransferase; Catechol O methyltransferase; COMT_HUMAN; EC; OTTHUMP00000197748; OTTHUMP00000197749; OTTHUMP00000197750; OTTHUMP00000197751; OTTHUMP00000197846; OTTHUMP00000198331
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COMT-541H Recombinant Human COMT Protein (Met1-Pro271), His-tagged Insect Cell His
    Human COMT-543H Recombinant Human COMT Protein (Met51-Pro271) E.coli N/A
    Human COMT-1253H Recombinant Human Catechol-O-Methyltransferase Human N/A
    Human COMT-126H Recombinant Human Catechol-O-methyltransferase, His-tagged E.coli His
    Human COMT-1688H Recombinant Human COMT Protein, GST-tagged Wheat Germ GST
    Human COMT-1707H Recombinant Human COMT Protein, His-tagged E.coli His
    Human COMT-26252TH Recombinant Human COMT, His-tagged E.coli His
    Human COMT-27960TH Recombinant Human COMT E.coli N/A
    Human COMT-7365HCL Recombinant Human COMT 293 Cell Lysate HEK293 N/A
    Mouse Comt-1670M Recombinant Mouse Comt protein, His-tagged E.coli His
    Mouse COMT-3771M Recombinant Mouse COMT Protein Mammalian Cell His
    Rat Comt-1671R Recombinant Rat Comt protein, His-tagged E.coli His
    Rhesus Macaque COMT-968R Recombinant Rhesus monkey COMT Protein, His-tagged Mammalian Cell His

    COMT involved in several pathways and played different roles in them. We selected most pathways COMT participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biogenic Amine Synthesis COMT; CHAT; DDC; DBH
    Biological oxidations CYP2F1; CYP3A5; CYP2C9; ADH4; DPEP2; GSTK1; CYP21A2; CYP3A4; CYP4T8; Sult2a6
    Dopamine clearance from the synaptic cleft COMT
    Dopamine metabolism COMT; NQO1; DDC
    Dopaminergic synapse KIF5A; AKT2; CAMK2G; DRD3; GRIA1; GNG3; PPP3CB; PPP2R5D; GNB3; CREB3
    Enzymatic degradation of Dopamine by monoamine oxidase COMT
    Enzymatic degradation of dopamine by COMT COMT
    Estrogen metabolism NQO1; CYP1B1; CYP1A1; ARSE; ARSD; COMT

    COMT has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by COMT itself. We selected most functions COMT had, and list some proteins which have the same functions with COMT. You can find most of the proteins on our site.

    Function Related Protein
    O-methyltransferase activity METTL8; RNMTL1A; TOMT; ASMT; COMTA; ASMTL; PRMT8B; PRDM11; METTL7B; NDUFAF5
    catechol O-methyltransferase activity COMTB; COMTA; COMT; TOMT
    magnesium ion binding IRAK3; NCS1; PPA1B; ATP11C; MAPK12; NT5C1AA; SPHK1; PTEN; NT5C1A; PKMB
    protein binding HSPG2; SLC3A1; NDUFA4; CEP290; C12orf50; ANG; INPP5A; WASH1; RNF213; IFNA2

    COMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMT here. Most of them are supplied by our site. Hope this information will be useful for your research of COMT.

    TRIP13; vpr; MCC; RGS2; LITAF; XRN2; c9jaw5_human; FN1; 1C; COL1A2; FGF2; RIN1; USP6NL; PPA2; EXO1

    Hartung, JE; Ciszek, BP; et al. beta(2)- and beta(3)-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. PAIN 155:1346-1355(2014).
    Hu, ZY; Lausted, C; et al. Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity. THERANOSTICS 4:215-228(2014).

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