epha2
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  • Official Full Name
  • EPH receptor A2
  • Background
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
  • Synonyms
  • EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1
Cat.#:Epha2-197MATag:Fc
Source (Host):NS0 CellsSpecies:Mouse
Product nameRecombinant Mouse Epha2 protein, Fc-tagged, APC labeled
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Cat.#:Epha2-197MPTag:Fc
Source (Host):NS0 CellsSpecies:Mouse
Product nameRecombinant Mouse Epha2 protein, Fc-tagged, R-PE labeled
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Cat.#:EPHA2-2027HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA2 Protein, His-tagged
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Cat.#:EPHA2-2515HTag:His|Myc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPHA2 Protein (28-328 aa), His-Myc-tagged
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Cat.#:EPHA2-1903HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA2 Protein, MYC/DDK-tagged
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Cat.#:EPHA2-3378HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPHA2 Protein, GST-tagged
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Cat.#:Epha2-1722MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Eph Receptor A2
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Cat.#:EPHA2-26740THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EPHA2
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Cat.#:EPHA2-300HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EPH Receptor A2, GST-tagged, Active
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Cat.#:EPHA2-359HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA2 Protein, DDK/His-tagged
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Cat.#:EPHA2-360HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHA2 Protein, DDK-tagged
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Cat.#:EPHA2-409HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA2, His tagged
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Cat.#:EPHA2-541HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EPH Receptor A2, His-tagged
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Cat.#:EPHA2-8628HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHA2, His & GST tagged
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Cat.#:Epha2-197MTag:Fc Chimera
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Epha2, Fc Chimera
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Cat.#:Epha2-914MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Epha2, His tagged
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Cat.#:EPHA2-1483RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EPHA2 Protein, His-tagged
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Cat.#:EPHA2-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHA2 cell lysate
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Cat.#:EPHA2-1072HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA2 cell lysate
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Cat.#:EPHA2-2138MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EPHA2 cell lysate
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Cat.#:Kit-0326Tag:N/A
Source (Host):Species:
Product nameEphA2 Kinase (Human) Assay/Inhibitor Screening Assay Kit
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Involved Pathway

Epha2 involved in several pathways and played different roles in them. We selected most pathways Epha2 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arf6 signaling events
USP6; ADRB2; IPCEF1; EGF; EFNA1; EGFR; ADAP1; AGTR1; FBXO8; KIF13B
Axon guidance
KALRN; CLASP1; DCC; NCK1; EFNA3; SEMA3AB; ACTR3; SEMA3AA; EZRA; PTPRA
Developmental Biology
DAB2IPB; EFNA5; CSNK2B; EFNA2A; FOXH1; ADAM23; SIAH2; ARPC4; ARPC3; SCN4A
Direct p53 effectors
PLK3; RNF144B; S100A2; DDX5; CCNK; CSE1L; CEBPZ; DGCR8; HIC1; FDXR
EPH-Ephrin signaling
EFNA3; ARPC2; EFNB1; ARPC1B; AP2S1; EFNA3B; EFNA2; EFNA4; CLTC; EFNA5
EPH-ephrin mediated repulsion of cells
EFNB3; EFNB2A; AP2A2; EFNA4; EPHA2A; EPHB4B; CLTB; EFNB3B; AP2B1; EFNA1
EPHA forward signaling
EFNA2; EFNA5; EPHA2; ARHGEF15; CRKL; EFNA1; EFNA3; BLK
EPHA-mediated growth cone collapse
EFNA3B; EFNA2A; MYL9; KDR; SHB; EFNA4; EFNA5; EPHA4A; EFNA1; EFNA2

Protein Function

Epha2 has several biochemical functions, for example, ATP binding, ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha2 itself. We selected most functions Epha2 had, and list some proteins which have the same functions with Epha2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein STK35; ACVR2AA; TNK1; NMRK1; PDS5B; HK3; RFK; P2RX8; ACSM5; NSFB
Function ephrin receptor activity
Related Protein EPHA2; EK1; EPHB4; EPHA4B; EPHB2B; EPHB6; EPHA2A; EPHA10; EPHB4A; EPHA5
Function protein binding
Related Protein HYAL2; AHI1; KLF13; TRIM43; ERCC3; SAFB2; GRIA2; IER3; AKR1C1; LSM11
Function transmembrane receptor protein tyrosine kinase activity
Related Protein RET; LTK; FLT1; ERBB2; DDR2; PDGFRA; KDRL; ERBB3B; TRIM27; FGFR1A

Interacting Protein

Epha2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha2.
EFNA1; EPHA7; HSP90AB1; PTK2; saicar; PKM; PTPN11; KPNA3

Epha2 Related Articles

Zhang, K; Geddie, ML; et al. Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle. MABS 7:42-52(2015).
Iwahori, K; Kakarla, S; et al. Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells. MOLECULAR THERAPY 23:171-178(2015).

Epha2 Related Gene Family

Cytokines