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GSK3B

  • Official Full Name

    glycogen synthase kinase 3 beta

  • Overview

    The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
  • Synonyms

    GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GSK3B-326H Active Recombinant Human GSK3B protein, GST-tagged Insect Cell GST
Human GSK3B-1023H Recombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged E.coli GST
Human GSK3B-1540H Recombinant Human GSK3 beta, Unactive, GST-tagged E.coli GST Full length
Human GSK3B-406H Recombinant Human glycogen synthase kinase 3 beta, His-tagged E.coli His
Human GSK3B-376H Recombinant Human GSK3B Protein, His-tagged Insect Cell His
Human GSK3B-1886H Recombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged Insect Cell GST
Human GSK3B-1022H Recombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged Sf9 Insect Cell His
Human GSK3B-28628TH Recombinant Human GSK3B E.coli N/A
Human GSK3B-2649H Recombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged E.coli His
Human GSK3B-616H Active Recombinant Human GSK3B protein, His-tagged Insect Cells His Met1-Thr433
Human GSK3B-28630TH Recombinant Human GSK3B N/A
Human GSK3B-120H Recombinant Human GSK3B Protein, DDK-tagged Insect Cell DDK
Human GSK3B-735H Recombinant Human GSK3B Mammalian Cell His
Human GSK3B-2858H Recombinant Human GSK3B (1-351aa), His-tagged E.coli His
Human GSK3B-2857H Recombinant Human GSK3B (C-79aa), His-tagged E.coli His
Human GSK3B-4399H Recombinant Human GSK3B Protein, GST-tagged Wheat Germ GST
Human GSK3B-717HCL Recombinant Human GSK3B cell lysate Insect Cell N/A
Human GSK3B-012H Recombinant Human GSK3B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human GSK3B-416H Recombinant Human GSK3B protein, His-tagged E. coli His 355-433 aa
Human GSK3B-430HFL Recombinant Full Length Human GSK3B Protein, C-Flag-tagged Mammalian cells Flag
Human GSK3B-2350H Recombinant Human GSK3B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GSK3B-2219H Recombinant Human GSK3B Protein, His-tagged E.coli N-His Lys122-Thr375
Human GSK3B-2997H Recombinant Human GSK3B protein, His-tagged E.coli His 1-420aa
Human GSK3B-2799H Recombinant Human GSK3B Protein (Met1-Thr420), N-GST tagged E.coli N-GST Met1-Thr420
Human GSK3B-2129H Recombinant Human GSK3B Protein (1-420 aa), His-tagged Yeast His 1-420 aa
Human GSK3B-3329HF Recombinant Full Length Human GSK3B Protein, GST-tagged In Vitro Cell Free System GST 433 amino acids
Human GSK3B-8397HF Active Recombinant Full Length Human GSK3B Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-420(end)
Human GSK3B-193H Recombinant Human GSK3B protein, His-tagged E.coli His 426aa
Human GSK3B-6642HF Active Recombinant Full Length Human GSK3B Protein, GST-tagged Insect (sf21) GST 1-420(end)
Human GSK3B-1027H-B Recombinant Human GSK3B Protein Pre-coupled Magnetic Beads HEK293
Human GSK3B-1027H Recombinant Human GSK3B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gsk3b-2521M Active Recombinant Mouse Gsk3b protein, His-tagged Insect Cells His Met1-Thr420
Mouse GSK3B-534MCL Recombinant Mouse GSK3B cell lysate Insect Cell N/A
Mouse Gsk3b-1602M Recombinant Mouse Gsk3b Protein, His-tagged E.coli N-His Lys122-Thr375
Mouse Gsk3b-3318M Recombinant Mouse Gsk3b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GSK3B-2728R Recombinant Rat GSK3B Protein Mammalian Cell His
Rat GSK3B-2382R Recombinant Rat GSK3B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Gsk3b-1603R Recombinant Rat Gsk3b Protein, His-tagged E.coli N-His Lys122-Thr375
Rat GSK3B-2382R-B Recombinant Rat GSK3B Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GSK3B-8957Z Recombinant Zebrafish GSK3B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GSK3B Related Articles
  • GSK3B Related Research Area
  • GSK3B Related Signal Pathway

GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayRPS6KB1;BTC;AKT3A;PLCG2;AKT1;HRASB;PLCG1;ABL2;ERBB4A
Chemokine signaling pathwayPF4V1;PXN;NCF1;RAC2;STAT5B;GRK1;CXCL13;CCL27;GNG5
Cell cycleGINS1;CDKN1B;RAD21B;E2F2;MIS18A;RAD1;KAT5;ORC1L;TUBB4A
PIK-Akt signaling pathwaySPP1;PIK3R2;ITGA1;PPP2R1B;ITGA10;STK11;PPP2R5D;FGFR2;PPP2R3C
Wnt signaling pathwayPRKACBB;TP53;CAMK2D1;RHOAA;WNT4;DAAM1;RAC3B;PLCB1;FZD8A
Hedgehog signaling pathwayWNT3;GAS1;SHHA;SAP18;BMP2B;WNT2BA;WNT5A;GAS1A;DHH
Axon guidanceEPHB2;PHB;ACTR3;CLTB;ROCK1;RASGRP4;EPHA2A;Unc5b;RND1
Hippo signaling pathwayBMP6;CRB2;BMP2;AREG;SMAD2;PARD6A;BIRC5;WNT8A;TEAD4
Focal adhesionBIRC2;MYL9B;XIAP;MAPK8B;VCLA;PDGFAB;ITGA10;COL27A1;MYLK3
Signaling pathways regulating pluripotency of stem cellsLHX5;ID4;NEUROG1;ZFHX3;KRAS;SMAD1;WNT2;FZD2;POU5F1
T cell receptor signaling pathwayPIK3R5;DEF6A;VAV3;VAV1;PPP3CB;SHB;PAK2;CD40LG;CD3E
B cell receptor signaling pathwayNFKB1;ACTR3;PIK3CD;PIK3AP1;PLEKHA2;NFATC3;VAV1;CTNNB2;LILRB3
Neurotrophin signaling pathwayMAPK10;CAMK2D;PIK3R5;BAX;GSK3B;RAPGEF1;NTF3;MAP2K1;MAP3K1
Dopaminergic synapsePPP2R2B;SLC18A2;GNAL;PPP2R5A;GRIA1;PPP2R5B;GNGT1;COMT;PPP2CA
Insulin signaling pathwayAKT1;PRKACG;PHKG2;MKNK2;PTPRFB;SHC2;PKLR;RPS6KB2;CBL
MelanogenesisCAMK2G;PRKACG;WNT5A;MC1R;DVL3A;PRKACAA;EDNRB2;CREB1A;CAMK2A
Prolactin signaling pathwayPIK3R3;SHC4;CCND2;ELF5;KRAS;MAPK11;MAP2K1;SOCS6;GRB2
Thyroid hormone signaling pathwayCASP9;MAP2K2;NCOA3;ITGAV;MDM2;SIN3A;NOTCH2;PLCG1;THRB
Insulin resistancePRKCBA;NR1H3;SLC27A4;G6PC3;PIK3R5;SOCS3;SLC27A1A;GFPT2;G6PC
Non-alcoholic fatty liver disease (NAFLD)NDUFA6;NDUFB1;MLXIPL;IL-8;COX7A2;NDUFB3;PRKAG3;NDUFS4;NDUFC2
Alzheimers diseaseNDUFS2;PSEN1;IL1B2;BAD;FAS;COX7C;UQCRFS1;NAE1;NDUFV2
Hepatitis CPPP2R1B;EIF2AK4;EIF2AK2;IFNAR1;OAS2;Ifna15;STAT3;Ifna11;IFNA16
MeaslesPIK3CA;MAP3K7;CD3D;HSPA2;PIK3CB;STAT2;TBK1;TLR4;IL6
Influenza AIFNA10;HSPA6;EIF2AK3;KPNA1;MAPK13;NFKB1;HSPA1B;IL8L1;CCL2
HTLV-I infectionTGFB1;WNT2B;WNT11;EGR2;FZD9;FZD3;CD3G;NRAS;RRAS
Epstein-Barr virus infectionNEDD4;GSK3B;POLR1C;HDAC4;HSPB2;MAPK13;POLR2D;PSMD7;PTMA
Pathways in cancerPGF;HIF1A;PPARD;GNAQ;SMAD4;MAX;MAP2K2;GNB4;TRAF2
Colorectal cancerPIK3CD;RAC3;DCC;BAX;CCND1;PIK3R2;MAP2K1;MLH1;APC
Endometrial cancerPIK3R1;APC2;HRAS;NRAS;BRAF;MAP2K1;KRAS;PIK3R3;TCF7
Prostate cancerNRAS;Ar;PIK3R2;CPN1;INSRR;SRD5A2;GRB2;PIK3CA;SMARCA4
Basal cell carcinomaWNT9B;PTCH1;WNT16;GLI3;TCF7L2;FZD7;AXIN2;GSK3B;WNT2

GSK3B has several biochemical functions, for example, ATP binding, NF-kappaB binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPIP4K2B;THG1L;AK9;MYO1G;HSPA2;ATP2C2;OXSR1B;PTK6B;TWF2
NF-kappaB bindingEP300;NFKBID;MTDH;HDAC2;ANXA4;FAF1;ANKRD42;HDAC3;BRMS1
RNA polymerase II transcription factor bindingGATA2;MTA2;TRPS1;PITX2;GFI1B;TAL1;MTDH;MIXL1;DHX9
beta-catenin bindingCDH24;GRIP1;LZTS2A;DACT1;APC;LEF1;PTPRU;KLF4;SLC9A3R1
kinase activityRPS6KB1B;BCR;MAPK12B;TLK1B;MAPKAPK2A;TGFBR1A;CKMA;DNAJC3B;NIM1
p53 bindingBLM;ZNF385D;TRP63;CREBBP;TP53BP1;EHMT1;BRD4;RNF20;MDM2
protein bindingMPHOSPH8;MECP2;RABL2;AMY1A;SLC9A1;HSPA2;CSRNP2;ANKRD27;RABGEF1
protein kinase A catalytic subunit bindingPRKAR2B;RYR2;PKIA;CSK;PRKAR2A;PRKAR1B;KCNQ1;GSK3B;PJA2
protein kinase bindingMAP2K6;WAS;BCAR1;IBTK;NME2;SPDYB;TRIM6;ATG13;PTPN6
protein serine/threonine kinase activityMYO3A;PAK3;MAPK6;BMPR1B;CHEK2;CHEK1;MELK;CSNK1G3;PSKH2
tau-protein kinase activityMARK1;PHKG1;PRKAA1;GSK3A;MARK2;PHKG2;CDK5;GSK3B;CSNK1D
ubiquitin protein ligase bindingXRCC5;FOXO1;ARRB1;MFN2;SCAMP3;MAGEA2B;NEDD8;USP2;SMAD3

GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.

AXIN1

Solich, J; Kolasa, M; et al. Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study. PHARMACOLOGICAL REPORTS 67:345-348(2015).
Yuan, YH; Yan, WF; et al. The molecular mechanism of rotenone-induced alpha-synuclein aggregation: Emphasizing the role of the calcium/GSK3 beta pathway. TOXICOLOGY LETTERS 233:163-171(2015).
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