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Epha2

  • Official Full Name

    EPH receptor A2

  • Overview

    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
  • Synonyms

    EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Dog
  • Human
  • Mouse
  • Rhesus Macaque
  • Baculovirus-Infected Sf9 Cells
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • 6×His
  • Fc
  • His
  • Avi
  • Myc
  • DDK
  • DDK|His
  • DYKDDDDK
  • Fc Chimera
  • Flag
  • GST
  • His (Fc)
  • His|Myc
  • MYC
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EPHA2-2028H Active Recombinant Human EPHA2 Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Met1-Asn534
Human EPHA2-8628H Active Recombinant Human EPHA2 protein, His&GST-tagged Insect Cells His/GST Leu585-Ile976
Human EPHA2-360H Recombinant Human EPHA2 Protein, DDK-tagged Insect Cell DDK Met-Ala24-Val537
Human EPHA2-541H Recombinant Human EPH Receptor A2, His-tagged Sf9 Insect Cell His
Human EPHA2-300H Recombinant Human EPH Receptor A2, GST-tagged, Active Sf9 Insect Cell GST
Human EPHA2-409H Recombinant Human EPHA2, His tagged Human Cell Fc
Human EPHA2-26740TH Recombinant Human EPHA2 Wheat Germ N/A 976 amino acids
Human EPHA2-3378H Recombinant Human EPHA2 Protein, GST-tagged Wheat Germ GST
Human EPHA2-359H Recombinant Human EPHA2 Protein, DDK/His-tagged HEK293 DDK/His Ala24-Val537
Human EPHA2-001HCL Recombinant Human EPHA2 cell lysate Insect Cell N/A
Human EPHA2-1072HCL Recombinant Human EPHA2 cell lysate Human Cell N/A
Human EPHA2-852H Recombinant Human EPHA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EPHA2-2027H Active Recombinant Human EphA2 protein, His-tagged HEK293 His Met1-Asn534
Human EPHA2-698HFL Recombinant Full Length Human EPHA2 Protein, C-Flag-tagged Mammalian cells Flag
Human EPHA2-321H Recombinant Human EPHA2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human EPHA2-0985H Recombinant Human EPHA2 Protein (R561-I976), Tag Free Insect Cell No tag R561-I976
Human EPHA2-151H Recombinant Human EPHA2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human EPHA2-2515H Recombinant Human EPHA2 Protein (28-328 aa), His-Myc-tagged E.coli His/Myc 28-328 aa
Human EPHA2-4343HF Recombinant Full Length Human EPHA2 Protein, GST-tagged In Vitro Cell Free System GST 976 amino acids
Human EPHA2-0986H Recombinant Human EPHA2 Protein (R561-I976), GST tagged Insect Cell GST R561-I976
Human EPHA2-152HF Recombinant Full Length Human EPHA2 Protein In Vitro Cell Free System 976 amino acids
Human EPHA2-5009H Recombinant Human EPHA2 protein, His&Myc-tagged HEK293 His&Myc 24-534aa
Human EPHA2-2576H Active Recombinant Human EPHA2 protein Baculovirus-Infected Sf9 Cells N/A Asp596-Ile976
Human EPHA2-2619H Active Recombinant Human EPHA2 protein, His-tagged HEK293 His Gln25-Asn534
Human EPHA2-227H Recombinant Human EPHA2 protein, His-tagged HEK293 His Ala24-Val537
Human EPHA2-852H-B Recombinant Human EPHA2 Protein Pre-coupled Magnetic Beads HEK293
Human EPHA2-27H Active Recombinant Human EPHA2 Protein (Gln25-Asn534), C-6×His tagged NS0 C-6×His Gln25-Asn534
Human EPHA2-3266H Recombinant Human EPHA2 Protein (Ala24-Asn534), C-Fc tagged Mammalian cells C-Fc Ala24-Asn534
Human EPHA2-1903H Recombinant Human EPHA2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Epha2-197M Active Recombinant Mouse Epha2, Fc Chimera Mammalian cells Fc Chimera
Mouse Epha2-915MB Recombinant Mouse Epha2 protein(Met1-Asn535), His & Avi-tagged, Biotinylated HEK293 C-His-Avi Met1-Asn535
Mouse Epha2-914M Active Recombinant Mouse Epha2 protein(Met1-Asn535), His-tagged HEK293 C-His Met1-Asn535
Mouse Epha2-1722M Active Recombinant Mouse EphA2 protein HEK293 N/A Met1-Asn535
Mouse EPHA2-2138MCL Recombinant Mouse EPHA2 cell lysate Human Cell N/A
Mouse Epha2-197MA Recombinant Mouse Epha2 protein, Fc-tagged, APC labeled Mammalian cells Fc
Mouse Epha2-38M Recombinant Mouse Epha2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Epha2-197MP Recombinant Mouse Epha2 protein, Fc-tagged, R-PE labeled Mammalian cells Fc
Mouse Epha2-38M-B Recombinant Mouse Epha2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Epha2-954M Recombinant Mouse Epha2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Dog EPHA2-01D Recombinant Dog EPHA2 Protein, Fc-tagged HEK293 Fc
Rhesus Macaque EPHA2-1483R Recombinant Rhesus monkey EPHA2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EPHA2-1308R-B Recombinant Rhesus Macaque EPHA2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EPHA2-1308R Recombinant Rhesus Macaque EPHA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-0326 EphA2 Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Epha2 Related Articles
  • Epha2 Related Gene Family

Epha2 involved in several pathways and played different roles in them. We selected most pathways Epha2 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arf6 signaling eventsGULP1;ADAP1;ADRB2;AGTR1;EFNA1;EGFR;KIF13B;EGF;ARAP2
Axon guidancePAK3;KIF4;CNTN6;EPHA6;SCN2A;FES;COL9A1A;SEMA6B;DCX
Developmental BiologySCN4A;DAB2IPB;CFC1;FRS2B;DUSP2;RNF8;COL6A3;ARPC4;GDF1
Direct p53 effectorsTADA2B;CSE1L;GDF15;CTSD;SMARCA4;DUSP5;S100A2;FOXA1;ARID3A
EPH-Ephrin signalingEFNA5;EPHA10;ACTR2;ARPC5;ARPC1B;EFNB2;EFNA2;DNM1;KALRNB
EPH-ephrin mediated repulsion of cellsEFNA1B;EPHA4A;CLTB;EFNB3;EFNA3;EPHA2A;EFNA2;EPHB4B;EPHA10
EPHA forward signalingEPHA2;BLK;CRKL;EFNA1;EFNA2;EFNA3;ARHGEF15;EFNA5
EPHA-mediated growth cone collapseEPHA4A;EFNA4;EFNA2A;EFNA1A;EPHA2;SHB;EPHA10;EPHA2A;EFNA1B

Epha2 has several biochemical functions, for example, ATP binding, ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha2 itself. We selected most functions Epha2 had, and list some proteins which have the same functions with Epha2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYH1;PDGFRB;CDC6;NSFB;DDX3X;MCMDC2;PDK3;CSNK1E;PIK3CB
ephrin receptor activityEPHB4;EPHA10;EPHA2;EK1;EPHB3;EPHB2B;EPHA4A;EPHB3A;EPHB4B
protein bindingGNA12;AP2M1;DRD1;UBE3A;HUWE1;SMC4;MAGEB18;C22orf39;ROBO1
transmembrane receptor protein tyrosine kinase activityROR1;KDRL;KITA;EGFRA;ERBB4A;TRIM27;EPHA4B;EPHB2B;NTRK3A

Epha2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha2.

EFNA1; EPHA7; HSP90AB1; PTK2; saicar; PKM; PTPN11; KPNA3

Zhang, K; Geddie, ML; et al. Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle. MABS 7:42-52(2015).
Iwahori, K; Kakarla, S; et al. Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells. MOLECULAR THERAPY 23:171-178(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the treatment strategies for EPHA2? 08/01/2021

Therapeutic strategies for EPHA2 include inhibition of its expression, blocking its signal transduction pathway, and modulating its interaction with ligands. These strategies may involve the use of small molecule inhibitors, antibodies, or other types of therapeutics.

How does EPHA2 expression level relate to the occurrence and progression of the disease? 07/27/2021

The expression level of EPHA2 is associated with the occurrence and progression of a variety of diseases. For example, in tumors such as lung, breast, and colorectal cancer, EPHA2 expression levels may be elevated and correlated with the degree of malignancy and poor prognosis of the tumor.

How does EPHA2 expression level relate to tumor prognosis? 06/10/2021

In some tumors, EPHA2 expression levels are associated with poor prognosis in patients. For example, patients with lung cancer who express EPHA2 often have shorter survival. Therefore, the expression level of EPHA2 may be one of the indicators to predict tumor prognosis.

How can diseases be diagnosed by detecting EPHA2 expression levels? 05/21/2021

Some diseases can be diagnosed by measuring EPHA2 expression levels, such as immunohistochemistry, western blotting, and real-time PCR.

Could EPHA2 be used as a target for the treatment of certain diseases? 10/18/2020

Yes, EPHA2 can be used as a target for the treatment of certain diseases. For example, inhibition of EPHA2 expression can inhibit tumor growth and spread, so EPHA2 can serve as a potential therapeutic target. In addition, regulating the expression level of EPHA2 may also be helpful in the treatment of diseases such as the nervous system and cardiovascular system.

What is the role of EPHA2 in cancer metastasis? 08/22/2020

EPHA2 can promote cancer metastasis and affect the spread and spread of cancer by regulating processes such as invasion and migration of tumor cells. Therefore, inhibition of EPHA2 expression or blocking its signal transduction pathway may have a potential therapeutic effect on inhibiting cancer metastasis.

Customer Reviews (3)

Write a review
Reviews
12/21/2022

    The protein has low cytotoxicity.

    02/03/2022

      EPHA2 has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.

      03/31/2021

        Kinetic parameters such as enzymatic reaction rate and binding affinity were tested, and the protein performed well.

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