| Species : |
Human |
| Tag : |
Fc |
| Protein Length : |
25-250 a.a. |
| Description : |
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. |
| Conjugation : |
Fc |
| Tissue specificity : |
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EP |
| Biological activity : |
The ED50 of EPOR-27012TH is typically 0.15-2.5 ng/ml as measured by its ability to neutralize EPO-mediated proliferation of TF-1 cells. |
| Form : |
Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution, short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not rec |
| Purity : |
>95% by SDS-PAGE |
| Storage buffer : |
Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin |
| Storage : |
Store at +4°C. |
| Sequences of amino acids : |
Theoretical sequence:APPPNLPDPKFESKAALLAARGPEELLCF TERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLC RLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASG APRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVL SNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTP SDLDPRIPKVDKKVEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNW YVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCRVSNKALPAPIEKTISKAKGQPREPQVYTLPPSR DELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKT TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK |
| Sequence Similarities : |
Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain. |
