|Official Full Name||EPH receptor A2|
|Background||This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.|
|Synonyms||EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Epha2 involved in several pathways and played different roles in them. We selected most pathways Epha2 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Arf6 signaling events||ADAP1; GULP1; USP6; EFNA1; EGFR; ARAP2; EPHA2; AGTR1; EGF; FBXO8|
|Axon guidance||MARK3; PLXND1; EPHA4; FYN; SEMA3C; CDK5; ACTR2; AP2A1; EFNB2; L1CAM|
|Developmental Biology||JAK1; SCN4A; FRS3; MYF6; EFNA1B; DCC; PEA15; MYOD1; ACTR2B; SPNA1|
|Direct p53 effectors||EPHA2; ZNF385A; SMARCA4; NDRG1; DUSP5; DGCR8; TADA2B; GDF15; AIFM2; HIC1|
|EPH-Ephrin signaling||MYL12B; ARHGEF28; EFNA3B; EPHA2A; ACTR2; EFNB2; ARPC1B; EFNB3; EFNB1; SDCBP|
|EPH-ephrin mediated repulsion of cells||EFNA3B; EFNA1; EPHA2A; AP2S1; EPHA4A; EPHB3A; EPHB4A; EFNA2; EFNA1B; EFNB2|
|EPHA forward signaling||EFNA5; ARHGEF15; EFNA3; CRKL; EPHA2; EFNA1; EFNA2; BLK|
|EPHA-mediated growth cone collapse||EFNA2A; SHB; EFNA1; EPHA2; EFNA1B; EPHA4A; MYL12B; EFNA5; EFNA2; EPHA10|
Epha2 has several biochemical functions, for example, ATP binding, ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha2 itself. We selected most functions Epha2 had, and list some proteins which have the same functions with Epha2. You can find most of the proteins on our site.
|ATP binding||RUNX2B; ACTR2A; AKT2; PTK2BB; SLFNL1; TTN; UCK2B; EPHA4A; KIT; NAIP1|
|ephrin receptor activity||EPHA6; EPHA4A; EPHB4B; EPHA4B; EPHB6; EPHB3A; EPHB4; EPHA10; EPHA2; EPHB3|
|protein binding||TWIST1; FOXJ2; IER3; PTPN12; PIAS1; HYLS1; SPATA13; MYO5A; PDCD1; HTATIP2|
|transmembrane receptor protein tyrosine kinase activity||INSRA; EPHB4B; CSF1RA; NPTN; RYK; EPHA2A; ERBB4A; FLT3; ALK; DDR2|
Epha2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha2.
EFNA1; EPHA7; HSP90AB1; PTK2; saicar; PKM; PTPN11; KPNA3