Recombinant Human EPOR Protein, Fc-tagged

• Cat.No.: EPOR-241H
• Product Overview: Recombinant human EPOR protein with Fc tag was expressed in HEK293.

Specification

• Description: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 50.1 kDa
• Protein length: 508
• AA Sequence: MDHLGASLWPQVGSLCLLLAGAAWA PPPNLPDPKFESKAALLAARGPEEL LCFTERLEDLVCFWEEAASAGVGPG NYSFSYQLEDEPWKLCRLHQAPTAR GAVRFWCSLPTADTSSFVPLELRVT AASGAPRYHRVIHINEVVLLDAPVG LVARLADESGHVVLRWLPPPETPMT SHIRYEVDVSAGNGAGSVQRVEILE GRTECVLSNLRGRTRYTFAVRARMA EPSFGGFWSAWSEPVSLLTPSDLDP LILTLSLILVVILVLLTVLALLSHR RALKQKIWPGIPSPESEFEGLFTTH KGNFQLWLYQNDGCLWWSPCTPFTE DPPASLEVLSERCWGTMQAVEPGTD DEGPLLEPVGSEHAQDTYLVLDKWL LPRNPPSEDLPGPGGSVDIVAMDEG SEASSCSSALASKPSPEGASAASFE YTILDPSSQLLRPWTLCPELPPTPP HLKYLYLVVSDSGISTDYSSGDSQG AQGGLSDGPYSNPYENSLIPAAEPL PPSYVACS
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: EPOR erythropoietin receptor [ Homo sapiens (human) ]
• Official Symbol: EPOR
• Synonyms: EPOR; erythropoietin receptor; EPO-R; MGC138358
• Gene ID: 2057
• mRNA Refseq: NM_000121
• Protein Refseq: NP_000112
• MIM: 133171
• UniProt ID: P19235