gsk3b
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  • Official Full Name
  • glycogen synthase kinase 3 beta
  • Background
  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
  • Synonyms
  • GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
Cat.#:GSK3B-2129HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GSK3B Protein (1-420 aa), His-tagged
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Cat.#:GSK3B-2350HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GSK3B Protein, MYC/DDK-tagged
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Cat.#:GSK3B-4399HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSK3B Protein, GST-tagged
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Cat.#:GSK3B-1886HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-120HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B Protein, DDK-tagged
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Cat.#:GSK3B-28628THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-28630THTag:
Source (Host):Species:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-326HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B protein, GST-tagged
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Cat.#:GSK3B-376HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human GSK3B Protein, His-tagged
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Cat.#:GSK3B-406HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human glycogen synthase kinase 3 beta, His-tagged
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Cat.#:GSK3B-616HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B, His tagged
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Cat.#:GSK3B-735HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:Gsk3b-2521MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Gsk3b, His tagged
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Cat.#:GSK3B-2728RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GSK3B Protein
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Cat.#:GSK3B-8957ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GSK3B
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Cat.#:GSK3B-2649HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1022HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-1540HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3 beta, Unactive, GST-tagged
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Cat.#:GSK3B-2857HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (C-79aa), His-tagged
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Cat.#:GSK3B-2858HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (1-351aa), His-tagged
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Cat.#:GSK3B-717HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B cell lysate
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Cat.#:GSK3B-534MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse GSK3B cell lysate
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Involved Pathway

GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PIK3R5; PAK2B; ERBB3A; GRB2A; AKT2L; SHC1; TGFA; ERBB4; BTC; PTK2AB
Chemokine signaling pathway
GNGT1; GNG7; CCR1L1; CXCL5; RLN1; PIK3CG; CXCL1; CCR3; CXCR6; CCL3L3
Cell cycle
TMEM188; CDCA5; CEP76; CEP152; CSNK2B; CDC16; ESPL1; FAM175A; MCM9; PDS5B
PIK-Akt signaling pathway
CREB3L2; FGF20; FGF9; LAMA4; VWF; KIT; IFNA21; PHLPP2; FGF6; PPP2R2C
Wnt signaling pathway
WNT6; FZD9B; TRP53; PORCNL; WNT8B; WNT3A; CUL1B; CTBP2A; FBXW11B; PORCN
Hedgehog signaling pathway
WNT11R; WNT9B; BMP2; CSNK1G1; PRKACAB; WNT2; WNT16; WNT7AA; PTCH2; SAP18
Axon guidance
GPC1B; EPHB4A; SPTBN2; EGF; NEFLB; COL9A3; PLXNA1; SEMA4C; EFNB2; FES
Hippo signaling pathway
TGFB2; WNT7A; PRKCI; AXIN1; SMAD4; SCRIB; LIMD1; WWC1; SOX2; BMP4
Focal adhesion
PTENA; RAF1B; AASS; RAC3B; VASPA; VWF; PDGFAA; RAF1; BRAF; VAV3
Signaling pathways regulating pluripotency of stem cells
PIK3R3; ID3; GSK3B; WNT9A; NRAS; WNT2B; PIK3CG; WNT8B; HNF1A; INHBA
T cell receptor signaling pathway
DLG1; MUC1; VAV1; IKBKG; PPP3CC; NFKB1; RAF1; NCK1; PAK3; PRKCQ
B cell receptor signaling pathway
MAPK4; BANK1; NFKB1; CSK; ARPC1B; IFITM1; STAP1; VAV2; DOK3; CDK7
Neurotrophin signaling pathway
MAP2K2; RELA; PIK3R5; PIK3CB; SH2B1; PDPK1; NFKBIA; IRS1; NFKBIE; PRDM4
Dopaminergic synapse
PPP1CA; PPP2CA; PLCB1; PRKCB; PPP3CA; SLC6A3; ARNTL; CREB5; PPP2R5B; CALM2
Insulin signaling pathway
EIF4E2RS1; PPARGC1A; IRS1; CALM2A; PRKACBB; FLOT1; PRKAR1B; PYGMA; SOCS3B; CALML5
Melanogenesis
TYRP1B; CALM; TCF7L2; GSK3B; PRKCA; FZD8A; PLCB1; CALM3A; EP300; FZD7
Prolactin signaling pathway
FOS; SOCS5; INS; MAPK8; PIK3CG; SOCS2; KRAS; STAT5B; CCND1; PIK3R2
Thyroid hormone signaling pathway
MED12; HDAC3; DIO1; PRKACG; ITGB3; PIK3CD; HDAC2; CASP9; MED1; MTOR
Insulin resistance
SLC27A1A; SLC27A3; PIK3R3A; PRKCZ; PRKAG2A; GYS1; PIK3R5; SLC27A1B; PRKAG1; SLC27A5
Non-alcoholic fatty liver disease (NAFLD)
PPARA; GSK3A; RXRA; MAPK10; UQCRB; BID; NDUFS5; COX7B2; TRAF2; PRKAA1
Alzheimers disease
CALM1; NDUFA4L2; NOS1; NDUFS1; NDUFA8; NAE1; BACE2; COX4I2; NDUFA1; ITPR2
Hepatitis C
CLDN10; STAT1; PPP2R1A; IFNA6; TNFRSF1A; BAD; CLDN17; NFKB1; TYK2; MAPK13
Measles
OAS1A; IFNA2; TNFRSF10A; EIF2AK1; IL2RA; CD3D; PIK3CA; STAT5B; IFNA16; IL6
Influenza A
EIF2AK1; BCL2L2-PABPN1; FDPS; IL1A; IFNAR1; TMPRSS13; MAP2K7; IL12B; NXF1; MAP2K4
HTLV-I infection
TNFRSF13C; FOS; H2-Q10; H2-AA; GSK3B; PPP3R2; NRP1; DLG1; RELA; TP53INP1
Epstein-Barr virus infection
BCL2; HLA-DRB5; SND1; TRAF6; POLR3K; HLA-C; RAN; TNFAIP3; POLR2E; TAB2
Pathways in cancer
AHA-1; FGF7; PLD1; LAMA4; PTGER4; GNB1; PLCB2; CXCL12; LEF1; FZD3
Colorectal cancer
TGFB1; TCF7L2; RAF1; LEF1; APPL1; TP53; MAPK9; MAPK10; RHOA; CCND1
Endometrial cancer
CDH1; CASP9; BAD; CTNNA3; HRAS; SOS1; PIK3CB; PTEN; GSK3B; MAP2K2
Prostate cancer
SRD5A2; SMARCA4; ACTL6B; HSP90AB1; TCF7; TRP53; PIK3R5; KRAS; CCNE2; PIK3R2
Basal cell carcinoma
DVL1; FZD8; FZD3; GLI2; HHIP; WNT3A; WNT6; WNT7A; WNT7B; WNT16

Protein Function

GSK3B has several biochemical functions, for example, ATP binding, NF-kappaB binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PAK2A; PRKG1; KIF20A; NWD1; MARK4; ABCB1A; OBSCN; RIOK1; ROR2; ACSL1
Function NF-kappaB binding
Related Protein RNF25; HDAC1; HIF1AN; ANKRD42; CDKN2A; RELA; HDAC3; TAF4B; NPM1; GSK3B
Function RNA polymerase II transcription factor binding
Related Protein XBP1; NFATC1; GSC; KDM1A; SPOP; TBX6; ID4; GATA5; TBX20; TP53
Function beta-catenin binding
Related Protein TCF7L2; BCL9; CD2AP; APC2; CTNNBIP1; GSK3B; LZTS2A; LEF1; LZIC; GLI3
Function kinase activity
Related Protein PKMYT1; SMOK2B; ACVR1L; ACVR1BA; STK30; CDKN1D; CDK12; PHKG1B; EPHA4A; PRKCDA
Function p53 binding
Related Protein ZFP385C; SETD8; ZMAT4; PLK3; RCHY1; KDM1A; TAF1; USP10; ZNF385D; TP73
Function protein binding
Related Protein ADAMTS4; SMAP2; PAX5; GLTP; NSMAF; DYRK1A; DNAJC5B; APPB; FBXW9; BIRC2
Function protein kinase A catalytic subunit binding
Related Protein GSK3A; EZR; PRKAR1A; KCNQ1; SOX9; PRKAR2B; CSK; RYR2; PRKAR2A; PJA2
Function protein kinase binding
Related Protein CHRNA7; GRB7; AURKA; SPDYB; MEF2A; TBL2; FAM83A; ILK; PTPN23; HSPB1
Function protein serine/threonine kinase activity
Related Protein RAF1B; PRPF4B; ROCK2B; TSSK2; ZAK; MASTL; LMTK3; BMPR1A; PHKG2; GRK7B
Function tau-protein kinase activity
Related Protein PHKG1; PRKAA1; GSK3A; CSNK1D; PHKG2; GSK3B; CDK5; MARK1; MARK2; MARK4
Function ubiquitin protein ligase binding
Related Protein PINK1; CDKN1A; HERC2; WFS1; PDE4D; HSPA8; RRAGA; TSG101; MAGEC2; TRIM37

Interacting Protein

GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.
AXIN1

GSK3B Related Articles

Solich, J; Kolasa, M; et al. Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study. PHARMACOLOGICAL REPORTS 67:345-348(2015).
Yuan, YH; Yan, WF; et al. The molecular mechanism of rotenone-induced alpha-synuclein aggregation: Emphasizing the role of the calcium/GSK3 beta pathway. TOXICOLOGY LETTERS 233:163-171(2015).