dicer1
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  • Official Full Name
  • dicer 1, ribonuclease type III
  • Background
  • This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
  • Synonyms
  • DICER1; dicer 1, ribonuclease type III; DCR1; MNG1; Dicer; HERNA; RMSE2; endoribonuclease Dicer; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; multinodular goitre 1; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease; DCR-1; Dicer-1; CG4792 gene product from transcript CG4792-RA; Dicer 1 ribonuclease type III; Dicer-1 protein; DICER_HUMAN; Endoribonuclease Dcr-1; ORFNames: CG4792; CG4792-PA; Dcr-1-PA; cg4792; Dcr; dcr 1; Dmel\CG4792; Antagonist decoy receptor for TRAIL/Apo 2L; CD263; Cytotoxic TRAIL receptor 3; DCR1 TNFR; Dctrailr1; Decoy Receptor 1; Decoy TRAIL receptor 1; Decoy TRAIL receptor without death domain; LIT; Lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; mSOB; TNF receptor family member SOB; TNF receptor homolog 1; TNF Related Apoptosis Inducing Ligand Receptor 3; TNF-re ated apoptosis inducing ligand receptor 3; Tnfrh1; TNFRSF10C; Tnfrsf1al1; Tnfrsf23; TRAIL R3; TRAIL receptor 3; TRAIL Receptor Without An Intracellular Domain; TRAILR3; TRID; Tumor necrosis factor receptor p60 homolog 1; Tumor Necrosis Factor Receptor Superfamily Member 10C; Tumor necrosis factor receptor superfamily member 23; Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Cat.#:DICER1-1780HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DICER1 protein, His-tagged
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Cat.#:DICER1-28329THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DICER1, His-tagged
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Cat.#:DICER1-33HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DICER1 protein, MYC/DDK-tagged
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Cat.#:DICER1-4738HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DICER1, GST-tagged
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Cat.#:DICER1-784HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DICER1 protein, MYC/DDK-tagged
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Cat.#:DICER1-1265RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DICER1 Protein, His-tagged
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Cat.#:DICER1-3414CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DICER1
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Cat.#:DICER1-7503ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DICER1
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Involved Pathway

DICER1 involved in several pathways and played different roles in them. We selected most pathways DICER1 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DICER1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MicroRNAs in cancer
SLC45A3; Abcb1b; PRKCG; VEGFA; HRAS; SLC7A1; ROCK1; IKBKB; SOX4; RDX

Protein Function

DICER1 has several biochemical functions, for example, ATP binding, DNA binding, deoxyribonuclease I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DICER1 itself. We selected most functions DICER1 had, and list some proteins which have the same functions with DICER1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PIP4K2B; ABL1; DDX59; STK35L; NUBPL; DHX9; MAT1A; MAT2AB; ERBB2; AURKA
Function DNA binding
Related Protein NUPR1; PURBB; MCMDC2; PRDM10; ZBED4; MECP2; POLR2I; POLR2B; ZNF558; MCM3AP
Function deoxyribonuclease I activity
Related Protein DICER1; DNASE1
Function double-stranded RNA binding
Related Protein ACTN1; ZFP346; OAS1A; RFTN1; TARBP2; OAS3; ILF2; OASL; DHX58; DDX21
Function endoribonuclease activity
Related Protein CPSF3; RNASEL; RCL1; SMG6; TSN; ERN1; ENDOU2; ENDOU; DROSHA; RNASEKA
Function helicase activity
Related Protein DHX57; BAT1; YTHDC2; CHD7; DHX33; ATRX; ACTG2; BLM; FANCM; SNRNP200
Function metal ion binding
Related Protein LIMCH1A; PDSS1; FAM20B; ADHFE1; ZFP106; THAP4; CARNS1; SMAD1; ZFP354A; SP8B
Function miRNA binding
Related Protein AGO2; TRIM71; RBM4; DICER1; TARBP2; AGO1; AGO4; SOX2; POU5F1; MEF2C
Function pre-miRNA binding
Related Protein XPO5; DICER1; TARBP2
Function contributes_to pre-miRNA binding
Related Protein XPO5; RAN; DICER1; TARBP2
Function protein binding
Related Protein KRTAP10-11; CDH1; GP5; NAA11; MEPE; TXN2; CREB3L1; APOH; MAGEB6; CLIC1
Function protein domain specific binding
Related Protein TNFAIP1; PRKCZ; RAN; RQCD1; PLAUR; CNTLN; PLG; HNRNPM; HIST1H4D; FOXH1
Function ribonuclease III activity
Related Protein DROSHA; RNASEN; BARHL1; DICER1; MRPL44; AGFG1A
Function siRNA binding
Related Protein MECP2; TARBP2; AGO2; TLR9; DICER1; TLR7

Interacting Protein

DICER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DICER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DICER1.
AGO2; TARBP2

DICER1 Related Articles

Devouassoux-Shisheboran, M; et al. Ovarian cancer: molecular biology. ONCOLOGIE 16:306-312(2014).
Stewart, CJR; Alexiadis, M; et al. An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord stromal tumors. HUMAN PATHOLOGY 44:2774-2781(2013).