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HSPA5

  • Official Full Name

    heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

  • Overview

    The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75 and GRP78. GRP78 is localized in the endoplasmic reticulum where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains.
  • Synonyms

    HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); GRP78, heat shock 70kD protein 5 (glucose regulated protein, 78kD); 78 kDa glucose-regulated protein; BiP; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; MIF2; GRP78; FLJ26106;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus Monkey
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPA5-1551H Active Recombinant Human HSPA5 protein, His-tagged E.coli His
Human HSPA5-4710H Recombinant Human Heat Shock 70kDa Protein 5 (glucose-regulated protein, 78kDa), His-tagged Human His
Human HSPA5-5107H Recombinant Human HSPA5 Protein, GST-tagged Wheat Germ GST
Human HSPA5-1550H Active Recombinant Human GRP78 Protein, His-tagged E.coli His 2-654
Human HSPA5-3677H Recombinant Human, HSPA5 His-tagged E.coli His
Human HSPA5-27412TH Recombinant Human HSPA5, His-tagged E.coli His
Human HSPA5-3349H Recombinant Human HSPA5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSPA5-1119H-B Recombinant Human HSPA5 Protein Pre-coupled Magnetic Beads HEK293
Human HSPA5-570H Recombinant Human HSPA5 Protein, His-tagged E. coli His
Human HSPA5-5108H Recombinant Human HSPA5 protein, GST-tagged E.coli GST
Human HSPA5-068H Active Recombinant Human HSPA5 Protein, His-tagged E. coli His 2-654
Human HSPA5-014H Active Recombinant Human HSPA5 Protein, His-tagged E.coli His 2-654
Human HSPA5-968H Recombinant Human HSPA5 Protein, GST-tagged E.coli N-GST Glu19-Leu654
Human HSPA5-12H Recombinant Human HSPA5 Protein (Glu19-Leu654), C-His-tagged HEK293T C-His Glu19-Leu654
Human HSPA5-3897HF Recombinant Full Length Human HSPA5 Protein, GST-tagged In Vitro Cell Free System GST 19-654 amino acids
Human HSPA5-8942H Recombinant Human HSPA5 Protein, His-tagged E. coli His 20-650
Human HSPA5-52HFL Active Recombinant Full Length Human HSPA5 Protein, C-Flag-tagged Mammalian cells Flag
Human HSPA5-3361H Recombinant Human HSPA5 Protein (Met1-Leu654), N-His tagged E.coli N-His Met1-Leu654
Human HSPA5-1119H Recombinant Human HSPA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSPA5-8943H Recombinant Human HSPA5 Protein, His-tagged E. coli His 19-654
Human HspA5-049H Recombinant Human HspA5 Protein, C-His-tagged E.coli C-His 654
Human HSPA5-2197H Recombinant Human HSPA5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HSPA5-3058H Recombinant Human HSPA5 protein, His-tagged E.coli His 25-293aa
Human HSPA5-3360H Recombinant Human HSPA5 Protein (Leu351-Leu654), N-His tagged E.coli N-His Leu351-Leu654
Mouse Hspa5-2071M Recombinant Mouse Heat Shock Protein 5 E.coli N/A
Mouse Hspa5-238M Recombinant Mouse Hspa5 Protein, His-tagged E.coli His 20-655aa
Mouse HSPA5-3232M Recombinant Mouse HSPA5 protein, His-GST-tagged E.coli His/GST Glu20~Leu655
Mouse Hspa5-571M Recombinant Mouse Hspa5 Protein, His-tagged E.coli His Gln261~Glu470
Mouse Hspa5-1067M Recombinant Mouse Hspa5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HSPA5-2010M Recombinant Mouse HSPA5 Protein (20-655 aa), His-tagged Yeast His 20-655 aa
Mouse Hspa5-969M Recombinant Mouse Hspa5 Protein, His-tagged HEK293F N-His Met+Glu20-Leu655
Mouse Hspa5-970M Recombinant Mouse Hspa5 Protein, GST-tagged E.coli N-GST Glu20-Leu655
Rat Hspa5-1552R Active Recombinant Rat Hspa5 protein, His-tagged E.coli His
Rat HSPA5-2948R Recombinant Rat HSPA5 Protein Mammalian Cell His
Rat HSPA5-2603R-B Recombinant Rat HSPA5 Protein Pre-coupled Magnetic Beads HEK293
Rat Hspa5-1639R Recombinant Rat Hspa5 Protein, His-tagged E.coli N-His Gln260-Glu469
Rat HSPA5-2603R Recombinant Rat HSPA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Monkey HSPA5-2165RF Recombinant Full Length Rhesus Monkey HSPA5 Protein, C-His tagged HEK293 C-His
Rhesus Macaque HSPA5-2165R Recombinant Rhesus monkey HSPA5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HSPA5-1986R Recombinant Rhesus Macaque HSPA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HSPA5-1986R-B Recombinant Rhesus Macaque HSPA5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HSPA5-12291Z Recombinant Zebrafish HSPA5 Mammalian Cell His
Chicken HSPA5-7040C Recombinant Chicken HSPA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPA5 Related Articles

HSPA5 involved in several pathways and played different roles in them. We selected most pathways HSPA5 participated on our site, such as Protein export, Protein processing in endoplasmic reticulum, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein exportSRPRB;SEC61AL2;SPCS3;SRP54B;SRP14;SPCS1;ARXES1;SEC61G;SRP68
Protein processing in endoplasmic reticulumHSPA1B;UBQLN4;UBE2D2L;DNAJB1B;SVIP;CAPN2;ATF4;HSPA5;DNAJB1
Antigen processing and presentationKIR2DL3;CD74;HLA-DOA;RFXANK;HLA-DMB;HSPA2;HLA-C;CD8A;NFYC
Thyroid hormone synthesisHSPA5;ATP1A1;DUOXA2;ATP1A3;GPX2;CREB3L1;TSHB;PRKACB;TTF2
Prion diseasesCCL5;PRKACB;LAMC1;MAP2K1;HSPA1A;IL1B;ELK1;PRKACG;C8B

HSPA5 has several biochemical functions, for example, ATP binding, ATPase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA5 itself. We selected most functions HSPA5 had, and list some proteins which have the same functions with HSPA5. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNUAK2;TBK1;SCYL1;CDC42BPG;ABCF2;GKUP;CCT6A;STK10;SPG7
ATPase activityABCC5;DNAH6;MYH7;SMARCA5;KIF15;DQX1;OLA1;KIF3CB;WRNIP1
calcium ion bindingADAMTS13;ANXA11A;PCDH15A;CAPN2A;PCDH2AB1;SLC25A23B;PLA2G10;S100U;SYT7
chaperone bindingDNAJC10;DNAJB8;DNAJB1;TIMM44;FGB;HSP104;CDKN1B;USP13;HSPE1
enzyme bindingPTEN;EHHADH;NPM2;GNB2L1;HSPA1A;UGT1A2;CABYR;FAM84B;SRC
glycoprotein bindingCNTN2;LCK;LRRK2;DNAJA2;FGFR1;IGF2R;IDE;Serpina1b;B2M
misfolded protein bindingDNAJB9;DNAJC3;HDAC6;EDEM1;F12;HSPA5;SDF2L1;STUB1;CLU
protein bindingDNAJC28;CDC45;TP53;MAGEA1;MEP1A;IL4R;HERPUD1;RPUSD4;ALKBH6
protein domain specific bindingATP1A1;DBNL;YWHAG1;ARFIP2B;MLF1;RUNX2;PRKCI;SHC4;ICA1L
ribosome bindingETF1A;CPEB2;MTRF1L;MTRF1;ABCF1;ETF1;EIF2S1B;BAG6;HSPA5
ubiquitin protein ligase bindingIKBKG;PER3;RAD18;CUL4A;WASH;TRIB1;CUL4B;GPI1;TP53
unfolded protein bindingCCT5;SSUH2.2;DNAJA2L;HSP90AA1.2;DNAJB6;HSPA9;HTRA2;DNAJB4;HSPA1L

HSPA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA5.

DNAJB11; DMKN; RAF1; Pawr; PAWR

Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
Maetzler, W; Apel, A; et al. Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson's Disease Patients and Controls. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there drugs targeting HSPA5 currently in development? 03/16/2021

Some studies explore small molecules and compounds that target HSPA5 as potential therapeutic agents, but clinical applications are still under investigation.

In what other medical conditions is HSPA5 relevant? 01/27/2021

HSPA5 is involved in various conditions, including cardiovascular diseases, diabetes, and neurodegenerative disorders.

Are there diagnostic applications of HSPA5 in cancer? 03/16/2018

Elevated levels of HSPA5 in certain cancers may serve as a diagnostic marker, providing information about the cellular stress response and potential malignancy.

Is there a relationship between HSPA5 and autoimmune disorders? 11/19/2017

HSPA5's involvement in the immune response suggests potential links to autoimmune disorders, but specific mechanisms are still being studied.

How does HSPA5 influence the immune response? 03/25/2016

HSPA5 is involved in antigen presentation, linking its role in protein folding to the modulation of immune responses.

Customer Reviews (3)

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Reviews
07/02/2022

    This level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.

    01/18/2020

      Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.

      07/07/2019

        researchers highly appreciate HSPA5 protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.

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