gsk3b
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  • Official Full Name
  • glycogen synthase kinase 3 beta
  • Background
  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
  • Synonyms
  • GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
Cat.#:GSK3B-2129HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GSK3B Protein (1-420 aa), His-tagged
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Cat.#:GSK3B-2350HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GSK3B Protein, MYC/DDK-tagged
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Cat.#:GSK3B-4399HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSK3B Protein, GST-tagged
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Cat.#:GSK3B-1886HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-120HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B Protein, DDK-tagged
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Cat.#:GSK3B-28628THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-28630THTag:
Source (Host):Species:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-326HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B protein, GST-tagged
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Cat.#:GSK3B-376HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human GSK3B Protein, His-tagged
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Cat.#:GSK3B-406HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human glycogen synthase kinase 3 beta, His-tagged
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Cat.#:GSK3B-616HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B, His tagged
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Cat.#:GSK3B-735HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:Gsk3b-2521MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Gsk3b, His tagged
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Cat.#:GSK3B-2728RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GSK3B Protein
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Cat.#:GSK3B-8957ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GSK3B
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Cat.#:GSK3B-2649HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1022HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-1540HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3 beta, Unactive, GST-tagged
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Cat.#:GSK3B-2857HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (C-79aa), His-tagged
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Cat.#:GSK3B-2858HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (1-351aa), His-tagged
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Cat.#:GSK3B-717HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B cell lysate
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Cat.#:GSK3B-534MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse GSK3B cell lysate
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Involved Pathway

GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
NCK2A; CBL; SHC1; PTK2; CDKN1BB; ELK1; HRASB; SOS1; PIK3R3A; BTC
Chemokine signaling pathway
CXCL11; CCL19; CCL22; NRAS; Cxcl15; CCL24; WASL; PREX1; GM13304; LYN
Cell cycle
CDK4; MIS18A; PHF8; CHEK1; SMC4; NUPL2; CSNK2A1; CDKN2B; CDKN1C; FZR1A
PIK-Akt signaling pathway
PRLR; ITGA9; RAC1; IL6; FGF18; Gh; LAMA2; RXRA; GRB2; INS1
Wnt signaling pathway
NKD1; NKD2; PRKCG; SFRP4; RAC1B; LRP5; PLCB2; CTBP2A; WNT11R; PORCN
Hedgehog signaling pathway
RAB23; WNT11R; ZIC2A; PTCH1; Shh; STK36; WNT2BA; WNT2; CSNK1G2; WNT5B
Axon guidance
ABLIM3; KIF4; KBTBD7; HFE2; RNF8; SCN3A; CLTB; RAC3; AKAP9; PLXNC1
Hippo signaling pathway
LLGL2; TGFBR1; YWHAZ; SMAD2; BMP4; BTRC; WWC1; PPP2R1B; BBC3; JUB
Focal adhesion
IBSP; GRB2; FLNB; IGF1; DIAP1; PAK7; VEGFB; SRMS; THBS3; ITGA2
Signaling pathways regulating pluripotency of stem cells
SMARCAD1; FZD1; FGF2; HOXB1; WNT2; FGFR3; NODAL; MAPK12; WNT9A; OTX1
T cell receptor signaling pathway
CD40LG; PAK6; NFKBIE; SLA1; MAPK3; PIK3CA; CBLB; SOS1; PLCG1; TNF
B cell receptor signaling pathway
ARPC2; DOK1B; ARPC1B; PDK2; BCL2L11; PTPN18; ITPR2; PRKCB; CDK2; ACTR3
Neurotrophin signaling pathway
RIPK2; CAMK4; NTF3; SHC2; MAPK9; MAPK12; PIK3CG; PIK3R2; PSEN2; BAD
Dopaminergic synapse
CAMK2B; KIF5A; CREB5; GRIA3; PPP2CA; GSK3A; CREB3L4; SLC18A1; GNGT2; CREB3L2
Insulin signaling pathway
FLOT2B; PCK2; FOXO1B; RAF1; GRB2; GSK3AA; TRIP10A; AKT3A; PCK1; SHC2
Melanogenesis
HRAS; GNA11A; WNT3A; MAP2K2; WNT2BB; PLCB3; MAP2K2B; CALM2A; WNT8B; FZD8
Prolactin signaling pathway
PPIB; PIK3R1; SHC3; MAP2K1; STAT1; PIK3CG; SOCS4; CCND1; AKT1; MAPK13
Thyroid hormone signaling pathway
ATP2A2; PLCB3; FOXO1; NCOA1; MAP2K2; PFKP; DIO2; PLN; PRKCB; MED30
Insulin resistance
PPARAB; PRKAG3B; PTPRF; SLC27A1A; TNFRSF1A; PRKCQ; PYGM; SOCS3; PPP1R3A; GYS1
Non-alcoholic fatty liver disease (NAFLD)
NDUFA4L2; LEP; MAPK8; RAC1; NDUFA6; NDUFS1; ADIPOR1; NDUFV3; PRKAG1; PIK3R1
Alzheimers disease
NDUFA3; RYR3; COX4I2; COX6A1; NDUFA4L2; NAE1; GRIN2B; ATP2A1; CDK5; NDUFS6
Hepatitis C
IFIT1; IKBKB; TLR3; TRAF2; EIF2AK2; CLDN15; TYK2; CLDN9; SCARB1; PIAS1
Measles
IFNA4; OAS2; MX1; STAT3; OAS1A; IFNA10; HSPA2; CLEC4M; CD28; IL12B
Influenza A
HLA-DQA2; HLA-DOB; IFNA17; MAPK12; IFNAR1; IFNA16; IRF9; IFNA4; MAP2K6; IFIH1
HTLV-I infection
CANX; GSK3B; WNT8A; MAP2K4; HLA-E; NFATC3; IL2RA; Fzd4; CDC20; WNT6
Epstein-Barr virus infection
EP300; PSMD1; TAB1; HLA-DRB5; PSMD8; CCNA1; HDAC5; HLA-B; RIPK1; POLR3B
Pathways in cancer
GNG8; RUNX1T1; RHOA; COL4A1; MAP2K2; STAT5A; FGF16; GLI2; NFKB1; SOS1
Colorectal cancer
AXIN1; TGFB2; BCL2; MAP2K1; ARAF; MSH3; Casp3; APC2; BIRC5; TCF7L2
Endometrial cancer
ILK; RAF1; LEF1; ELK1; CCND1; FOXO3; AXIN1; PIK3R3; MAP2K2; BRAF
Prostate cancer
PDPK1; IKBKB; NKX3-1; TCF7; ARAF; PDGFRB; RB1; TP53; SPRY1; INS1
Basal cell carcinoma
BMP4; STK36; SUFU; FZD1; WNT3A; GLI2; WNT16; WNT1; TCF7L2; FZD8

Protein Function

GSK3B has several biochemical functions, for example, ATP binding, NF-kappaB binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein Aatk; BMP2K; SWAP70; RIPK2; CHD1L; NUAK2; PRPS2; CKMA; HSPA4A; DDX4
Function NF-kappaB binding
Related Protein COMMD7; NFKBID; ANKRD42; HDAC3; DNAJA3; EP300; SNAI1A; CDK5RAP3; RNF25; BCL10
Function RNA polymerase II transcription factor binding
Related Protein TRPS1; GATA5; ZFPM1; CREBBP; SMAD4; CHST13; GATA6; PITX2; NFATC1; ANKRD1
Function beta-catenin binding
Related Protein KLF4; CARM1; CTNNBIP1; CDH2; TCF7; SLC9A3R1; LZTS2A; AXIN2; SOX9; GSK3B
Function kinase activity
Related Protein LTK; PPM1E; BMPR2B; EPHB3A; MIBP; Fert2; DCKL1B; PRKAR2AB; BCR; CKMT2B
Function p53 binding
Related Protein GATA1; ZNF385C; GSK3B; ZMAT4; BCL2L12; NTRK3; CHD8; MAPKAPK5; TRIM29; STK11
Function protein binding
Related Protein CD46; TRIM43; FGF13; PPP1R2P9; EXOSC8; GDNF; HDGFRP2; ENTPD3; ZMYM4; DLC1
Function protein kinase A catalytic subunit binding
Related Protein CSK; SOX9; GSK3A; PJA2; KCNQ1; PKIA; PRKAR1B; RYR2; GSK3B; PRKAR2B
Function protein kinase binding
Related Protein TRAP1; CAMK2N2; PRKAB1; GRIN2A; PARK2; NBEA; SPAG16; STX1B; PAK2; RNF138
Function protein serine/threonine kinase activity
Related Protein TAOK1; CAMK2D1; MAP4K2; OXSR1A; PINK1; ALPK1; CAMK2D2; PBK; STK24; CSNK2A2
Function tau-protein kinase activity
Related Protein MARK1; GSK3B; MARK2; MARK4; CDK5; PHKG2; GSK3A; PRKAA1; CSNK1D; PHKG1
Function ubiquitin protein ligase binding
Related Protein FHIT; UBE2B; FZD5; CALR; PRKAR1A; OTUB1; CASC3; GABARAPL1; RNF40; MID1

Interacting Protein

GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.
AXIN1

GSK3B Related Articles

Solich, J; Kolasa, M; et al. Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study. PHARMACOLOGICAL REPORTS 67:345-348(2015).
Yuan, YH; Yan, WF; et al. The molecular mechanism of rotenone-induced alpha-synuclein aggregation: Emphasizing the role of the calcium/GSK3 beta pathway. TOXICOLOGY LETTERS 233:163-171(2015).