"EPOR" Related Products

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Recombinant Human EPOR protein, His-tagged

Cat.No.: EPOR-194H
Product Overview: Recombinant human EPOR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Description: EPOR, also known as Erythropoietin receptor, mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, it dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. So it may also activate the LYN tyrosine kinase.
Source: Insect cell
Species: Human
Tag: His
Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass: 25.6kDa (232aa)28-40kDa (SDS-PAGE under reducing conditions)
AA Sequence: APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGP GNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADTSSFVPLELRV TAASGAPRYH RVIHINEVVL LDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTECVLSNLRGRT RYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLDPHHHH HH
Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity: > 95% by SDS – PAGE
Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 0.5mg/ml (determined by Absorbance at 280nm)
Gene Name: EPOR erythropoietin receptor [ Homo sapiens ]
Official Symbol: EPOR
Synonyms: EPOR; erythropoietin receptor; EPO-R; MGC138358;
Gene ID: 2057
mRNA Refseq: NM_000121
Protein Refseq: NP_000112
MIM: 133171
UniProt ID: P19235
Chromosome Location: 19p13.3-p13.2
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem;
Function: erythropoietin receptor activity; identical protein binding; protein binding; receptor activity;

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