comt
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  • Official Full Name
  • catechol-O-methyltransferase
  • Background
  • Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
  • Synonyms
  • COMT; catechol-O-methyltransferase; catechol O-methyltransferase; Catechol O methyltransferase; COMT_HUMAN; EC 2.1.1.6; OTTHUMP00000197748; OTTHUMP00000197749; OTTHUMP00000197750; OTTHUMP00000197751; OTTHUMP00000197846; OTTHUMP00000198331
Cat.#:COMT-541HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human COMT Protein (Met1-Pro271), His-tagged
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Cat.#:COMT-543HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMT Protein (Met51-Pro271)
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Cat.#:COMT-1688HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COMT Protein, GST-tagged
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Cat.#:COMT-1253HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Catechol-O-Methyltransferase
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Cat.#:COMT-126HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Catechol-O-methyltransferase, His-tagged
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Cat.#:COMT-1707HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMT Protein, His-tagged
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Cat.#:COMT-26252THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMT, His-tagged
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Cat.#:COMT-27960THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMT
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Cat.#:Comt-1670MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Comt protein, His-tagged
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Cat.#:COMT-3771MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COMT Protein
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Cat.#:Comt-1671RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Comt protein, His-tagged
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Cat.#:COMT-968RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COMT Protein, His-tagged
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Cat.#:COMT-7365HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COMT 293 Cell Lysate
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Involved Pathway

COMT involved in several pathways and played different roles in them. We selected most pathways COMT participated on our site, such as Biogenic Amine Synthesis, Biological oxidations, Dopamine clearance from the synaptic cleft, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biogenic Amine Synthesis
DDC; DBH; CHAT; COMT
Biological oxidations
UGT1B4; CYP4B1; NAT2; UGT1B1; NCOA2; CYP21A2; CYP26A1; CYP1A1; ABHD14B; Sult2a6
Dopamine clearance from the synaptic cleft
COMT
Dopamine metabolism
NQO1; COMT; DDC
Dopaminergic synapse
CLOCK; ITPR1; CREB3L1; KIF5B; CALML3; GNB2; PRKACB; PRKCA; GNAS; GNGT1
Enzymatic degradation of Dopamine by monoamine oxidase
COMT
Enzymatic degradation of dopamine by COMT
COMT
Estrogen metabolism
CYP1A1; CYP1B1; ARSE; ARSD; COMT; NQO1

Protein Function

COMT has several biochemical functions, for example, O-methyltransferase activity, catechol O-methyltransferase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COMT itself. We selected most functions COMT had, and list some proteins which have the same functions with COMT. You can find most of the proteins on our site.
Function
Related Protein
Function O-methyltransferase activity
Related Protein COQ3; METTL21D; METTL7B; PRMT8B; RNMTL1A; METTL21A; COMTA; FBLL1; HENMT1; ASMT
Function catechol O-methyltransferase activity
Related Protein TOMT; COMT; COMTB; COMTA
Function magnesium ion binding
Related Protein GSS; NUAK2; S100P; ENO1B; TESC; ADSSL1; GTPBP5; DCTPP1; DOM3Z; NUDT18
Function protein binding
Related Protein ARHGDIA; LEO1; PJA1; HNF1A; TTI1; ASL; MOS; ZNF10; UNC45A; FLNA

Interacting Protein

COMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMT here. Most of them are supplied by our site. Hope this information will be useful for your research of COMT.
TRIP13; vpr; MCC; RGS2; LITAF; XRN2; c9jaw5_human; FN1; 1C; COL1A2; FGF2; RIN1; USP6NL; PPA2; EXO1

COMT Related Articles

Hartung, JE; Ciszek, BP; et al. beta(2)- and beta(3)-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. PAIN 155:1346-1355(2014).
Hu, ZY; Lausted, C; et al. Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity. THERANOSTICS 4:215-228(2014).