gsk3b
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  • Official Full Name
  • glycogen synthase kinase 3 beta
  • Background
  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
  • Synonyms
  • GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
Cat.#:GSK3B-2129HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GSK3B Protein (1-420 aa), His-tagged
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Cat.#:GSK3B-2350HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GSK3B Protein, MYC/DDK-tagged
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Cat.#:GSK3B-4399HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSK3B Protein, GST-tagged
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Cat.#:GSK3B-1886HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-120HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B Protein, DDK-tagged
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Cat.#:GSK3B-28628THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-28630THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-326HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B protein, GST-tagged
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Cat.#:GSK3B-376HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human GSK3B Protein, His-tagged
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Cat.#:GSK3B-406HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human glycogen synthase kinase 3 beta, His-tagged
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Cat.#:GSK3B-616HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B, His tagged
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Cat.#:GSK3B-735HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:Gsk3b-2521MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Gsk3b, His tagged
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Cat.#:GSK3B-2728RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GSK3B Protein
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Cat.#:GSK3B-8957ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GSK3B
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Cat.#:GSK3B-2649HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1022HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-1540HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3 beta, Unactive, GST-tagged
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Cat.#:GSK3B-2857HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (C-79aa), His-tagged
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Cat.#:GSK3B-2858HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (1-351aa), His-tagged
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Cat.#:GSK3B-717HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B cell lysate
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Cat.#:GSK3B-534MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse GSK3B cell lysate
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Involved Pathway

GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
TGFA; PAK2B; MAP2K2B; HRAS; PIK3CG; AKT2L; PIK3CB; MAPK10; NCK2A; NCK2B
Chemokine signaling pathway
PPBP; CCL28; PARD3; RAC1; GNB3; PTK2B; XCL1; WASL; Ccl12; RHOA
Cell cycle
SKA1; MYBL2; PTTG1; CDKN2C; GADD45B; CENPK; SYCE1; ESCO1; CENPA; RB1
PIK-Akt signaling pathway
IRS1; PPP2R5B; NGF; TLR4; KRAS; PDGFRB; COL27A1; PGF; PIK3CB; PDPK1
Wnt signaling pathway
SENP2; PRICKLE2B; RHOAD; RAC1B; WNT11R; FZD3B; PORCN; PRKACBA; NFATC4; CSNK1A1L
Hedgehog signaling pathway
DYRK1AA; LRP2; CSNK1DA; WNT3; WNT8A; BTRC; PRKACB; WNT5A; GSK3AA; GSK3B
Axon guidance
ARHGEF12; LAMTOR2; RHOA; Sema3f; ARHGEF28; PPP3R2; SCN2B; JAK1; CFL2; CAP2
Hippo signaling pathway
SERPINE1; BIRC5; GDF7; WNT6; YWHAE; LIMD1; TCF7L2; PPP2CA; SMAD4; LEF1
Focal adhesion
PIK3R2; TNXB; PRKCG; RAC1B; LAMA3; ITGA9; PDGFC; BRAF; AKT2; Itga10&Itgb1
Signaling pathways regulating pluripotency of stem cells
AKT2; SMAD1; FGFR3; INHBA; FZD5; RAF1; MYF5; ACVR1B; LEFTY2; SKIL
T cell receptor signaling pathway
SOS1; PIK3CB; CD28; PIK3R2; MAPK13; MAP2K7; CD3G; PIK3CG; IKBKB; ZAP70
B cell receptor signaling pathway
HRAS; CD79A; RASGRP3; MAPK1; LAT2; DUSP6; CDK6; PILRB; ACTR3; CDK7
Neurotrophin signaling pathway
NTRK1; ARHGDIG; SHC3; KRAS; RAPGEF1; BDNF; MAPK1; IKBKB; SOS1; NTF3
Dopaminergic synapse
GNAS; PRKCA; MAOA; GRIA4; CALY; KIF5C; SLC6A3; CALML3; KCNJ3; GNAQ
Insulin signaling pathway
CBLC; MKNK2; BAD; SH2B2; CALML3; RAPGEF1; CALML5; INS; MKNK1; MAPK8B
Melanogenesis
PRKACA; MAP2K2A; WNT4A; ADCY2B; GNAO1B; RAF1A; CAMK2D1; TCF7; CALM2; FZD3B
Prolactin signaling pathway
CSN2; PRP2; AKT1; STAT1; NRAS; ESR1; INS2; LHB; SIRPA; STAT5B
Thyroid hormone signaling pathway
TRP53; BMP4; PIK3CB; DIO1; MAP2K2; KAT2A; HDAC2; NOTCH4; SRC; SLC9A1
Insulin resistance
PRKCE; RPS6KA3B; FOXO1B; PPP1CAB; PRKCZ; PPP1R3DA; MAPK10; NOS3; INSRA; PIK3R3B
Non-alcoholic fatty liver disease (NAFLD)
IL1A; INS2; ITCH; Il6ra; ADIPOR1; UQCR10; NDUFV1; NDUFB9; FASLG; Casp3
Alzheimers disease
PSEN1; Casp3; COX8A; ATP5O; CALML3; CAPN1; GNAQ; ATP2A3; GRIN2D; CHP
Hepatitis C
IKBKG; IRF9; CLDN14; CLDN10; CLDN16; EIF2AK4; CD81; IFNAR2; OSTN; RELA
Measles
IRF7; RELA; EIF2AK3; IRAK4; MAVS; IFNA16; IRF3; IFNA4; TLR9; STAT5B
Influenza A
PABPN1L; Ccl12; HLA-DRB3; RAF1; DNAJB1; Ifna15; MX1; PRKCA; HLA-DOA; BMA2
HTLV-I infection
PPP3CC; POLB; EP300; MYB; RANBP1; FZD3; CRTC2; FZD2; PRKACA; IKBKG
Epstein-Barr virus infection
PRKACA; RBPJL; PLCG1; SYK; PIK3CD; HSPA1A; HLA-DRB1; SND1; HLA-G; YWHAE
Pathways in cancer
LAMA3; PTEN; RAC3; HDAC1; NFKB1; PDGFA; CTBP2; TGFB2; CUL2; MAPK10
Colorectal cancer
RAF1; SMAD4; CASP9; MAPK1; LEF1; TCF7L2; SMAD3; RAC1; MAPK3; MLH1
Endometrial cancer
RAF1; GRB2; FOXO3; AXIN1; HRAS; PDPK1; TP53; NRAS; PIK3R2; AXIN2
Prostate cancer
SMARCA4; HRAS; FOXA1; Ar; TCF7; NFKBIA; KRAS; MAPK1; PIK3CG; ARAF
Basal cell carcinoma
FZD8; PTCH1; APC2; WNT3A; WNT6; Fzd4; SETD6; WNT9A; WNT2B; TRP53

Protein Function

GSK3B has several biochemical functions, for example, ATP binding, NF-kappaB binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PKLR; PRPS1L1; TRPM4; OPLAH; XYLB; ATP2A1; MAPK3; Abca2; PKN1B; MKKS
Function NF-kappaB binding
Related Protein FAF1; CDKN2A; BCL10; HIF1AN; HDAC1; ANKRD42; COMMD6; DNAJA3; RELA; ANXA4
Function RNA polymerase II transcription factor binding
Related Protein GSK3B; CREBBP; KDM1A; MKX; GATA1A; ZFPM2; TBX3; ATF4; ZFPM2A; XBP1
Function beta-catenin binding
Related Protein CHD8; SALL1; CALCOCO1; CDH24; BCL9L; HDAC6; PXN; TAX1BP3; Ar; MED12
Function kinase activity
Related Protein PKM2; MAPK12B; IGF1RA; WNK2; PHKG1A; FGFR1A; DCLK1A; CDK5; PFKFB4L; BSK146
Function p53 binding
Related Protein EP300; SMYD2; RCHY1; HTT; RFFL; NTRK3; SMARCA4; TP53RK; GSK3B; TP63
Function protein binding
Related Protein LEMD3; NFATC3; PROCR; pab1; GTSE1; MYO10; ERCC6L; HDAC7A; KRT80; H2AFZ
Function protein kinase A catalytic subunit binding
Related Protein PRKAR2B; EZR; GSK3A; PRKAR1A; CSK; RYR2; SOX9; PRKAR1B; PRKAR2A; KCNQ1
Function protein kinase binding
Related Protein TSACC; PTK2; SQSTM1; MAP3K1; EMP2; SPDYA; TRP53; BORA; SNAP91; TPRKB
Function protein serine/threonine kinase activity
Related Protein RPS6KA5; AAK1; ERN2; PIM1; NIM1K; SLC14A2; MAP3K9; TTBK2; PRKAA2; CAMK1GB
Function tau-protein kinase activity
Related Protein MARK2; MARK1; MARK4; PHKG1; GSK3A; CSNK1D; PRKAA1; PHKG2; CDK5; GSK3B
Function ubiquitin protein ligase binding
Related Protein PER3; EGFR; STX8; NFKBIA; CD40; SUMO1; UBXN6; PRR5L; PIAS1; AURKA

Interacting Protein

GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.
AXIN1

GSK3B Related Articles

Solich, J; Kolasa, M; et al. Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study. PHARMACOLOGICAL REPORTS 67:345-348(2015).
Yuan, YH; Yan, WF; et al. The molecular mechanism of rotenone-induced alpha-synuclein aggregation: Emphasizing the role of the calcium/GSK3 beta pathway. TOXICOLOGY LETTERS 233:163-171(2015).