| Official Full Name | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
| Background | The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75 and GRP78. GRP78 is localized in the endoplasmic reticulum where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains. |
| Synonyms | HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); GRP78, heat shock 70kD protein 5 (glucose regulated protein, 78kD); 78 kDa glucose-regulated protein; BiP; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; MIF2; GRP78; FLJ26106 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
HSPA5 involved in several pathways and played different roles in them. We selected most pathways HSPA5 participated on our site, such as Protein export, Protein processing in endoplasmic reticulum, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein export | SPCS3; SEC62; SRP9; SEC61AL2; SRP68; SEC63; SRP19; SRP54; SLC38A8; OXA1L |
| Protein processing in endoplasmic reticulum | DNAJB12; RRBP1; SVIP; TUSC3; DNAJC5G; RBX1; UBE2E1; SAR1B; SSR2; SSR4 |
| Antigen processing and presentation | HLA-DQB1; H2-Q10; KLRD1; HLA-DOA; HSPA5; TAPBP; CTSS; HLA-G; HLA-DRB3; NFYB |
| Thyroid hormone synthesis | PRKACA; SLC5A5; ASGR2; CREB3L3; PLCB4; Adcy4; ATP1B3; PRKCB; PLCB2; DUOXA2 |
| Prion diseases | IL1B; C1QA; HSPA1A; C7; STIP1; C1QC; C6; ELK1; IL6; PRNP |
HSPA5 has several biochemical functions, for example, ATP binding, ATPase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA5 itself. We selected most functions HSPA5 had, and list some proteins which have the same functions with HSPA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CKBB; NRBP2; CDC7; CLPXA; CDK1; MYH1E; TNNI3K; PIK3C2G; HELZ2; MAPK12A |
| ATPase activity | ATAD2B; PSMC1; ATF7IP; KIF7; KIF13B; MYH8; EIF4A1B; EIF4A2; ABCG2D; ABCA4 |
| calcium ion binding | EGFL8; PPEF2; SLC25A23; CALML4A; MAN1C1; CUBN; CDH12A; NUCB2; PNLIPRP1; PCDHB16 |
| chaperone binding | RNF207; TBCE; H2-KE2; CXorf41; SERPINA7; BAG4; DNAJA2; HSPD1; DNAJA3A; BAG2 |
| enzyme binding | ARRB2; ATP2A2; BCL10; PHKG2; KDM4C; SCN5A; TMBIM6; HIST1H2AE; KALRN; MDM2 |
| glycoprotein binding | F7; CDH1; ITGAM; TGFB1; VWF; FGFR1; EDEM2; BMPR1A; VLDLR; CANX |
| misfolded protein binding | CLU; EDEM1; STUB1; HDAC6; HSPD1; TOR1A; HSPA5; F12; DNAJB9; BAG6 |
| protein binding | CRADD; DCTN1; ADAMTS4; SAE1; PCID2; SP2; PPP1R15B; LGALS2; TMEM242; TNFSF13B |
| protein domain specific binding | TJP1; MRPL17; GABRR2; GABRR1; ATP1A1; ACSL3; HIST1H4F; CHMP1B; DBNL; ESRRA |
| ribosome binding | ETF1; ETF1B; OLA1; C12orf65; RPSA; CPEB3; RPN2; EIF6; MTOR; SBDS |
| ubiquitin protein ligase binding | WASH; TMEM189; SMAD6; EGFR; SMAD3; TCEB2; AKTIP; TRP53; MAGEA2B; JAK1 |
| unfolded protein binding | CCT6B; HSP26; DNAJB1; DNAJA4; CCT2; CANX; PFDN1; TUBB4B; HSPE1; DNAJA3A |
HSPA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA5.
DNAJB11; DMKN; RAF1; Pawr; PAWR
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