gpi
Share
  • Official Full Name
  • glucose-6-phosphate isomerase
  • Background
  • This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Synonyms
  • GPI; glucose-6-phosphate isomerase; AMF; NLK; PGI; PHI; GNPI; SA36; SA-36; neuroleukin; oxoisomerase; sperm antigen 36; sperm antigen-36; phosphohexomutase; phosphosaccharomutase; phosphohexose isomerase; phosphoglucose isomerase; autocrine motility factor; hexosephosphate isomerase; glucose phosphate isomerase; hexose monophosphate isomerase;
Cat.#:GPI-3928HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPI Protein, GST-tagged
+Inquiry
Cat.#:GPI-2091MTag:His-B2M
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse GPI Protein (2-558 aa), His-B2M-tagged
+Inquiry
Cat.#:GPI-5156HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GPI Protein, GST-tagged
+Inquiry
Cat.#:GPI-27616THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPI, His-tagged
+Inquiry
Cat.#:GPI-28738THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPI, His-tagged
+Inquiry
Cat.#:GPI-387HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human GPI Protein, His-tagged
+Inquiry
Cat.#:GPI-480HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glucose Phosphate Isomer, His-tagged
+Inquiry
Cat.#:GPI-2640RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GPI Protein
+Inquiry
Cat.#:Gpi-723RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gpi protein, His & T7-tagged
+Inquiry
Cat.#:GPI-1280CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GPI
+Inquiry
Cat.#:GPI-5806HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GPI 293 Cell Lysate
+Inquiry

Involved Pathway

GPI involved in several pathways and played different roles in them. We selected most pathways GPI participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
ADH1C; GPI; PGM1; ALDH2; GAPDH; HK2; ALDH2.2; PKM2; ENO3; FBP2
Pentose phosphate pathway
PRPS2; H6PD; G6PD; GPIA; RPE; PFKL; PGLS; RGN; ALDOAB; RPIA
Starch and sucrose metabolism
PGM2; UGT2A2; G6PC2; UGT1A7; Amy1; UGT1A3; AMY2A2; AMY2A5; AMY2A; GBE1
Amino sugar and nucleotide sugar metabolism
GPR19; HK2; TSTA3; GPI; UGP2B; GALK1; HK3; RENBP; GPI1; PGM1
Metabolic pathways
PNLIP; TREH; NME6; QRSL1; PYCR2; AGXT; ACADL; HYKK; TAT; ACSL4
Carbon metabolism
GPI1; PGAM1; ANI_1_2390104; ACADS; RPIA; PGK2; SUCLA2; ESD; ADH5; HK1

Protein Function

GPI has several biochemical functions, for example, cytokine activity, glucose-6-phosphate isomerase activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPI itself. We selected most functions GPI had, and list some proteins which have the same functions with GPI. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein SECTM1; OSTN; Ifnz; IFNA6; Cxcl15; GREM1; TNFSF15; ILTIFB; IL28A; Ccl12
Function glucose-6-phosphate isomerase activity
Related Protein GPI1; GPIB; GPI; GPIA; GPR19
Function growth factor activity
Related Protein IGF3; RABEP1; VEGFAA; NGF; FGF18A; BMP6; BMP7B; LEFTY2; NOV; CECR1A
Function intramolecular transferase activity
Related Protein GPR19; GPI1; GPI
Function monosaccharide binding
Related Protein Siglece; GPI; UPK1A; RPIA; GPI1; GPR19; PGLS; FBP1; TALDO1
Function ubiquitin protein ligase binding
Related Protein STX8; ANKRD32; UBE2J1; USP25; CD40; CASC3; MYOD1; JKAMP; MC4R; SCN5A

Interacting Protein

GPI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPI here. Most of them are supplied by our site. Hope this information will be useful for your research of GPI.
Bles03; Csnk1e; ere_dna; GABARAPL2; MAP1LC3B

GPI Related Articles

Salem, D; Subang, R; et al. beta(2)-Glycoprotein I-specific T Cells Are Associated with Epitope Spread to Lupus-related Autoantibodies. JOURNAL OF BIOLOGICAL CHEMISTRY 590:5543-5554(2015).
Beigneux, AP; Fong, LG; et al. GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding. CIRCULATION RESEARCH 116:624-U152(2015).