EPOR Protein, Erythropoietin Receptor

EPOR

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EPOR

Official Full Name Erythropoietin Receptor
Background This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
Synonyms EPOR; erythropoietin receptor; EPO-R; MGC138358
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Rabbit
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EPOR-2045H Recombinant Human EPOR Protein, Fc/His-tagged HEK293 Fc/His
    Human CAB11532RH Rabbit Anti-Human Erythropoietin Receptor Monoclonal Antibody Rabbit N/A
    Human EPOR & CD131-1943HCL Recombinant Human EPOR & CD131 cell lysate Human Cell N/A
    Human EPOR-194H Recombinant Human EPOR protein, His-tagged Insect Cell His
    Human EPOR-2055HCL Recombinant Human EPOR cell lysate Human Cell N/A
    Human EPOR-27012TH Recombinant Human EPOR, Fc-tagged Fc
    Human EPOR-28H Recombinant Human EPOR, Fc tagged Human Cell Fc
    Human EPOR-29H Recombinant Human EPOR Protein, Fc-tagged HEK293 Fc
    Human EPOR-3424H Recombinant Human EPOR Protein, GST-tagged Wheat Germ GST
    Human EPOR-3851H Recombinant Human EPOR, His tagged Human Cell His
    Human EPOR-4114H Recombinant Human Etythropoietin Receptor, Fc-tagged Human Fc
    Human EPOR-598H Recombinant Human EPOR protein, His & GST-tagged E.coli His/GST
    Human EPOR-599H Recombinant Human EPOR protein, His & GST-tagged E.coli His/GST
    Mouse Epor-212M Recombinant Mouse Epor, Fc-His tagged Human Cell Fc/His
    Mouse Epor-2290M Recombinant Mouse Epor, His tagged Human Cell His
    Mouse EPOR-2582MCL Recombinant Mouse EPOR cell lysate Human Cell N/A
    Mouse Epor-461M Recombinant Mouse Erythropoietin Receptor, Fc-tagged NS0 Fc
    Mouse Epor-464M Recombinant Mouse Erythropoietin Receptor NS0 N/A
    Mouse Epor-499M Recombinant Mouse Epor, Fc-tagged Insect Cell Fc
    Mouse Epor-600M Recombinant Mouse Epor protein, His-tagged E.coli His
    Rat Epor-601R Recombinant Rat Epor protein, His-tagged E.coli His
    Zebrafish EPOR-3852Z Recombinant Zebrafish EPOR Mammalian Cell His

    EPOR involved in several pathways and played different roles in them. We selected most pathways EPOR participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL28A; TNFSF11; FIGF; Cxcl15; KIT; GM2506; TGFB1A; IL18R1; IFNB; Il4ra
    PIK-Akt signaling pathway CREB5; TNXB; PCK2; ITGB8; CCNE2; LAMC1; PIK3CA; PPP2R1B; GNG2; Ifna11
    Jak-STAT signaling pathway PTPN2; RAF1B; PTPN11A; Ifna15; PIK3R3A; CCND2A; IL21R; SOCS7; IL19; IFNA16
    Hematopoietic cell lineage Flt3l; CD8A; CSF3R; HLA-DRA; IL5RA; ITGA3; GP1BB; FCER2; CD7; Itga10&Itgb1

    EPOR has several biochemical functions, for example, erythropoietin receptor activity, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPOR itself. We selected most functions EPOR had, and list some proteins which have the same functions with EPOR. You can find most of the proteins on our site.

    Function Related Protein
    erythropoietin receptor activity EPOR
    identical protein binding PAICS; TARDBP; DYNLT1B; NME1; IAPP; SEPHS1; CXADR; MID1; KRTAP10-5; DAPK1
    protein binding RANBP6; GABPB1; DHX8; MTAP1B; SYAP1; SH2D2A; RASSF3; FGF7; THAP6; PRDX1

    EPOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPOR here. Most of them are supplied by our site. Hope this information will be useful for your research of EPOR.

    PTPN6; PTPN1; Cish; INPP5D

    Maxwell, P; Melendez-Rodriguez, F; et al. Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. BRITISH JOURNAL OF HAEMATOLOGY 168:429-442(2015).
    Fujimi, A; Kamihara, Y; et al. Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. INTERNATIONAL JOURNAL OF HEMATOLOGY 100:490-493(2014).

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