gsk3b
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  • Official Full Name
  • glycogen synthase kinase 3 beta
  • Background
  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
  • Synonyms
  • GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
Cat.#:GSK3B-2350HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GSK3B Protein, MYC/DDK-tagged
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Cat.#:GSK3B-4399HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSK3B Protein, GST-tagged
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Cat.#:GSK3B-1886HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-120HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B Protein, DDK-tagged
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Cat.#:GSK3B-28628THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-28630THTag:
Source (Host):Species:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-326HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B protein, GST-tagged
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Cat.#:GSK3B-376HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human GSK3B Protein, His-tagged
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Cat.#:GSK3B-406HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human glycogen synthase kinase 3 beta, His-tagged
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Cat.#:GSK3B-616HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B, His tagged
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Cat.#:GSK3B-735HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:Gsk3b-2521MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Gsk3b, His tagged
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Cat.#:GSK3B-2728RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GSK3B Protein
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Cat.#:GSK3B-8957ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GSK3B
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Cat.#:GSK3B-2649HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1022HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-1540HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3 beta, Unactive, GST-tagged
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Cat.#:GSK3B-2857HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (C-79aa), His-tagged
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Cat.#:GSK3B-2858HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (1-351aa), His-tagged
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Cat.#:GSK3B-717HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B cell lysate
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Cat.#:GSK3B-534MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse GSK3B cell lysate
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Involved Pathway

GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PAK2B; PAK6B; CAMK2G; GAB1; GRB2; AKT3A; PAK4; RPS6KB1B; ERBB3; MAPK9
Chemokine signaling pathway
NRAS; IL-8; CXCL12; CCL20; ADRBK2; STAT3; VAV2; CXCL14; GNG8; PARD3
Cell cycle
FGFR1OP; CEP290; PKMYT1; CDK5RAP2; GINS3; CSNK2B; ORC6; B9D2; CCND1; ANAPC4
PIK-Akt signaling pathway
EIF4E2; RPTOR; GNB1; IFNA12; INS1; GNG3; FGFR2; GRB2; PDPK1; PPP2R3C
Wnt signaling pathway
WNT9B; CCND1; RAC1; DKK1; RAC2; BAMBIA; DAAM2; WNT10B; TRP53; RBX1
Hedgehog signaling pathway
CSNK1A1L; SUFU; DHH; WNT7AA; LRP2A; PRKACBA; ZIC2; FBXW11; WNT4A; GLI2B
Axon guidance
FES; PAQR3B; MYL12A; EPHB6; CHL1; DUSP6; SLC14A2; DPYSL2B; EPHA2; RND1L
Hippo signaling pathway
FZD5; CDH1; TGFBR2; WNT7B; WNT1; PRKCI; TEAD4; YWHAE; AMH; YWHAZ
Focal adhesion
CDC42; PTENB; THBS3; MLCK2; PAK2A; ARHGAP35; RAF1B; VCL; AASS; ITGB7
Signaling pathways regulating pluripotency of stem cells
SOX2; DLX5; PIK3R5; MAPK1; OTX1; IGF1R; BMP4; BMPR1A; POU5F1; ID2
T cell receptor signaling pathway
NFKBIB; CD3E; CD3D; DBNLB; PIK3R2; HRAS; BCL10; IKBKG; MAP2K1; MAP2K7; SHB
B cell receptor signaling pathway
GSK3AB; DUSP4; PIK3R2; SOS1; ACTR2; RAF1; CDK6; DOK3; NRAS; CD22
Neurotrophin signaling pathway
CAMK2D; GAB1; ZFP110; BRAF; PIK3R1; KRAS; MAPK10; BDNF; MAPK11; Fasl
Dopaminergic synapse
GRIA2; MAPK8; KIF5C; CALM1; PPP2R3C; AKT1; CALY; GRIA1; KCNJ5; ARNTL
Insulin signaling pathway
SOCS2; AKT2; MAP2K1; PRKAR1A; PIK3R3A; FBP1A; SREBF1; INSB; IRS2; SHC2
Melanogenesis
PRKACAA; FZD5; MITF; WNT5B; WNT8A; WNT8B; FZD2; CALM2A; ADCY1A; MAP2K2B
Prolactin signaling pathway
INS2; SOS1; MAPK11; TNFRSF11A; SIRPA; FOXO3; NEK3; AKT2; PIK3CG; SOCS7
Thyroid hormone signaling pathway
AKT2; NCOA3; SIN3A; CASP9; GSK3B; PIK3CA; ITGAV; SLC16A10; KAT2A; ACTB
Insulin resistance
G6PC2; PPP1CBL; G6PCA.1; CREB5; NFKB1; NOS3; AKT2L; PRKAA2; PTPN11B; SLC2A1
Non-alcoholic fatty liver disease (NAFLD)
PIK3CG; ADIPOR2; BID; FAS; NDUFB10; SDHB; NDUFA4; SDHA; PIK3R5; NDUFA5
Alzheimers disease
COX6B2; NDUFS5; GRIN2C; ITPR1; GNAQ; CDK5R1; NDUFV2; UQCRQ; CASP12; SDHC
Hepatitis C
CLDN22; IKBKG; MAVS; MAPK13; OAS1B; CLDN15; IFNA17; TNF; STAT2; IRF3
Measles
SH2D1A; PIK3CG; FAS; IL12B; TLR4; CD28; PIK3CB; CD3E; CD3D; IFNAR1; IL6
Influenza A
NXF2; ADAR; MAPK13; DDX58; HSPA1L; STAT2; OAS1A; SOCS3; IFNA1; IFIH1
HTLV-I infection
WNT11; HLA-DOA; HLA-DRB5; FZD2; MYB; AKT1; TRP53; HLA-DQA2; LTA; TCF3
Epstein-Barr virus infection
POLR3H; CD44; POLR3E; ENTPD3; TRAF6; SHFM1; BCL2; MAPK10; CDK1; SND1
Pathways in cancer
PLD1; Adcy4; FGFR1; CBLB; CTBP2; GNAS; FLT3; CCNA1; CBLC; SFPI1
Colorectal cancer
CYCS; ARAF; Casp3; KRAS; LEF1; TGFBR2; TGFB1; APC; SMAD3; PIK3R5
Endometrial cancer
GSK3B; ERBB2; BAD; PIK3R1; APC; MAPK1; PDPK1; ELK1; PIK3CG; AXIN1
Prostate cancer
IGF1; CCNE2; PDGFB; RB1; FGFR1; CREB3L3; Ar; RELA; CREB5; MAP2K2
Basal cell carcinoma
SUFU; FZD10; WNT7A; FZD1; Fzd4; APC2; FZD2; PTCH1; FZD6; WNT2B

Protein Function

GSK3B has several biochemical functions, for example, ATP binding, NF-kappaB binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACSBG1; TAF1; ATP8B1; NAGK; TRMU; IGF1RB; WARS2; BMPR1AB; MAP3K6; DNAJA4
Function NF-kappaB binding
Related Protein MTDH; COMMD7; RNF25; HDAC3; ANKRD42; COMMD6; RPS3; AP1S2; NFKBID; SNAI1A
Function RNA polymerase II transcription factor binding
Related Protein SPOP; GATA2A; ZFPM2; TP53; PITX2; MTDH; TBX3; ZFPM2A; GATA2B; ZFPM1
Function beta-catenin binding
Related Protein PROP1; CALCOCO1; BCL9L; LEF1; TCF7L1A; AXIN2; DACT2; CDH24; PTPRK; DVL3
Function kinase activity
Related Protein STK24B; DCLK1A; PINK1; NEK1; MAPK8B; CDC7; CKMA; PLK2B; CDK12; PRKD3
Function p53 binding
Related Protein PLK3; SETD7; SMARCA4; BRD7; MDM2; RNF20; TP63; RFWD3; TAF9; NUAK1
Function protein binding
Related Protein BMP1A; HSPB7; PIK3C3; CSNK2A1; TMEM132D; ANXA5; RNASEL; Serpina1b; LOC729991; SYCP1
Function protein kinase A catalytic subunit binding
Related Protein RYR2; SOX9; EZR; GSK3A; PRKAR1A; PRKAR1B; PJA2; PRKAR2A; CSK; PRKAR2B
Function protein kinase binding
Related Protein MSH2; PPP1CC; CLTC; CCNA2; AP2A1; CD3E; PRKAB1; CCND1; SOCS1; GYS1
Function protein serine/threonine kinase activity
Related Protein PRKCA; MAP3K2; BRAF; GM711; TAF1L; STK36; MINK1; STK10; CDK11A; STK39
Function tau-protein kinase activity
Related Protein CSNK1D; PRKAA1; CDK5; GSK3B; MARK2; PHKG1; MARK4; PHKG2; GSK3A; MARK1
Function ubiquitin protein ligase binding
Related Protein UBE2G1B; MUL1; CASC3; TRIM28; UBE2N; ARIH1; BCL2; SKI; KDM4A; MAGEA2B

Interacting Protein

GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.
AXIN1

GSK3B Related Articles

Solich, J; Kolasa, M; et al. Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study. PHARMACOLOGICAL REPORTS 67:345-348(2015).
Yuan, YH; Yan, WF; et al. The molecular mechanism of rotenone-induced alpha-synuclein aggregation: Emphasizing the role of the calcium/GSK3 beta pathway. TOXICOLOGY LETTERS 233:163-171(2015).