Epha2
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Official Full Name
EPH receptor A2
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Overview
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders. -
Synonyms
EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Dog
- Human
- Mouse
- Rhesus Macaque
- Baculovirus-Infected Sf9 Cells
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- NS0
- Sf9 Insect Cell
- Wheat Germ
- C
- 6×His
- Fc
- His
- Avi
- Myc
- DDK
- DDK|His
- DYKDDDDK
- Fc Chimera
- Flag
- GST
- His (Fc)
- His|Myc
- MYC
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- Epha2 Related Articles
- Epha2 Related Gene Family
Epha2 involved in several pathways and played different roles in them. We selected most pathways Epha2 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arf6 signaling events | GULP1;ADAP1;ADRB2;AGTR1;EFNA1;EGFR;KIF13B;EGF;ARAP2 |
Axon guidance | PAK3;KIF4;CNTN6;EPHA6;SCN2A;FES;COL9A1A;SEMA6B;DCX |
Developmental Biology | SCN4A;DAB2IPB;CFC1;FRS2B;DUSP2;RNF8;COL6A3;ARPC4;GDF1 |
Direct p53 effectors | TADA2B;CSE1L;GDF15;CTSD;SMARCA4;DUSP5;S100A2;FOXA1;ARID3A |
EPH-Ephrin signaling | EFNA5;EPHA10;ACTR2;ARPC5;ARPC1B;EFNB2;EFNA2;DNM1;KALRNB |
EPH-ephrin mediated repulsion of cells | EFNA1B;EPHA4A;CLTB;EFNB3;EFNA3;EPHA2A;EFNA2;EPHB4B;EPHA10 |
EPHA forward signaling | EPHA2;BLK;CRKL;EFNA1;EFNA2;EFNA3;ARHGEF15;EFNA5 |
EPHA-mediated growth cone collapse | EPHA4A;EFNA4;EFNA2A;EFNA1A;EPHA2;SHB;EPHA10;EPHA2A;EFNA1B |
Epha2 has several biochemical functions, for example, ATP binding, ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha2 itself. We selected most functions Epha2 had, and list some proteins which have the same functions with Epha2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MYH1;PDGFRB;CDC6;NSFB;DDX3X;MCMDC2;PDK3;CSNK1E;PIK3CB |
ephrin receptor activity | EPHB4;EPHA10;EPHA2;EK1;EPHB3;EPHB2B;EPHA4A;EPHB3A;EPHB4B |
protein binding | GNA12;AP2M1;DRD1;UBE3A;HUWE1;SMC4;MAGEB18;C22orf39;ROBO1 |
transmembrane receptor protein tyrosine kinase activity | ROR1;KDRL;KITA;EGFRA;ERBB4A;TRIM27;EPHA4B;EPHB2B;NTRK3A |
Epha2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha2.
EFNA1; EPHA7; HSP90AB1; PTK2; saicar; PKM; PTPN11; KPNA3
- Q&As
- Reviews
Q&As (6)
Ask a questionTherapeutic strategies for EPHA2 include inhibition of its expression, blocking its signal transduction pathway, and modulating its interaction with ligands. These strategies may involve the use of small molecule inhibitors, antibodies, or other types of therapeutics.
The expression level of EPHA2 is associated with the occurrence and progression of a variety of diseases. For example, in tumors such as lung, breast, and colorectal cancer, EPHA2 expression levels may be elevated and correlated with the degree of malignancy and poor prognosis of the tumor.
In some tumors, EPHA2 expression levels are associated with poor prognosis in patients. For example, patients with lung cancer who express EPHA2 often have shorter survival. Therefore, the expression level of EPHA2 may be one of the indicators to predict tumor prognosis.
Some diseases can be diagnosed by measuring EPHA2 expression levels, such as immunohistochemistry, western blotting, and real-time PCR.
Yes, EPHA2 can be used as a target for the treatment of certain diseases. For example, inhibition of EPHA2 expression can inhibit tumor growth and spread, so EPHA2 can serve as a potential therapeutic target. In addition, regulating the expression level of EPHA2 may also be helpful in the treatment of diseases such as the nervous system and cardiovascular system.
EPHA2 can promote cancer metastasis and affect the spread and spread of cancer by regulating processes such as invasion and migration of tumor cells. Therefore, inhibition of EPHA2 expression or blocking its signal transduction pathway may have a potential therapeutic effect on inhibiting cancer metastasis.
Customer Reviews (3)
Write a reviewThe protein has low cytotoxicity.
EPHA2 has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.
Kinetic parameters such as enzymatic reaction rate and binding affinity were tested, and the protein performed well.
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