HSPA5 Protein, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

HSPA5

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HSPA5

Official Full Name heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Background The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75 and GRP78. GRP78 is localized in the endoplasmic reticulum where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains.
Synonyms HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); GRP78, heat shock 70kD protein 5 (glucose regulated protein, 78kD); 78 kDa glucose-regulated protein; BiP; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; MIF2; GRP78; FLJ26106
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSPA5-1550H Recombinant Human GRP78 Protein, His-tagged E.coli His
    Human HSPA5-014H Recombinant Human HSPA5 Protein, His-tagged E.coli His
    Mouse Hspa5-1067M Recombinant Mouse Hspa5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse HSPA5-2010M Recombinant Mouse HSPA5 Protein (20-655 aa), His-tagged Yeast His
    Human HSPA5-5108H Recombinant Human HSPA5 protein, GST-tagged E.coli GST
    Human HSPA5-1551H Recombinant Human HSPA5 protein, His-tagged E.coli His
    Human HSPA5-2197H Recombinant Human HSPA5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HSPA5-27412TH Recombinant Human HSPA5, His-tagged E.coli His
    Human HSPA5-3677H Recombinant Human, HSPA5 His-tagged E.coli His
    Human HSPA5-4710H Recombinant Human Heat Shock 70kDa Protein 5 (glucose-regulated protein, 78kDa), His-tagged Human His
    Human HSPA5-5107H Recombinant Human HSPA5 Protein, GST-tagged Wheat Germ GST
    Human HSPA5-570H Recombinant Human HSPA5 Protein, His-tagged E. coli His
    Mouse Hspa5-2071M Recombinant Mouse Heat Shock Protein 5 E.coli N/A
    Mouse Hspa5-238M Recombinant Mouse Hspa5 Protein, His-tagged E.coli His
    Mouse Hspa5-571M Recombinant Mouse Hspa5 Protein, His-tagged E.coli His
    Rat Hspa5-1552R Recombinant Rat Hspa5 protein, His-tagged E.coli His
    Rat HSPA5-2948R Recombinant Rat HSPA5 Protein Mammalian Cell His
    Rhesus Macaque HSPA5-2165R Recombinant Rhesus monkey HSPA5 Protein, His-tagged Mammalian Cell His
    Chicken HSPA5-7040C Recombinant Chicken HSPA5 Mammalian Cell His
    Zebrafish HSPA5-12291Z Recombinant Zebrafish HSPA5 Mammalian Cell His

    HSPA5 involved in several pathways and played different roles in them. We selected most pathways HSPA5 participated on our site, such as Protein export, Protein processing in endoplasmic reticulum, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein export SPCS3; SEC62; SRP9; SEC61AL2; SRP68; SEC63; SRP19; SRP54; SLC38A8; OXA1L
    Protein processing in endoplasmic reticulum DNAJB12; RRBP1; SVIP; TUSC3; DNAJC5G; RBX1; UBE2E1; SAR1B; SSR2; SSR4
    Antigen processing and presentation HLA-DQB1; H2-Q10; KLRD1; HLA-DOA; HSPA5; TAPBP; CTSS; HLA-G; HLA-DRB3; NFYB
    Thyroid hormone synthesis PRKACA; SLC5A5; ASGR2; CREB3L3; PLCB4; Adcy4; ATP1B3; PRKCB; PLCB2; DUOXA2
    Prion diseases IL1B; C1QA; HSPA1A; C7; STIP1; C1QC; C6; ELK1; IL6; PRNP

    HSPA5 has several biochemical functions, for example, ATP binding, ATPase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA5 itself. We selected most functions HSPA5 had, and list some proteins which have the same functions with HSPA5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CKBB; NRBP2; CDC7; CLPXA; CDK1; MYH1E; TNNI3K; PIK3C2G; HELZ2; MAPK12A
    ATPase activity ATAD2B; PSMC1; ATF7IP; KIF7; KIF13B; MYH8; EIF4A1B; EIF4A2; ABCG2D; ABCA4
    calcium ion binding EGFL8; PPEF2; SLC25A23; CALML4A; MAN1C1; CUBN; CDH12A; NUCB2; PNLIPRP1; PCDHB16
    chaperone binding RNF207; TBCE; H2-KE2; CXorf41; SERPINA7; BAG4; DNAJA2; HSPD1; DNAJA3A; BAG2
    enzyme binding ARRB2; ATP2A2; BCL10; PHKG2; KDM4C; SCN5A; TMBIM6; HIST1H2AE; KALRN; MDM2
    glycoprotein binding F7; CDH1; ITGAM; TGFB1; VWF; FGFR1; EDEM2; BMPR1A; VLDLR; CANX
    misfolded protein binding CLU; EDEM1; STUB1; HDAC6; HSPD1; TOR1A; HSPA5; F12; DNAJB9; BAG6
    protein binding CRADD; DCTN1; ADAMTS4; SAE1; PCID2; SP2; PPP1R15B; LGALS2; TMEM242; TNFSF13B
    protein domain specific binding TJP1; MRPL17; GABRR2; GABRR1; ATP1A1; ACSL3; HIST1H4F; CHMP1B; DBNL; ESRRA
    ribosome binding ETF1; ETF1B; OLA1; C12orf65; RPSA; CPEB3; RPN2; EIF6; MTOR; SBDS
    ubiquitin protein ligase binding WASH; TMEM189; SMAD6; EGFR; SMAD3; TCEB2; AKTIP; TRP53; MAGEA2B; JAK1
    unfolded protein binding CCT6B; HSP26; DNAJB1; DNAJA4; CCT2; CANX; PFDN1; TUBB4B; HSPE1; DNAJA3A

    HSPA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA5.

    DNAJB11; DMKN; RAF1; Pawr; PAWR

    Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
    Maetzler, W; Apel, A; et al. Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson's Disease Patients and Controls. PLOS ONE 9:-(2014).

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